1. Biopharmaceutical Research University of Manchester Centre of Excellence in Biopharmaceuticals www.coebp.ls.manchester.ac.uk 2. Centre of Excellence in Biopharmaceuticals…

1. Most T cells against self eliminated by central tolerance; but a few escape. 2. LYMPHOCYTES REGOGNIZING EITHER SELF OR NONSELF MUST LIMIT THEIR RESPONSE! 3. DC Mediated…

1. Phenotyping TILs in situ: Automated Enumeration of Intra- and Extra-Follicular FOXP3+ Regulatory T Cells in Follicular Lymphoma J.R. Mansfield,1 C.M. van der Loos,2 ,…

The Management of Sepsis:  What’s New in 2013  Mitchell M. Levy MD, FCCM Professor of Medicine Chief, Division of Pulmonary, Sleep, and Critical Care…

Slide 1 DISEASES OF IMMUNITY Raymond L. Konger, M.D. Associate Professor [email protected] Robbins Pathologic Basis of Disease, 8th Ed. Chapter 6 Slide 2 OBJECTIVES Review…

Slide 1 Team CDK Daniel Packer Rafael Rodriguez Sahat Yalkabov Slide 2 TCR Signaling Pathway  TCR (T cell receptor)  Molecule found on T Cells  Response for recognizing…

Tolerance, Autoimmunity, Immunodeficiences Tolerance is broadly defined as a state of unresponsiveness to an antigen, be it self or foreign Antigen-specific cell receives…

Slide 1 Review: Cells of the Immune System Leukocytes – White blood cells Myelocytes –macrophage, neutrophil, eosinophil,basophil Leukocytes – B, T and NK cells From…

Scurfy Mouse (outside) X-linked recessive inheritance Lethality at 21-25 days Wasting syndrome Exfoliative dermatitis Small, thickened ears Wild type Scurfy Scurfy Mouse…

* Immunoregulation * Immunoregulation:homostasis Normal anti-infection anti-tumour Abnormal Auto-immune disease Tumour Persisitent infection Allergy * SARS patient healthy…