STRUCTURE OF GENE y Gene a segment of DNA that is expressed to yield a functional protein. y Gene term coined by Johanson ( 1909). y Eukaryotic genes are split genes. INTRONS…

1. By: Khaled El MasryAssistant Lecturer of Human Anatomy & EmbryologyMansoura Faculty of Medicine 2. A gene is the sequence of nucleotides in DNAencoding one polypeptide…

Slide 1Genes of cancer Cancer is a disease of abnormal cells Cancer cells proliferate in an uncontrolled fashion The causes of cancer are quite diverse but the central role…

Slide 1 Slide 2 General pattern of cis-acting control elements that regulate gene expression in yeast and metazoans (a) Genes of multicellular organisms contain both promoter-proximal…

Slide 1 Slide 2 Slide 3 Slide 4 Slide 5 Slide 6 Slide 7 Activators bind to enhancer sites, controlled by hormones or other signals. They increase transcript- ion of the regulated…

Slide 1 Outline Questions from last lecture? P. 40 questions on Pax6 gene Mechanism of Transcription Activation –Transcription Regulatory elements Comparison between yeast…

Slide 1 Protein structure Visualization Molecular Story Slide 2 Review “Central Dogma”: Sequence  Structure  function Sequence based analysis Structure based analysis…

Slide 1 Transcription factor II (TFII) TATA Box (Hogness Box) TATAAA (-25, -35) TFII D ---- TATA binding protein (TBP) Poly II a (hypophosphorylated) ---- TAFs (TATA associated…

Spectroscopy of Biopolymers Protein Function Functions of Proteins Binding The most fundamental of these is binding, which underlies all the other biochemical functions of…

Chapter 11: Transcription Initiation Complex Copyright © Garland Science 2007 Genome expression includes 2 steps Initiation of transcription. Assembly of upstream protein…