Slide 1BME 130 – Genomes Lecture 20 Gene expression and mRNA processing Slide 2 Administrivia Homework 2 grading will be finished today Midterm 2 is Friday Final paper…

Slide 1 RNA processing #1 Making ends of RNA Slide 2 Types of RNA processing A) Cutting and trimming to generate ends: –rRNA, tRNA and mRNA B) Covalent modification: –Add…

Slide 1 Discovery of Alternative Splicing First discovered with an Immunoglobulin heavy chain gene (D. Baltimore et al.) Alternative splicing gives two forms of the protein…

Examples of pathways ... ALTERNATIVE SPLICING Irimia & Blencowe Curr Opin Cell Biol 24:323, 2012 Kim Nucl Acids Res 35: 125, 2006 Types of alternative splicing vary in…

Examples of pathways ... ALTERNATIVE SPLICING Irimia & Blencowe Curr Opin Cell Biol 24:323, 2012 Kim Nucl Acids Res 35: 125, 2006 Types of alternative splicing vary in…

RNA processing #1 Making ends of RNA Types of RNA processing A) Cutting and trimming to generate ends: rRNA, tRNA and mRNA B) Covalent modification: Add a cap and a polyA…

Slide 1 Intrinsically Disordered Proteins: from lack of structure to pleiotropy of functions Lilia Iakoucheva University of California, San Diego 1 OUTLINE Characterization…

COUPLING BETWEEN TRANSCRIPTION AND mRNA PROCESSING Mouse (n = 52) Budding / Fission yeast (n = 26 / 29) Structure of RNA Pol II Patrick Cramer, David A. Bushnell, Roger D.…