Slide 1Macroevolution Mark Mayo Cypress College Last update: 8/27/13 Slide 2 2 Macroevolution * Definition – large-scale patterns, trends and rates of change among families…

Slide 1 Protein secondary structure prediction methods TDVEAAVNSLVNLYLQASYLS “From sequence to structure” Slide 2 What are they? –Sequence-based tools for protein structure…

Slide 1 Database Searching Slide 2 Why search databases? To find out if a new DNA sequence already is deposited in the databanks. To find proteins homologous to a putative…

A practical approach Searching the primaries Searching the secondaries Significance of database matches DB Web addresses Software Web addresses Why Search Databases? To find…

Protein secondary structure prediction methods TDVEAAVNSLVNLYLQASYLS âFrom sequence to structureâ What are they? Sequence-based tools for protein structure prediction.…

A practical approach Searching the primaries Searching the secondaries Significance of database matches DB Web addresses Software Web addresses Why Search Databases? To find…

Database Searching BLAST Database Searching Sequence Alignment Scoring Matrices Significance of an alignment BLAST, algorithm BLAST, parameters BLAST, output Alignment significance…

Protein secondary structure prediction methods TDVEAAVNSLVNLYLQASYLS âFrom sequence to structureâ What are they? Sequence-based tools for protein structure prediction.…

Proteins Proteins Chapter 5 Big Idea #2: Structure Meets Function Basic Unit of Proteins Amino Acid: Review: What are the constant domains of an amino acid? What is the variable…

Introduction to Phylogeny Cédric Notredame Centro de Regulacio Genomica Adapted from Aiden Budd’s Lecture on Phylogeny PRANK T-Coffee MAFFT M-Coffee Which MSA Method ?…