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1. Principles of Genome Analysis and Genomics Sandy B. Primrose Business and Technology Management High Wycombe Buckinghamshire, UK Richard M. Twyman Department of Biology…

Slide 1 Protein secondary structure prediction methods TDVEAAVNSLVNLYLQASYLS “From sequence to structure” Slide 2 What are they? –Sequence-based tools for protein structure…

Slide 1 Chapter 7 Molecular Organization of Chromosomes Slide 2 The range of genome sizes in the animal & plant kingdoms Slide 3 DNA can assume alternative conformations…

Slide 1 We have talked about chromosome organization, what about genome organization? Slide 2 Eukaryotic genomes are complex and DNA amounts and organization vary widely…

Slide 1 11 September, 2006 Chapter 6 DNA Structure Slide 2 Overview The classical DNA structure is an antiparallel duplex of polynucleotides. The two strands of DNA have…

Predicting protein disorder Peter Tompa Institute of Enzymology Hungarian Academy of Sciences Budapest, Hungary Why do we want to predict disorder ? Gap in knowledge (460…

Chapter 6 11 September, 2006 DNA Structure Overview The classical DNA structure is an antiparallel duplex of polynucleotides . The two strands of DNA have complementary sequence…

Primer extension * This labelling technique uses random oligonucleotides (usually hexadeoxyribonucleotide molecules- sequences of six deoxynucleotides) to primer synthesis…

Slide 1 Genome organization & its genetic implications Lander , ES (2011) Initial impact of the sequencing of the human genome. Nature 470:187 Feuillet, C, JE Leach,…