© 20 13 N at ur e A m er ic a, In c. A ll rig ht s re se rv ed . protocol nature protocols | VOL.8 NO.12 | 2013 | 2483 IntroDuctIon Chemical synthesis of proteins supports…

Slide 1 Protein Structure Slide 2 Why study protein structure? Studying the structure model allows better understanding of the structure-function relationship, and is an…

Slide 1 Protein-Misfolding Diseases PHY6940 April 8 th 2009 Jessica Nasica Slide 2 Overview of the presentation General facts on protein folding Causes of misfolding and…

Protein-Misfolding Diseases PHY6940 April 8th 2009 Jessica Nasica Overview of the presentation General facts on protein folding Causes of misfolding and protein aggregation…

Evolution and Scoring Rules Example Score = 5 x (# matches) + (-4) x (# mismatches) + + (-7) x (total length of all gaps) Example Score = 5 x (# matches) + (-4) x (# mismatches)…

Prediction of functional/structural sites in a protein using conservation and hyper-variation (ConSeq, ConSurf, Selecton) Empirical findings: variation among genes “Important”…