1.Large-scale analysis of the yeast proteome by multi dimensional protein identification technologyMichael P. Washburn, Dirk Wolters and John R. YatesNature BiotechnologyVolume…

Whole-Genome Analyses of Enterococcus faecium Isolates with Diverse Daptomycin MICs Lorena Diaz,a Truc T. Tran,b,c Jose M. Munita,b,d William R. Miller,b Sandra Rincon,a…

Slide 1 Orthology, and its relevance to protein function prediction Fitch 1970: “Where the homology is the result of gene duplication so that both copies have descended…

Slide 1 Zinc Uptake and Storage in Arabidopsis thaliana Chris Polo and Katie Gwathmey Slide 2 Benefits of Zinc Necessary for for high plant growth Functional subunit of Slide…

Sequencing of Mammalian Genomes Predicts 30,000 genes 2001 2002 What is the Proteome All the proteins expressed in a particular cell or tissue. By definition this will vary…

Whole Genome Assembly WGA 1. Screener 2. Overlapper 3. Unitigger, 4. Scaffolder, 5. Repeat Resolver. Overlapper ...looks for end-to end overlaps of at least 40 bp with no…

Bioinformatics of Protein Structure Protein structures often characterized by secondary structure content All a All b a/b a+b There are tools available (for instance at www.expasy.ch…

Improving the Sensitivity of Peptide Identification by Meta-Search, Grid-Computing, and Machine-Learning Nathan Edwards Georgetown University Medical Center Searching under…

Intro: Transcriptional regulatory networks RegulonDB: database with information on transcriptional regulation and operon organization in E.coli; 105 regulators affecting…

V12 Transcriptional regulatory networks RegulonDB: database with information on transcriptional regulation and operon organization in E.coli; 105 regulators affecting 749…