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Slide 1Molecular Pathogenesis of Leukemia PML/RAR  MLL translocations PLZF/RAR  etc. AML1/ETO CBF  /SMMHC TEL/AML1 Other transloc. BCR-ABL Flt3 ITD or mutation…

DNA Damage DNA damage DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per…

RESEARCH SUMMIT 2013 Precision Medicine A New Initiative The Concept of Precision Medicine (PM) The prevention and treatment strategies that take individual variability into…

Chapter 10 DNA damage and repair Defects in repair cause disease Common types of DNA damage DNA repair pathways Direct repair Base excision repair Nucleotide excision repair…

DNA damage, cellular sensing/responding and repair DNA Damage DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of…

First-principles simulations of the interaction of ionic projectiles with water and ice Jorge Kohanoff Atomistic Simulation Centre Queen’s University Belfast Toulouse,…

Slide 1 DNA damage, cellular sensing/responding and repair Slide 2 Slide 3 Slide 4 DNA Damage DNA damage, due to environmental factors and normal metabolic processes inside…

JB_322[6].inddJ. Biosci. 35(2), June 2010 1. Introduction order. The associated symptoms described earlier by Michail et al. (1957) were precisely delineated later as a syndrome