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Education p53

1. p53THE TUMORSUPPRESSOR Presented by Spoorthi shridhar MSc. biochemistry 2. INTRODUCTION• Tumor Suppressor• 53 kDa protein• Encoded by TP53 gene• Regulates cell…

Health & Medicine Molecular Genetics in MPN

1. General Pathogenesis of MyeloidneoplasmsClass I MutationsPROMOTE PROLIFERATION Class II MutationsBLOCKS DIFFERENTIATIONBCR-ABLFLT3JAK 2 etc…PML/RARAC/EBPA etcPROLIFERATIVE…