Slide 1Molecular dynamics simulations and membrane protein structure quality Anthony Ivetac and Mark S. P. Sansom European Biophysics Journal, Volume 37, Number 4, April…

Slide 110th lectureModern Methods in Drug Discovery WS06/071 Cytochrom P450, Polymorphism, Transporters Slide 2 10th lectureModern Methods in Drug Discovery WS06/072 Absorption…

Slide 1 1 Flow of information in a drug discovery pipeline Bioinformatics Computational and Combinatorial Chemisty Slide 2 2 Predictive ADME Absorption Distribution Metabolism…

Slide 1 branching at the  -carbon tends to destabilize an  -helix (Val, Thr, Ile) due to steric clashes, these aa are better suited to  -sheets where they stand…

Slide 1 Computational Methods for Protein Structure Prediction Ying Xu Slide 2 Outline introduction to protein structures the problem of protein structure prediction why…

Percentage of Domain Sequences in Genomes all excluding singletons excluding singletons And filtering Genome Coverage by Domain Superfamilies ~50% of domain sequences in…

Cytochrom P450, Polymorphism, Transporters Modern Methods in Drug Discovery WS08/09 Absorption and Metabolism Nutricients as wells as xenobiotics enter the blood circulation…

Cholera- and Anthrax-Like Toxins Are among Several New ADP-Ribosyltransferases Robert J. Fieldhouse, Zachari Turgeon, Dawn White, A. Rod Merrill* Department of Molecular…

Cytochrom P450, Polymorphism, Transporters Modern Methods in Drug Discovery WS10/11 Absorption and Metabolism Nutricients as wells as xenobiotics enter the blood circulation…

Cytochrome P450 Monooxygenases ubiquitous in nature: > 40 in humans > 250 in plants >400 in rice signature motif: FâG-R-C-G requires redox partner scission of O2…