Slide 1 Slide 2 What are proteins? Slide 3 Proteins are made up of C, H, O, N and some S and P Proteins are the building blocks of life There are millions of different proteins…

Slide 1 Novel labeling technologies on proteins Slide 2 ＋ h Protein 1 Protein 2 FRET Fluorescence h BFP GFP a) CFP YFP 14-3-3  Substrate peptide 433 nm 476 nm PKA +…

Slide 1 BLAST (Basic Local Alignment Search Tool) In addition to the exact word, BLAST considers related words based on BLOSUM62: the neighborhood. Once a word is aligned,…

Slide 1 Lecture 7.11 The Ensembl Database Erin Pleasance Steven Jones Canada’s Michael Smith Genome Sciences Centre, Vancouver Slide 2 Lecture 7.12 www.ensembl.org Slide…

Slide 1 Whole Genome Sequencing, Comparative Genomics, & Systems Biology Gene Myers University of California Berkeley Slide 2 A History of Genome Sequencing  1981:…

Slide 1 1 Protein-Protein Interaction Networks MSC Seminar in Computational Biology 19.1.2006 Slide 2 2 Proteins  From Greek – “proteios” – meaning “of first…

Slide 1 Heterochromatin distribution and function in interphase Grant Farr (Freitag Lab) Neurospora crassa image: N. B. Raju, Stanford University Slide 2 Long-term objectives…

Slide 1 Protein Structure Prediction Samantha Chui Oct. 26, 2004 Slide 2 Central Dogma of Biology Question: Given a protein sequence, to what conformation will it fold? DNA…

Slide 1 Proteomics: Analyzing proteins space Slide 2 Protein families Why proteins? Shift of interest from “Genomics” to “Proteomics” Classification of proteins to…

Slide 1 Biological Motivation Gene Finding in Eukaryotic Genomes Anne R. Haake Rhys Price Jones Slide 2 Recall from our previous discussion of gene finding in prokaryotes:…