Documents Alagille syndrome and non-syndromic paucity of the intrahepatic bile ducts

Alagille syndrome (ALGS) Overview and clinical manifestations In 1969, Daniel Alagille first described several families manifesting cholestatic jaundice, and went on to publish

Documents A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency

Mouse model of Alagille syndromeINTRODUCTION The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism, and mutations in its components