1. Analysis of metagenomes Lars Juhl Jensen EMBL Heidelberg 2. the challenge 3. the sheer amount of data 4.   5. what can we do with it? 6. function prediction 7. sequence…

Slide 1STRING Prediction of protein networks through integration of diverse large-scale data sets Lars Juhl Jensen EMBL Heidelberg Slide 2 STRING integrates many types of…

1.Systematic discovery of phosphorylation networks Combining linear motifs and protein interactions Lars Juhl Jensen EMBL Heidelberg2. Lars Juhl Jensen 3.   4.   5. promoter…

1.Network biology Large-scale data and text mining Lars Juhl Jensen 2. guilt by association 3. protein networks 4. STRING 5. computational predictions 6. gene fusion 7. Korbel…

1.Networks of proteins and diseases Lars Juhl Jensen 2. sequence analysis 3. protein networks 4. de Lichtenberg, Jensen et al., Science, 2005 5. adverse drug reactions 6.…

1.>10 km 2. too much to read 3. exponential growth 4. ~40 seconds per paper 5. computer 6. as smart as a dog 7. teach it specific tricks 8. information retrieval 9. named…

1.Network biology Large-scale data and text mining Lars Juhl Jensen 2. protein networks 3. medical networks 4. guilt by association 5. protein networks 6. STRING 7. functional…

1.Data and Text MiningLars Juhl Jensen2. sequence analysis 3. protein networks 4. de Lichtenberg, Jensen et al., Science, 2005 5. adverse drug reactions 6. Campillos, Kuhn…

1.The STRING database Lars Juhl Jensen EMBL Heidelberg2. data integration 3. Jensen et al., Drug Discovery Today: Targets, 2004 4. functional interactions 5. Bork et al.,…

1.Integration of biomedical literature and databases Lars Juhl Jensen EMBL Heidelberg2. why integration? 3. why biomedicine? 4. why literature? 5. why databases? 6. open…