Documents Phase I studies in non-oncology: Dosing & Designs April 18 th 2012 Sharon O’Byrne Senior Medical.....

Slide 1 Phase I studies in non-oncology: Dosing & Designs April 18 th 2012 Sharon O’Byrne Senior Medical Director Genentech Research & Early Development Slide 2…

Documents Pharma Midyear Reviewer.pdf

FIRST AND SECOND SHIFT PHARMACOLOGY REVIEWER PHARMACOKINETICS 1.Desired response and toxicity is a function of drug concentration. ABSORPTION 2.Cmax and Tmax affect RATE…