1. Molecular bases for metamorphosis H S GADAD PGS13 AGR 5965 2. OUTLINE• • • • • •Introduction Broad-complex transcription factors MicroRNA-dependent metamorphosis…

Slide 1 Slide 2  Dominant neurodegenerative disease  Polyglutamine repeat expansions (CAG, codon, Q) in exon 1 of huntingtin gene (htt). Usually >35 CAG repeats.…

Slide 1 Slide 2 Reverse Genetics: interference RNA Mitchell Bush Mimosa Chau Tayler Fluharty Slide 3 Slide 4 Summary Use RNAi to circumvent gene replacement difficulties…

RNA interference improves motor and neuropathologival abnormaliies in a Huntinton’s disease mouse model RNA interference improves motor and neuropathologival abnormaliies…

Slide 1 Reverse Genetics: interference RNA Mitchell Bush Mimosa Chau Tayler Fluharty Summary Use RNAi to circumvent gene replacement difficulties in Cryptococcus neoformans.…