Law of Mass Action When a drug (D) combines with a receptor (R), it does so at a rate which is dependent on the concentration of the drug and the concentration of the receptor.…

Physico-Chemical Properties of Drugs Physico-Chemical Properties of Drugs Exercise No. 1 Physico-Chemical Properties of Drugs Physical Chemical Solubility and Permeability…

Slide 1 Slide 2 Introduction The discovery of pharmacologic agents by modern pharmaceutical companies and universities often involves the use of receptor-ligand binding techniques.…

Slide 1 Hormone Receptors on the Plasma Membrane Characteristics of Receptors in General Five Groups of Membrane-Bound Receptors The G Protein-Coupled Receptor Superfamily…

Slide 1 The Organic Chemistry of Drug Design and Drug Action Chapter 3 Receptors Slide 2 1878Langley Study of antagonistic action of alkaloids on cat salivary flow suggests…

Farmakologi Molecular - Reseptor Farmakologi Molecular - Reseptor Receptor theory First postulated by John Langley (1878) Established after his experiments using nicotine…

PowerPoint Presentation Introduction The discovery of pharmacologic agents by modern pharmaceutical companies and universities often involves the use of receptor-ligand binding…

Drug Chemistry and Toxicology CHE 618 Alexander Nazarenko The Receptor Concept The Nature of Drug Receptors Drug Parameters: Affinity and Efficacy The Langmuir Isotherm equation…

Radioligand Binding Studies A radioligand is a radioactively labeled drug that can associate with a receptor, transporter, enzyme, or any site of interest. Measuring the…

Clinical Pharmacokinetics Dr. Norul Badriah Hassan Jabatan Farmakologi Pusat Pengajian Sains Perubatan Universiti Sains Malaysia Objectives 1. Drug-Response Relationship…