Slide 1Applications of relative free energy calculations Relative free energies are useful in two contexts: 1. Calculation of the free energy of binding of a ligand relative…

Nobel Prize® and the Nobel Prize® medal design mark are registrated trademarks of the Nobel Foundation 10 OKTOBER 2012 Scientific Background on the Nobel Prize in Chemistry…

Slide 1 Chapter 3 (part 2) – Protein Function Slide 2 Test Your Knowledge (True/False) All proteins bind to other molecules. Explain. What sort chemical interactions create…

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Slide 1 Towards Systematic Identification of cdiGMP Binding Proteins Kevin Roelofs Laboratory of Dr. Vincent Lee University of Maryland, College Park Slide 2 What is the…

Applications of relative free energy calculations Relative free energies are useful in two contexts: 1. Calculation of the free energy of binding of a ligand relative to…

Slide 1 Rationale : Endogenous lead compounds often simple and flexible (e.g. adrenaline) Fit several targets due to different active conformations (e.g. adrenergic receptor…

Oct 2010 SDMBT Lecture 8 Chromatography in proteomics Affinity Ion Exchange Reversed-phase * Oct 2010 SDMBT April 2006 * Principles of Affinity Chromatography Affinity chromatography…

Slide 1 Towards Systematic Identification of cdiGMP Binding Proteins Kevin Roelofs Laboratory of Dr. Vincent Lee University of Maryland, College Park What is the total regulatory…