MEDICINE OF THE FUTURE STEM CELLS AND GENE THERAPY
IN DIABETES
byProf Morsi Arab
University of Alexandria
The mature B-cells as a source (B-cell
transplantation ) is not satisfactory
because they are :
-Limited in number,
- have very limited proliferation capacity.
- and stimulating their growth by growth factors
diminishes their secretory power.
:Stages of Beta cell development and differentiation
- Fetal Entoderm. cell ( high growth potentiality)
- Panc. Duct epith. Cell
- Committed Endoc. precursor cell
- Growth Stimulated B-cell
- Mature B- cell (V. low division capacity)
GENE THERAPY and STEM CELLSin DIABETES
Gene Therapy is achieved in two steps
i. Prepare The Genetic Material +
ii. Delivery system
Non Embryonic Sources of Stem CellsAdult Bone Marrow Umbilical cord Stem Cells Amniotic Fluid Stem Cells Adult Mesenchymal Stem Cells*….etc
REPROGRAMMING ADULT CELLS BACK TO THE STEM
CELL STATE i.e. Inducing Pluropotency ))
The production of induced PluripotentStem (Cells ( iPSC
By genetic reprogramming of mature adult cells to go back to the pluripotent state (adding genes + transcription factors (TF)
New Developments in Stem Cells Research in Diabetes 2015
- In type 1 Diabetes pancreatic celldestruction results from inflammation + immune reaction
- Adult Mesenchymal Stem Cells ( MSCs) have potent anti- inflammatory and
immune suppressive power .
“Trafficking of Adult Mesenchyme Stem Cells and using Adhesive Molecules towards the Threatened
Pancreatic β cells
saves them from immune destruction”
Thank You
