Toxicity
• Clearly a critical issue– Small currents should not produce toxicity
• Currently testing for silver toxicity– Utilizing toxicity specialist at NCSU’s College of
Veterinary Medicine– Device has been design and fabricated– Testing will begin shortly
Test of Other Bacteria
• Currently testing super bugs– MRSA– VRE– C. Dif– Cipro-resistant e. coli– Asperillus– Acinetobacter baumannii– Pseudomonas aeruginosa
Long lasting and controlled release
• The hip implant would last for as much as 10 years running constantly• Ion release can be regulated by increasing or decreasing current• Device can be turned ON and OFF as required
An almost ready for market product
ACE treatment on a polycarbonate hard surface. Hospital cafeteria trays could be made very inexpensively using this concept almost immediately.
Other highly problematic targets
Keyboard Mouse
Many Touch Surface Opportunities
Technology Competitors
Safer, longer lasting, and more effective *BioguardCB
NANOVER TM
Animal Testing
Early Rat Testing Results
• 37 animals were used• 29 survived surgery and 1-2 weeks of recovery• 9 - 16 rats were used as control – all had
osteomyelitis• Developed the required protocol to infect a rat
tibia, and then install a device that was bactericidal
Animal Test Results
• Established a protocol for inserting our device into the tibia of Sprague Dawley rats
• Surgeries were performed without any antibiotic!
ACE Devices Used – First round of surgeries
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Battery
Silver Cathode(Ø 1mm)
Silver Anode
Flexible Wire (Insulated)Resistance
Epoxy Bubble
80 mm(approx.)
+
Battery
Copper Cathode(35 gage wire)
Silver Anode
Flexible Wire (Insulated)Resistance
Epoxy Bubble
80 mm(approx.)
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BatteryFlexible Wires
(Insulated)Silver Wire
(Anode)
Silver Paint (Cathode)
InsulationEpoxy Bubble 80 mm
(approx.)
Results2/3 rats were staph-free with this device. Problem, the device would frequently pierce through skin and organs.
0/6 rats were staph-free Problem, device floated uncontrollably.
1/3 rats were staph-free This device showed promise.
ACE Devices used – Second round of surgeriesResults
0/3 rats were staph-free Problem, the device fell a part.
1/3 rats were staph-free This design concept looked promising.
2/3 rats were staph-free This was a good device for future testing
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BatteryTeflon coated Silver wires
Anode
Cathode
ANODE(BARE SILVER WIRE)
CATHODE(35 GAGE COPPER WIRE)
1.4 V BATTERY
SILICONE ENCASING
20 mm
45 mm
4 mm
ANODE(BARE SILVER WIRE)
CATHODE(COATED SILVER WIRE)
1.4 V BATTERY
SILICONE ENCASING
Our Device in a living rat – First set of surgeries third device
Device designs
Some early rat testing
Rat tibia in agar with pseudomonas