BizInt Smart Charts 2014 1
Pharma-Bio-Med, Rome November 2014 Diane Webb, President
“Surfing the Pipeline” Comparing Drug Pipeline Database Coverage and Content
BizInt Smart Charts 2014 2
Ten Techniques to Visualize Clinical Trials
BizInt Smart Charts 2014 3
BizInt Smart Charts Product Family
Provides corporate information analysts with software tools to create reports and visualizations integrating information from their key sources.
BizInt Smart Charts 2014 4
“Cookbook” of techniques
• The Cookbook contains a collection of recipes to help you create accurate and appealing products from your raw ingredients.
• Step-by-step recipes illustrate how each tool can be used.
• Substitute ingredients as needed to answer your business questions.
BizInt Smart Charts 2014 5
Drug Pipeline Databases Provide data on drugs in development worldwide
• Citeline Pharmaprojects • IMS R&D Focus • Adis R&D Insight • Thomson Reuters Cortellis • Thomson Reuters Integrity Slides at www.bizint.com/slides
BizInt Smart Charts 2014 6
Case study: Hepatitis C Pipeline
Query: indication = Hepatitis C, all phases (exact query differs by database)
Records retrieved: Cortellis: 777 Integrity: 359 Pharmaprojects: 689 R&D Focus: 420 R&D Insight: 474 Import search results and use File|Combine
to create a single multi-database chart
BizInt Smart Charts 2014 7
Identify related records across databases
*
Tools | Generate Common Drug Name identifies records for the same drug by matching drug names and synonyms.
BizInt Smart Charts 2014 8
25%
15%
17%
29%
13%
45%
27%
31%
51%
23%
0% 10% 20% 30% 40% 50% 60%
Citeline Pharmaprojects
IMS R&D Focus
Adis R&D Insight
Thomson Reuters Cortellis
Thomson Reuters Integrity
% of Drugs vs. Records Retrieved from each Database (Indication = Hepatitis C)
% of Drugs (Total of all DBs)
% of All Records Retrieved
Database Coverage Analysis
* Drugs (Total of all DBs) identified using the “Generate Common Drug Name” tool.
*
BizInt Smart Charts 2014 9
Thomson Reuters Cortellis
35%
Citeline Pharmaprojects
29%
Adis R&D Insight 15%
IMS R&D Focus 17%
Thomson Reuters Integrity
Compounds 4%
Distribution of drugs found in a single database
BizInt Smart Charts 2014 10
Database Coverage by Phase (records)
64
182 127
194
93
92
113
114
127
171 64
25
49
102
52 84
100 149
144
43
385 35
210
0
100
200
300
400
500
600
700
800
All All All All All
Pharmaprojects R&D Focus R&D Insight Cortellis Integrity
# of Records by Highest Phase (for all indications )
No Dev Rep
Discontinued
Launched
Clinical
Discovery
BizInt Smart Charts 2014 11
Highest phase for indication of interest
We know the “Highest Phase” for all indications, but the phase for our indication of interest (Hep-C) is buried in the Drug Development Phase table.
BizInt Smart Charts 2014 12
Extracting the highest phase for Hep-C
Export to VantagePoint-Smart Charts Edition
BizInt Smart Charts 2014 13
Extracting the highest phase for Hep-C
Need to filter and clean-up indications.
BizInt Smart Charts 2014 14
Extracting highest phase for Hepatitis-C
Cleanup Hep-C indication
BizInt Smart Charts 2014 15
Extracting highest phase for Hepatitis-C
Filter the Drug Development Phase table to include only
the Hepatitis C entries.
BizInt Smart Charts 2014 16
Extracting highest phase for Hepatitis-C
Export to BizInt Smart Charts as a new column.
BizInt Smart Charts 2014 17
Extracting highest phase for Hepatitis-C
BizInt Smart Charts 2014 18
64 65
182 159 127 117 194 195
93 100
92 82
113 110
114 110
127 124
171 184 64 52
25 20 49
38
102 84
52 31 84
85
100 97
149 163
144 113
43 43
385 405 35 46
210 261
0
100
200
300
400
500
600
700
800
All Hep C All Hep C All Hep C All Hep C All Hep C
Pharmaprojects R&D Focus R&D Insight Cortellis Integrity
# of Records by Phase (for all indications and Hepatitis C)
No Dev Rep
Discontinued
Launched
Clinical
Discovery
Database Coverage by Phase (# of records)
BizInt Smart Charts 2014 19
Database Coverage by Phase (%)
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
All Hep C All Hep C All Hep C All Hep C All Hep C
Pharmaprojects R&D Focus R&D Insight Cortellis Integrity
Distribution of Records by Phase (for all indications and Hepatitis C)
No Dev Rep
Discontinued
Launched
Clinical
Discovery
BizInt Smart Charts 2014 20
Summarize differences between databases
BizInt Smart Charts 2014 21
Summarize differences between databases
Create a summary table with database, phase and
update date
BizInt Smart Charts 2014 22
Summarize differences between databases
Apply the “Summarize All Values” rule to the new
summary table
BizInt Smart Charts 2014 23
Summarize differences between databases
BizInt Smart Charts 2014 24
Analyze differences in phases (hep-c vs all)
Use “Compare Columns” to find drugs with different phase for Hep-C than for all indications
BizInt Smart Charts 2014 25
Analyze differences in phases (hep-c vs all)
Create a Bubble Graph in VP-SCE to spot trends
BizInt Smart Charts 2014 26
Analyze differences in phases (hep-c vs all)
Create a Bubble Graph in VP-SCE to spot trends
Marketed Drugs in Phase 2 for Hepatitis C
BizInt Smart Charts 2014 27
“Surfing the Pipeline” - conclusions
Pipeline databases continue to vary in coverage and content.
The more pipeline databases you use, the better you can exploit the strengths of each.
BizInt Smart Charts tools can help you aggregate, summarize and visualize multi-database pipeline information…
…to create more accurate and effective pipeline intelligence!
BizInt Smart Charts 2014 28
Visit our stand for more info and to see the
Cookbook!
www.bizint.com