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Type I has been defined as the low-barrier function group
Type II has been defined as the inflammation group with normal barrierfunction and inflammatory changes.
Type III has been specified as the pseudo-healthy group in terms ofnormal barrier function and no inflammatory changes
a high content of nerve growth factor has been observed in the stratumcorneum, relative to that of non-sensitive skin. Both in Types II and III,the sensitivity to electrical stimuli was high. As these data suggest, the
hypersensitive reaction of sensitive skin is closely related to nerve fibersinnervating the epidermis.
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can be defined in both subjective and objectiveterms. ubjective perceptions of sensitive skinare derived from patient observations regardingstinging, burning, pruritus, and tightness,following various environmental stimuli. Becauseof the lack of clinical signs, the phenomenon ofsensitive skin is difficult to document. Attemptsto identify clinical parameters in subjects withsubjective irritation indicate that theseindividuals tend to have a less hydrated, less
supple, more erythematous, and moreteleangiectatic skin, compared with the normalpopulation. In particular, significant differenceswere found for erythema and hydration!dryness
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Appro"imately #$% of the population
consider themselves to possess the
characteristics of sensitive skin, and &$% of
these patients with sensitive skindemonstrate these uncomfortable symptoms
without accompanying visible signs of
inflammation '(&)
*asil test sering tidak konsisten
http://informahealthcare.com/action/showPopup?citid=citart1&id=ch1-B35&doi=10.3109/9781420004601.001http://informahealthcare.com/action/showPopup?citid=citart1&id=ch1-B35&doi=10.3109/9781420004601.001
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+cema
Atopic dermatitis
osacea
( componen
'/)kin barrier disruption
'0)Immune hiper reactivity
'()*eightened neurosensory response
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1haracteried by itching, stinging, burning,possibly pain
An intact stratum corneum cannot preventthe development of alergic contac dermatitisin sensitied individuals
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Type / pimples and comedo-acne
0 flushing-rosasea
( burning and stinging!itching
# impaired barier, contact and iritant dermatitis
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reactive to wide variety of both endogenand e"ogen factor 22very sensitif skin
1lear,dry, thin, with tendencyto blush!flush
reaction to environmental factor 22environmentaly sensitif
Transiently reactive to spesific and definablecosmetic product 222cosmetically sensitif
skin
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'/) +asily disrupted barrier function notaccompanied by a rapid!intense inflamatoryrespon 222 delicate skin
'0) strong inflamatory response without asighnificant increase in T+34 222reactiveskin
'() height-end neurosensory perception tominor cutaneous stimulation22 stingers
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condition of subjective cutaneous
hyperreactivity to environmental factors
many ingredients of cosmetics such as
dimethyl sulfo"ide, benoyl pero"ide
preparations, salicylic acid, propylene glycol,
amyldimethylamino-benoic acid, and 0-
etho"yethyl metho"ycinnamate
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*yperreactors may have a thinner stratum corneumwith a reduced corneocyte area, causing highertranscutaneous penetration of water-solublechemicals which makes these subjects moresusceptible to chemical irritation.
imbalance of intercellular lipid of stratum corneum
changes in the nerve system and!or the structure ofthe epidermis
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5ain tructural and 6unctional7roperties 8sed to tudy Barrier6unctiona