LYSOSOMESLYSOSOMES
By: Carmelitta Oakley
LysosomesLysosomes
Characteristics:◦Acidic interior◦Contains hydrolytic enzymes◦Surrounded by a membrane
Lysosomes are analogous to the human stomach; the pH within a lysosome is very acidic & the enzymes within work most effectively in this environment.
Functions:Functions:Carrying out digestionrecycling of cellular organellesthe breakdown of viruses and other cellular
invaders
Single-celled organisms, such as amoebas, use lysosomes to digest their food since they have no process for extracellular digestion.
Lysosomal storage Lysosomal storage diseasesdiseases
Undegraded material accumulates within the lysosomes of affected individuals
Most of these diseases result from deficiencies in single lysosomal enzymes.◦Example: Gaucher’s disease
Gaucher diseaseGaucher diseaseMost common of lysosomal storage
diseases
Genetic disorder where there’s accumulation of lipids in cells and organs
results from a mutation in the gene that encodes a lysosomal enzyme required for the breakdown of glycolipids.
Some Signs & Symptoms:Some Signs & Symptoms:Enlarged liver and spleenLow number of red blood cells
(anemia)easy bruising caused by a decrease
in blood plateletslung diseasebone abnormalities such as bone
pain, fractures, and arthritis.Problems with central nervous
system