Excretory Pathways Naked
Lytic cycle Exocytosis
Enveloped
Dan StowellBotany Online Visual Resource Library
LJ001 an aryl methyldiene rhodanine derivative
A small anti-viral molecule effective against enveloped (but not naked) viruses.
Wolf et. al.
Broad Spectrum Influenza A Filoviruses Poxviruses Arenaviruses Bunyaviruses Paramyxoviruses Flaviviruses HIV-1 Hepatitis C Ebola And others
Viruses lack a ‘biogenic’ membrane
Viruses can’t make their own proteins or repair their membrane like a cell can
How we would use this Still very early in development, further
testing needed
Shorten Viral Infection Course Preventative Measure?
Could be put in condoms
New treatment for multiple viruses Eliminate temporary infections Fight Chronic ones
LJ001 is effective at very low doses Potentially Excellent Therapeutic Index
Sources (pictures not from papers)
Russell Kightley Media Virco Online Humanitarian Futures Programme Gary E. Kaiser HOPES (The Huntinton’s Disease
Outreach Project for Education) at Stanford
Molecular Station
Sources(papers)
Wolf et. al. A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3157-62. Epub 2010 Jan 28.
Balzarini J. Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy. Nat Rev Microbiol. 2007 Aug;5(8):583-97.
Kudchodkar S., Levine, B. Viruses and Autophagy. Reviews in Medical Virology. 2009; 19: 359-378
Melikyan GB. Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm. Retrovirology. 2008 Dec 10;5:111.