IntroductionIntroduction
Biochemize S.L.Biochemize S.L. is a biotechnological company focused in the design and development of processes based on biocatalysis.
Our technological platform lies in the use of enzymes or microorganisms to perform chemical reactions able to substitute manufacturing processes based on classical organic chemistry.
LocationLocation
We are located in Terrassa, at 20 km from Barcelona.
Our office and laboratories are part of the facilities of the Technology Centre of our associate partner Leitat.
Our TechnologyOur Technology
Biochemize S.L.Biochemize S.L. develops bioprocesses using biocatalysts (enzymes or microorganisms) in single or multiple transformation steps.
Our technological platform P2BP2B (Platform to Biochemize) is capable to perform high throughput screening of biocatalysts, reaction conditions, suitable substrates and products obtained.
The screening can be done in a short period of time and renders information about different possible bioprocesses and conditions that could be further developed at a larger scale.
P2B – P2B – Platform To BiochemizePlatform To Biochemize
P2BP2B is the key to determine quickly with low risk and at very small scale if a conceptual biotransformation is technologically viable.
Once the succeeding biocatalysts or bioprocesses have been identified, Biochemize S.L.Biochemize S.L. investigates at lab scale the experimental conditions which can lead to the highest yields.
Two approaches can be followed:
P2B BioprocessP2B Bioprocess
Development of bioprocesses suitable to substitute already established synthetic procedures up to an industrial scale
Perform biotransformations that can lead to a (new) chemical entity with improved features compared to the starting molecule
P2B DiscoveryP2B Discovery
P2B – P2B – DiscoveryDiscovery
P2B DiscoveryP2B Discovery is an ideal approach for molecules with a complex structure or different functional groups that can be affected when trying to modify them by synthetic procedures.
Biocatalysts can be used to obtain new lead, lead optimization, me-too and me-better compounds by modification of already available structures.
P2B – P2B – DiscoveryDiscovery
Directed
The type of transformation is selected based on the functional group or structure targeted.
Exploratory
The transformations applicable are diverse in orderTo test what kind of molecules can be obtained froma given starting structure or what kind of final properties may be achieved.
The biotransformation can be:
This approach is appropriate to seek new development opportunities (e.g. improved or different pharmacological properties)
This approach is suitable when it is well known what feature is conferred by the new functional group or structure in the final molecule (e.g. make it more soluble)
P2B – P2B – DiscoveryDiscovery Biotransformations Biotransformations
Oxidations / Reductions
Hydration / Dehydration
Glycosilations
Sulfidations / Sulfoxidations
Aromatic Chlorination
N-, O-, S-methylation
Nitrilation
Alkylation / Dealkylation
Amide and Ester formation / hydrolysis
Potentially, any biotransformation already described…
Applications of P2B – Applications of P2B – DiscoveryDiscovery
Evaluation of pharmacological properties
Improve the solubility
Source of building blocks
Obtain more stable molecules
Increase the IP of the company or the pipeline of products
Support in Analytical Methods development
More…
The P2B DiscoveryP2B Discovery process consists of the following phases:
Biotransform.Screening
BiocatalystSelection &
Reproduction
CompoundCharacteriz.
Small ScaleProduction
Flexible: Phases can be omitted, merged, delimited or adapted to each project or customer requirements.
Step-wise: Each phase is not planned nor quoted until the previous phase is completed and the results presented.
Risk-Control: The customer decides the project continuation at each phase depending on results and conclusions obtained so far.
Fast: The objective is to provide small amounts of promising (new) molecules in a short time, avoiding setting-up long, difficult and low yield synthetic procedures.
Results oriented: The customer is able to decide if full development is a business opportunity according to the properties tests of molecules provided.
Tests of Properties
by Customer
PHASE II PHASE III PHASE IV PHASE V
BibliographyAssessment
PHASE I
Project Management in P2B – Project Management in P2B – DiscoveryDiscovery
OperationsOperations
Biochemize S.L.Biochemize S.L. offers the most outstanding and up to date technology options, while maintaining an industrial scope.
If necessary, many operations can be outsourced to other companies and research centres under our direction and supervision.
We have a powerful network of contacts in biocatalysis and bioprocessing. Several partnership agreements have been established.
AustriaBulgariaChinaDenmarkIrelandItalyKoreaNetherlandsSpainUnited KingdomUnited States
AdvisorsAnalytical ServicesBiocatalyst SuppliersBioprocessing ServicesBiotransformation ExpertsEnzyme ScreeningEnzyme ImmobilizationGenetic EngineeringManufacturersResearch & DevelopmentScaling-Up Services
Why contracting Biochemize?Why contracting Biochemize?
We offer the most outstanding and up to date technology options.
Industrial scope guaranteed: productivity, costs and risks are the key drivers of our evaluations.
Our technology platform (P2BP2B) is a powerful tool for fast, low risk and small scale proof of concept verifications.
We increase the success possibilities through the P2BP2B platform and our network of contacts.
Project management based on a development by phases approach.
The customer controls the risks and costs associated to the project development.
ContactContact
Jaume Mir Founder
CEO and Commercial Director
E-mail: [email protected]
Telephone: ++34 686 441 120
Address: C/. de la Innovació, 2
(Leitat Centre Tecnològic)
88225 – Terrassa
(Barcelona) SPAIN
