Dept. of Pharmaceutics
1Vagdevi College Of Pharmacy & Research Center
Dept. of Pharmaceutics
ABOUT COMPANY
M/s. TWENTY FIRST CENTURY PHARMACEUTICALS PVT LTD., (TFCP) was incorporated on 21st March 1986.
The company has its facility at SIDCO ESTATE, AMBATTUR a suburb of CHENNAI, Tamil Nadu and at ROORKEE, Uttarakhand, India.
The company, as a matter of policy, focuses on only NICHE segments.
Mr. V.S. RAGHUNATHAN, a Technocrat with over 30 years of experience across pharma industry, financial institutions and businesses is the cheif executive.
The Roorkee Factory is 'the State of the art' facility incorporating USFDA / UK MHRA Standards.
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Dept. of Pharmaceutics
PRODUTS
Film Coated Tablets of Amoxycillin 875 mg + Clavulanic Acid 125 mg
Film Coated Tablets of Amoxycillin 500 mg + Clavulanic Acid 125 mg
Film Coated Tablets of Amoxycillin 250 mg + Clavulanic Acid 125 mg
Dispersible Tablets of Amoxycillin 200 mg + Clavulanic Acid 28.5 mg
Oral Suspension (Dry Syrup) of Amoxycillin 200 mg + Clavulanic Acid 28.5 mg
Bilayer Tablets of Cefixime 200 mg + Dicloxacillin 500 mg (Extended Release)
Film Coated Tablets of Cefixime 200 mg + Clavulanic Acid 125 mg
Film Coated Tablets of Cefixime 100 mg + Clavulanic Acid 62.5 mg
Dispersible Tablets of Cefixime 100 mg + Clavulanic Acid 62.5 mg
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Dept. of Pharmaceutics
Dispersible Tablets of Cefixime 50 mg + Clavulanic Acid 31.25 mg
Oral Suspension (Dry Syrup) of Cefixime 50 mg + Clavulanic Acid 31.25 mg
Film Coated Tablets of Cefadroxil 500 mg + Clavulanic Acid 125 mg
Dispersible Tablets of Cefadroxil 250 mg + Clavulanic Acid 62.5 mg
Oral Suspension (Dry Syrup) of Cefadroxil 125 mg + Clavulanic Acid 31.25 mg
Film Coated Tablets of Cefpodoxime 200 mg + Clavulanic Acid 125 mg
Film Coated Tablets of Cefpodoxime 100 mg + Clavulanic Acid 62.5 mg
Dispersible Tablets of Cefpodoxime 100 mg + Clavulanic Acid 62.5 mg
Oral Suspension (Dry Syrup) of Cefpodoxime 50 mg + Clavulanic Acid 31.25 mg
Film Coated Tablets of Cefuroxime 500 mg + Clavulanic Acid 125 mg
Film Coated Tablets of Cefuroxime 250 mg + Clavulanic Acid 62.5 mg
Dispersible Tablets of Cefuroxime 125 mg + Clavulanic Acid 31.25 mg
Oral Suspension (Dry Syrup) of Cefuroxime 125 mg + Clavulanic Acid 31.25 mg
We offer either individual molecules or in combination with Clavulanic Acid
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Dept. of Pharmaceutics
Twenty First Century Pharmaceuticals through their highly trained and dedicated staff
provide the bestsolution for your production and marketing needs.We believe that in
today's market we can add greatest value to our products by having an in depth
knowledge of your market place and provide the level of innovation and quality that you
need for success.Knowledge of Raw Materials, Active ingredients and Excipients are
recognized at Twenty First Century Pharmaceuticals, as critical in developing a
successful product.
All ingredients used are of the best quality and thorough analysis is
performed throughout the process.The need to ensure product integrity, the shelf life is
recognized as critical and stability checks are carried out as per I.C.H. guidelines as a
routine practice and the whole process is documented and traceability is ensured.
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Dept. of Pharmaceutics
INTRODUCTION
TABLET - SOLID DOSAGE FORM
Tablets are solid dosage form containing ingredients with or without filler material.
Based on the method of manufacture, can be classified as a printed tablet and compressed
tablet
Compressed tablets are made with high pressure in powder or granule using a steel mold
Printed tablet made by pressing the moist powder mass with low pressure into the mold
hole. The density of the tablet depends on the bond crystals formed during the drying
process, it has been very rarely used
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Dept. of Pharmaceutics
FORMS & CLASSIFICATION of TABLET
Based on the route of administration or its functions, drug delivery systems and forms
and methods of manufacture, the tablet can be classified as follows:
1. Oral tablets for Eaten
• Compressed Tablets / CT
• Double Layer/Multiple Compressed Tablets / MCT) -Coated Tablets -Felt a coated tablet • Tablet with repeated reaction
• Sugar coated and Sugar chocolate coated tablet
• Film-coated tablet
• Chewing Tablet
2. Tablets Used in Mouth cavity
• buccal tablet
• Sublingual Tablets
• Troche or lozenges
3. Tablet Provided by Other Routes
• Implantation Tablet
• Vaginal Tablets
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Dept. of Pharmaceutics
4. Tablets Used To Make Solvent
• effervescent tablets
• hypodermic tablet
• Triturat tablets
THE ADVANTAGES OF TABLET DOSAGE FORM
tablet is intact dosage form and offers the best capabilities of all oral dosage forms for
accuracy in size and content of the lowest variability
tablet dosage form which is the lowest cost of manufacture (if it is calculated per dose)
Tablets is an oral dosage form of the lightest, most compact, easiest and most inexpensive
way to packed and shipped
The product identification on the tablets the most easy and inexpensive, requiring no
additional work steps when using the printer surface that monogram or arising accesories
Tablet can be used as a product of specific release profiles, such as the release in the
intestine or slow release products
Tablets is an oral dosage form of the most easy to be produced in bulk (large scale)
THE DISADVANTAGES OF TABLET DOSAGE FORM
Some drugs can not be compressed into solid and compact, depending on its amorphous
state, flocculation, or low density.
Drugs moistened difficult, slow dissolves, moderate or high dose, high optimum
absorption via the gastrointestinal tract or any combination of the properties above, it
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Dept. of Pharmaceutics
would be difficult or impossible to be formulated and fabricated in the form of tablets
that produce sufficient drug bioavaibility
Medicine that tastes bitter, a drug with the smell was terrible and can not be eliminated,
or drugs that are sensitive to oxygen or air humidity needs to encapsulation or
compression cloaking before (if possible) or require coating first. In this case, the capsule
is a cheaper way out
Tablet properties
Tablets can be made in virtually any shape, although requirements of patients and
tableting machines mean that most are round, oval or capsule shaped. More unusual
shapes have been manufactured but patients find these harder to swallow, and they are
more vulnerable to chipping or manufacturing problems.
Tablet diameter and shape are determined by the machine tooling used to produce them –
a die plus an upper and a lower punch are required. This is called a station of tooling. The
thickness is determined by the amount of tablet material and the position of the punches
in relation to each other during compression. Once this is done, we can measure the
corresponding pressure applied during compression. The shorter the distance between the
punches, thickness, the greater the pressure applied during compression, and sometimes
the harder the tablet. Tablets need to be hard enough that they don't break up in the bottle,
yet friable enough that they disintegrate in the gastric tract.
Tablets need to be strong enough to resist the stresses of packaging, shipping and
handling by the pharmacist and patient. The mechanical strength of tablets is assessed
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Dept. of Pharmaceutics
using a combination of (i) simple failure and erosion tests, and (ii) more sophisticated
engineering tests. The simpler tests are often used for quality control purposes, whereas
the more complex tests are used during the design of the formulation and manufacturing
process in the research and development phase. Standards for tablet properties are
published in the various international pharmacopeias (USP/NF, EP, JP, etc.).
MANUFACTURING AND FORMULATION PROCESS
FORMULATION Film Coated Tablets of Cefixime 200 mg + Clavulanic Acid 125 mg +
Exicipents.
Manufacture of the tableting blend
In the tablet pressing process, the main guideline is to ensure that the appropriate amount
of active ingredient is in each tablet. Hence, all the ingredients should be well-mixed. If a
sufficiently homogenous mix of the components cannot be obtained with simple blending
processes, the ingredients must be granulated prior to compression to assure an even
distribution of the active compound in the final tablet. Two basic techniques are used to
granulate powders for compression into a tablet: wet granulation and dry granulation.
Powders that can be mixed well do not require granulation and can be compressed into
tablets through direct compression.
Wet granulation
Wet granulation is a process of using a liquid binder to lightly agglomerate the powder
mixture. The amount of liquid has to be properly controlled, as over-wetting will cause
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Dept. of Pharmaceutics
the granules to be too hard and under-wetting will cause them to be too soft and friable.
Aqueous solutions have the advantage of being safer to deal with than solvent-based
systems but may not be suitable for drugs which are degraded by hydrolysis.
Procedure
Step 1: The active ingredient and excipients are weighed and mixed.
Step 2: The wet granulate is prepared by adding the liquid binder–adhesive to
the powder blend and mixing thoroughly. Examples of binders/adhesives
include aqueous preparations of cornstarch, natural gums such as acacia,
cellulose derivatives such as methyl cellulose, gelatin, and povidone.
Step 3: Screening the damp mass through a mesh to form pellets or granules.
Step 4: Drying the granulation. A conventional tray-dryer or fluid-bed dryer
are most commonly used.
Step 5: After the granules are dried, they are passed through a screen of
smaller size than the one used for the wet mass to create granules of uniform
size. Low shear wet granulation processes use very simple mixing equipment,
and can take a considerable time to achieve a uniformly mixed state. High
shear wet granulation processes use equipment that mixes the powder and liquid at a very
fast rate, and thus speeds up the manufacturing process. Fluid bed granulation is a
multiple-step wet granulation process performed in the same vessel to pre-heat, granulate,
and dry the powders. It is used because it allows close control of the granulation process.
Dry granulation
Dry granulation processes create granules by light compaction of the powder blend under
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Dept. of Pharmaceutics
low pressures. The compacts so-formed are broken up gently to produce granules
(agglomerates). This process is often used when the product to be granulated is sensitive
to moisture and heat. Dry granulation can be conducted on a tablet press using slugging
tooling or on a roll press called a roller compactor. Dry granulation equipment offers a
wide range of pressures to attain proper densification and granule formation. Dry
granulation is simpler than wet granulation, therefore the cost is reduced. However, dry
granulation often produces a higher percentage of fine granules, which can compromise
the quality or create yield problems for the tablet. Dry granulation requires drugs or
excipients with cohesive properties, and a 'dry binder' may need to be added to the
formulation to facilitate the formation of granules.
Granule lubrication
After granulation, a final lubrication step is used to ensure that the tableting blend does
not stick to the equipment during the tableting process. This usually involves low shear
blending of the granules with a powdered lubricant, such as magnesium stearate or stearic acid.
Manufacture of the tablets
Whatever process is used to make the tableting blend, the process of making a tablet by
powder compaction is very similar. First, the powder is filled into the die from above.
The mass of powder is determined by the position of the lower punch in the die, the
cross-sectional area of the die, and the powder density. At this stage, adjustments to the
tablet weight are normally made by repositioning the lower punch. After die filling, the
upper punch is lowered into the die and the powder is uniaxially compressed to a porosity 12
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Dept. of Pharmaceutics
of between 5 and 20%. The compression can take place in one or two stages (main
compression, and, sometimes, pre-compression or tamping) and for commercial
production occurs very fast (500–50 msec per tablet). Finally, the upper punch is pulled
up and out of the die (decompression), and the tablet is ejected from the die by lifting the
lower punch until its upper surface is flush with the top face of the die. This process is
simply repeated many times to manufacture multiple tablets.
Common problems encountered during tablet manufacturing operations include:
poor (low) weight uniformity, usually caused by uneven powder flow into the die
poor (low) content uniformity, caused by uneven distribution of the API in the tableting
blend
sticking of the powder blend to the tablet tooling, due to inadequate lubrication, worn or
dirty tooling, and sub-optimal material properties
capping, lamination or chipping. Such mechanical failure is due to improper formulation
design or faulty equipment operation.
Tablet compaction simulator
Tablet formulations are designed and tested using a laboratory machine called a Tablet
Compaction Simulator or Powder Compaction Simulator. This is a computer controlled
device that can measure the punch positions, punch pressures, friction forces, die wall
pressures, and sometimes the tablet internal temperature during the compaction event.
Numerous experiments with small quantities of different mixtures can be performed to
optimise a formulation. Mathematically corrected punch motions can be programmed to
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Dept. of Pharmaceutics
simulate any type and model of production tablet press. Initial quantities of active pharmaceutical ingredients are very expensive to produce, and using a Compaction
Simulator reduces the amount of powder required for product development.
Tablet presses
The tablet pressing operation
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Dept. of Pharmaceutics
An old Cadmach rotary tablet pressTablet presses, also called tableting machines, range
from small, inexpensive bench-top models that make one tablet at a time (single-station
presses), with only around a half-ton pressure, to large, computerized, industrial models
(multi-station rotary presses) that can make hundreds of thousands to millions of tablets
an hour with much greater pressure. The tablet press is an essential piece of machinery
for any pharmaceutical and nutraceutical manufacturer. Common manufacturers of tablet
presses include Fette, Korsch, Kikusui, Manesty, IMA and Courtoy. Tablet presses must
allow the operator to adjust the position of the lower and upper punches accurately, so
that the tablet weight, thickness and density can each be controlled. This is achieved
using a series of cams, rollers, and/or tracks that act on the tablet tooling (punches).
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Dept. of Pharmaceutics
Mechanical systems are also incorporated for die filling, and for ejecting and removing
the tablets from the press after compression. Pharmaceutical tablet presses are required to
be easy to clean and quick to reconfigure with different tooling, because they are usually
used to manufacture many different products.Tablet coating.
Many tablets today are coated after being pressed. Although sugar-coating was popular in
the past, the process has many drawbacks. Modern tablet coatings are polymer and
polysaccharide based, with plasticizers and pigments included. Tablet coatings must be
stable and strong enough to survive the handling of the tablet, must not make tablets stick
together during the coating process, and must follow the fine contours of embossed
characters or logos on tablets. Coatings are necessary for tablets that have an unpleasant
taste, and a smoother finish makes large tablets easier to swallow. Tablet coatings are
also useful to extend the shelf-life of components that are sensitive to moisture or
oxidation. Special coatings (for example with pearlescent effects) can enhance brand
recognition.If the active ingredient of a tablet is sensitive to acid, or is irritant to the
stomach lining, an enteric coating can be used, which is resistant to stomach acid, and
dissolves in the less acidic area of the intestines. Enteric coatings are also used for
medicines that can be negatively affected by taking a long time to reach the small
intestine, where they are absorbed. Coatings are often chosen to control the rate of
dissolution of the drug in the gastrointestinal tract. Some drugs will be absorbed better at
different points in the digestive system. If the highest percentage of absorption of a drug
takes place in the stomach, a coating that dissolves quickly and easily in acid will be
selected. If the rate of absorption is best in the large intestine or colon, then a coating that
is acid resistant and dissolves slowly would be used to ensure it reached that point before dispersing.
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Dept. of Pharmaceutics
The Tablet Coating Process
Many solid pharmaceutical dosage mediums are produced with coatings, either on the
external surface of tablets, or on materials dispensed within gelatine capsules. Coating
serves a number of purposes:
Protects the tablet (or the capsule contents) from stomach acids
Protects the stomach lining from aggressive drugs such as enteric coated aspirin
Provides a delayed release of the medication
Helps maintain the shape of the tablet
Ideally, the tablet should release the material gradually and the drug should be available
for digestion beyond the stomach. The coating can be specially formulated to regulate
how fast the tablet dissolves and where the active drugs are to be absorbed into the body
after ingestion.
Many factors can affect the end-use properties of pharmaceutical tablets:
Chemical composition
Coating process
Drying time
Storage and environmental monitoring
Coating Process Design & Control
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Dept. of Pharmaceutics
Tablet coating takes place in a controlled atmosphere inside a perforated rotating drum.
Angled baffles fitted into the drum and air flow inside the drum provide means of mixing
the tablet bed. As a result, the tablets are lifted and turned from the sides into the centre
of the drum, exposing each tablet surface to an even amount of deposited/sprayed
coating.
The liquid spray coating is then dried onto the tablets by heated air drawn through the
tablet bed from an inlet fan. The air flow is regulated for temperature and volume to
provide controlled drying and extracting rates, and at the same time, maintaining the
drum pressure slightly negative relative to the room in order to provide a completely
isolated process atmosphere for the operator.
Tablet coating equipment may include spray guns, coating pan, polishing pans, solution
tanks, blenders and mixers, homogenizers, mills, peristaltic pumps, fans, steam jackets,
exhaust and heating pipes, scales and filters. Tablet coating processes may include sugar
coating (any mixtures of purified water, cellulose derivatives, polyvinyl, gums and sugar)
or film coating (purified water, cellulose derivatives).
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Dept. of Pharmaceutics
The coating process is usually a batch driven task consisting of the following phases:
Batch identification and Recipe selection (film or sugar coating)Loading/Dispensing (accurate dosing of all required raw materials)
WarmingSpraying (application and rolling are carried out simultaneously)
Drying
Cooling
Unloading
A control system must therefore provide flexibility in the way in which accurate and
repeatable control of the coating environment is achieved and will include the following
features:
Precise loop control with setpoint profile programming
Recipe Management System for easy parameterization
Sequential control for complex control strategies
Secure collection of on-line data from the coating system for
analysis and evidence
Local operator display with clear graphics and controlled access to parameters
The EyconTM Visual Supervisor is an ideal solution for the tablet coating process.
Types of Tablet Coating
Tablet coating means covering tablets with one or more than one layers of materials like
natural or synthetic resins ,gums ,inactive and insoluble filler, sugar, plasticizer,
polyhydric alcohol, waxes, authorized coloring material and some times flavoring
material. There are various types of tablet coating techniques which are described below :
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Dept. of Pharmaceutics
Sugar Coating
Sugar coating involves coating tablets with colored or uncolored sugar layer. This coating
is soluble in water and dissolves completely when swallowed. Apart from improving the appearance of the tablet, sugar coating makes it easy to imprint manufacturing
information on tablet. It increases the size and weight of the tablet. Sugar coating is a five
stage process involving following steps:
Sealing/water proofing
Sub coating
Grossing/smoothing
Coloring
Polishing Film Coating
In film coating, a thin layer of polymer is applied on the tablet core. Film coating
involves the use of film formers namely Hydroxy Propyl Methyl Cellulose
(HPMC),Methyl Hydroxy Ethyl Cellulose (MHEC),Ethyl Cellulose (EC),Hydroxy
Propyl Cellulose (HPC), Povidone,Sodium carboxy methyl cellulose,Polyethylene
glycols (PEG),Acrylate polymers.
Enteric Coating
The tablet core gets disintegrated in the environment, so to prevent disintegration, enteric
coating is used. This type of coating may be a one layer system or two layer system. It is
non toxic, cheap and resists gastric fluids.
Specialized Coating
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Dept. of Pharmaceutics
Compressed coating, electrostatic coating, dip coating, vacuum film coating are
specialized coating techniques involving the use of a special machine.
Coating Pan
Specially designed to apply seasoning to fried product in uniform manner
All contact parts are made of SS 304
Specification: 1 Hp Motor 3 phase
Weight: 75 Kg
Dimensions: 3 x 4 x 5 Ft
Capacity: 5-15 Kg per Batch
EQUIPMENTS
Autocoaters
Applications : Coater type SCS can be used to coat pallets, granules and tablets.
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Dept. of Pharmaceutics
Autocoaters are designed for the application of :
Film coating with organic solvent.
Film coating with aqueous coating.
Sugar coating.
Salient Features :
Automated process.
Conforms to cGMP.
Flexible batch operations.
Product protective handling to prevent chipping of tablets.
Complete separation of production and technical area.
These autocoaters or tablet autocoaters are extremely user friendly software and
operation through PLC.
Excellent mixing and tumbling by special design of baffles.
The autocoaters are made up of entirely of S.S.316.
Advanced CIP system.
Treatment of exhaust air for pollution free operation
LABORATORY DOUBLE ARM SIGMA BLADE MIXERS
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Dept. of Pharmaceutics
Laboratory Mixers are available in sizes ranging from 1/4 gallon to 3 gallon working
capacity. Variable speed drive on the blades standard. Stainless steel construction
standard, jacketed is standard.
Double Cone Blender
Our customers can avail from us Double Cone Blenders, which are highly efficient and
versatile machines, used in number of manufacturing and industrial applications. These
are used for mixing dry powder and granules homogeneously. Manufactured using finest
grade material, these are based on latest technology available in the industry. Offered at
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Dept. of Pharmaceutics
industry-leading prices, our products are used in food, pharmaceutical, cosmetic and
chemical industries.
Slugging Tablet Press
Dosage Form: Tablet
Type: Preparation Machinery
Applications
ZPW15A/B rotary tablet press can be used in a variety of applications. It is suitable not
only to the pharmaceutical and foodstuff industry but also the chemical, ceramic,
electronic and battery industry for pressing different granular materials into tablets.
Multi Punch Tablet Machine
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Dept. of Pharmaceutics
Features of our Multi Punch Tablet Machine: * Ground crank and gun
metal bushes. * Machine cut gears. * Easy to adjust. * Easy to
maintain. * Easy lubrication of grease only. * 1 HP 3 Phase electric
motor. * Speed 50 stroke/minute.
Tray Dryer
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Dept. of Pharmaceutics
1) CONSTRUCTION :
EXTERNAL:2MM THKINTERNAL:2MM THKMOC: cGMP
2) SURFACE FINISH : EXTERNAL:
Buffed to 150 grit matt finish INTERNAL: Buffed to 220 grit mirror finish.
3) INLET & OUTLET :
All pharmaceutical tray dryer and industrial tray dryer have a 5 micron pre filter at the inlet and a manually
infinite adjustable damper at the outlet.
4) DOOR : In these pharmaceutical tray dryer and industrial tray dryer doors at provided at the front and / or rear side of
the dryer. Door lips are lined with silicon rubber gasket to prevent any leakages. Suitable locking is
provided for the doors.
Tablet Compression / Coating Isolator
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Dept. of Pharmaceutics
Telstar Ace, has the experience in installation and commissioning of bespoke isolators to
contain a fully automated tablet presses and coaters.
The process of integrating the tablet press within an isolator starts with an ergonomic
model constructed around the press during the pre-engineering phase, enabling the client
and Telstar ACE to maximise the area's most important for operator production and maintenance.
Successful integration is a challenge, Telstar ACE a world leading containment specialist
enjoys and excels in this type of project, supplying containment solutions and bespoke
units to end users and OEM suppliers".
Portable Stirrer
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Dept. of Pharmaceutics
Varity of stirrers can fulfill the exact need of the production. These stirrers are different from traditional
stirrers
The telescopic construction enables complete extraction and insertion and
portable design assures multiple use of the stirrer.
PU wheels with turning facility make it easy to carry the stirrer anywhere on the shop floor.
Speed variation is controlled through VFD
STRIP PACKING MACHINE :
Is a high speed Packing suitable for a variety of products, such as tablets, dragees and
capsules. High quality sealing is achieved with features such as proportional temperature
controls, variable sealing roller pressure and rugged and precision construction.
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Dept. of Pharmaceutics
Blisterpack Machine
Automatic Blister Packing Machine(400 Blister/min)
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Dept. of Pharmaceutics
Multifunctional Automatic Alu-Alu Packing Machine
packaging machine ,packaging machinery ,drawing length driven by servo motor , with
high precision transmission....
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This KDB-240 is a high-speed double linesautomatic blister packing (Press Through Package (PTP)) machine.It automatically heats the PVC then forming,feeding, sealing, embossing, perforating &trimming.It can be used for the pharmaceutical packing(tablets, capsules, pills, and etc...), food and othersimilar products packing.Max. Capacity: 400 Blisters/Minute.
Dept. of Pharmaceutics
Strip Packaging
Strip packaging is a cost-effective packaging solution that enables small-sized tablets
and capsules to be packed in unit doses for distribution. Among the numerous packaging
solutions that Nutricap Labs offers, strip packaging is by far the most popular because of
its many unique advantages.
Benefits of Strip Packaging:
Strip packaging is economical.
Strip packaging provides your customers with organized packaging of their tablets or
capsules.
Strip packaging offers a more user-friendly packaging solution than bottled tablets and
capsules.
Strip packaging protects your product from physical and environmental damage during transit and storage.
Blister pack
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Dept. of Pharmaceutics
Blister pack is a term for several types of pre-formed plastic packaging used for small
consumer goods, foods, and for pharmaceuticals.
The primary component of a blister pack is a cavity or pocket made from a "formable"
web, usually a thermoformed plastic. This usually has a backing of paperboard or a
"lidding" seal of aluminum foil or plastic. A blister that folds onto itself is often called a
clamshell.
ALU PACKING
ALBLIS-I is a versatile ‘Flat Plate’ intermittent motion automatic Alu Alu Blister
Packing Machine that can produce Alu-Alu blister packs by cold forming method as well
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Dept. of Pharmaceutics
as PVC-Alu blister packs by thermoforming method. This Alu Alu Blister Packing
Machine is utilized for packing of smaller and regular shaped solid articles such as
pharmaceutical tablets, capsules, dragees etc., in Alu-Alu or PVC-Alu blister packs. This
Alu Alu Blister Packing Machine can also be used for packing of Ampoules, Vials, Tubes
as well as cream. paste, jam etc in PVC-Alu blister packs. The Blister Forming, Sealing,
Indexing and Punching operations are of intermittent reciprocating motion. Various types
and styles of product feeding devices are offered to suit different application.
The output capacity of the Alu Alu Blister Packing Machine depends on the product
characteristics and thus on the type of feeding device. Normally for cold forming
operation to produce Alu-Alu blisters this machine would operate at 25 cycles per minute
and for thermoforming operation to produce PVC-Alu blisters it would operate at 40
cycles per minute.
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Dept. of Pharmaceutics
CONCLUSION
This industrial visit is very useful to us as i have known about the
standards and procedures to be followed in the production,
Formulation, storage& packing of products.
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