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06th
June , 2014 Volume No.: 34 Issue No.: 02
Contents Message from GNI
Letter to the Edito News Update
Health awareness
Disease Outbreak N
Forth Coming Event
Drugs Update Campus News
Students Section
Editors Note
Archive
Vision
TO GROW AS A CENTRE OF EXCELLENCE IN THE FIELD O
PHARMACEUTICAL AND BIOLOGICAL SCIENCE
EDITOR: Jeenatara BegumGURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE
AND TECHNOLOGY
GNIPST Photo Gallery
For your comments/contributionORFor ack-Issues,
mailto:[email protected]
https://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=7mailto:[email protected]:[email protected]:[email protected]://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=78/12/2019 Gnipst Bulletin 34.2
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MESSAGE FROM GNIPSTGNIPST BULLETIN is the official publication of Guru Nanak
Institute of Pharmaceutical Science & Technology. All the
GNIPST members are proud to publish the 34th Volume ofGNIPST BULLETIN. Over the last three years this bulletin
updating readers with different scientific, cultural or sports
activities of this prestigious institute and promoting knowledge
of recent development in Pharmaceutical and Biological
Sciences. Students section is informing readers about some
curious facts of drug discovery, science, sports and other
relevant fields. All the viewers are requested to connect withtheir views, ideas and comments.
NEWS UPDATE
World Environment day: 5thJune
The United Nation General Assembly declared 2014 as theInternational Year of Small Island Developing States (SIDS).
The official slogan for the year 2014 is 'Raise Your Voice Not
The Sea Level.
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High blood pressure in middle age may affect
memory in old age (04thJune, 2014)
Researchers report that High blood pressure in middle ageplays a critical role in whether blood pressure in old age may
affect memory and thinking. The study found that the
association of blood pressure in old age to brain measures
depended on a history of blood pressure in middle age. Higher
systolic and diastolic blood pressure were associated with
increased risk of brain lesions and tiny brain bleeds. This was
most noticeable in people without a history of high bloodpressure in middle age.
Poor health, lifestyle factors linked to
memory complaints(04thJune, 2014)
Alzheimers disease, is the most common form ofdementia.
UCLA researchers and the Gallup organization polled more
than 18,000 people about their memory and a variety of lifestyle
and health factors previously shown to increase the risk of
Alzheimer's disease and dementia. They found that many of
these risk factors increased the likelihood of self-perceived
memory complaints across all adult age groups. The known risk
factors the researchers focused on included depression, lower
education levels, physical inactivity, high blood pressure,
diabetes, obesity and smoking. he researchers noted that, ingeneral, memory issues in younger people may be different from
those that plague older individuals. For younger adults, stress
may play more of a role, and the ubiquity of technology --
including the Internet and wireless devices, which can often
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result in constant multi-tasking -- may impact their attention
span, making it harder to focus and remember.
Hemorrhagic fevers can be caused by bodys
antiviral interferon response (04thJune, 2014)
Hemorrhagic fevers caused by Lassa, dengue and other viruses
affect more than one million people annually and are often fatal,
yet scientists, until now, have never understood why only some
virus-infected people come down with the disease and others
do not. Virologists and immunologists have found a major clue
to the mystery of hemorrhagic fever syndromes. The team
showed that Interferon Type I immune proteins are key drivers
of a viral syndrome in mice that closely mimics human
hemorrhagic fevers. "Blocking IFN-I signaling in certain genetic
mouse strains completely prevented disease signs such as
vascular leakage leading to death," While IFN-I proteins
traditionally have been considered essential for an effective
antiviral response and are still used to treat some chronic viralinfections, the new study suggests that these proteins
sometimes do much more harm than good -- and that blocking
them, or specific biological pathways they activate, might be a
good therapeutic strategy against hemorrhagic fevers.
Discovery of compound may open new road to
diabetes treatment (04thJune, 2014)
Researchers say the discovery of an inhibitor of the Insulin
Degrading Enzyme (IDE), a protein responsible for the
susceptibility of diabetes because it destroys insulin in the
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body, may lead to new treatment approaches for diabetes,.
More than 20 million people live with type II diabetes in the
United States, a disease in which the body cannot make
sufficient amounts of the hormone insulin.
Human stem cells successfully transplanted,
grown in pigs (04thJune, 2014)
In this study, the team of researchers implanted humanpluripotent stem cells in a special line of pigs. The pigs were
created with immune systems that allow the pigs to accept alltransplants or grafts without rejection. Once the scientistsimplanted the cells, the pigs did not reject the stem cells andthe cells thrived.
Heart disease without coronary plaque buildup
linked to heart attack risk (04thJune, 2014)"Unlike obstructive CAD, which blocks blood flow, non-
obstructive CAD may initially appear less threatening onangiography tests since it doesn't result in decreased bloodflow, but it appears to have significant risk for heart attack anddeath".Non-obstructive coronary artery disease was associated with a
28 to 44 percent increased risk of a major adverse cardiac event
such as a heart attack or death. The possible cause is that the
non-obstructive plaques can still rupture and cause heart
attacks. Providers and patients should take note of non-obstructive CAD and consider lifestyle changes and
medications that could help prevent it from causing future
adverse cardiac events such as heart attacks.
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Small-molecule drugs moved through blood-
brain barrier (04thJune, 2014)The blood-brain barrier is meant to protect the brain from
numerous undesirable chemicals circulating in the body, but it
also obstructs access for treatment of brain tumors and other
conditions. Too often the only recourse is invasive, which often
limits a drug's effectiveness or causes irreversible damage to an
already damaged brain. Nearly all of the drugs that could
potentially help are too large to normally pass through the
barrier. Additionally, other methods may damage the vascular
system. In this case, the synthetic peptide K16ApoE, onceinjected into a vein, binds to proteins in the blood to create
entities that can pass for near-normal ligands to some receptors
present on the blood-brain barrier. The 'pseudo-ligand' receptor
interaction creates what the researchers believe to be transient
pores through which various molecules can be transported to
the brain. The molecules they've transported in this manner
include cisplatin, methotrexate, cetuximab, three different dyes,and synthetic peptides Y8 and I-125.
Cell death clues may lead to disease treatment
(04thJune, 2014)The mechanism of necroptosis has been unraveled byreseachers. This is a type of cell death that plays a crucial role innumerous diseases, from viral infections and loss of auditorynerve cells to multiple sclerosis, acute heart failure and organtransplantation.
For detail mail to editor
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HEALTH AWARENESS
Brain CancerBrain cancer is a disease of the brain in which cancer cells
(malignant) arise in the brain tissue. Cancer cells grow to forma mass of cancer tissue (tumor) that interferes with brain
functions such as muscle control, sensation, memory, and other
normal body functions. Tumors composed of cancer cells are
called malignant tumors, and those composed of mainly
noncancerous cells are called benign tumors. Cancer cells that
develop from brain tissue are called primary brain tumors while
tumors that spread from other body sites to the brain aretermed metastatic or secondary brain tumors.
Causes:
Primary brain tumors include anytumor that starts in thebrain. Primary brain tumors can start from brain cells, themembranes around the brain (meninges), nerves, or glands.
Tumors can directly destroy brain cells. They can also damage
cells by producing inflammation, placing pressure on otherparts of the brain, and increasingpressure within the skull.
The cause of primary brain tumors is unknown. There are manyrisk factors that could play a role:
Radiation therapy used to treat brain cancers increases the riskof brain tumors up to 20 or 30 years later.
Some inherited conditions increase the risk of brain tumors,
including neurofibromatosis, Von Hippel-Lindau syndrome, Li-Fraumeni syndrome, and Turcot syndrome.
Lymphomas that begin in the brain in people with a weakenedimmune system are sometimes linked to infection by theEpstein-Barr virus.
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Exposure to radiation at work or to power lines, as well as headinjuries, smoking, and hormone therapy have not been provento be risk factors.
Studies have found that cell phones, cordless phones, and
wireless devices are safe and do not increase the risk.
SPECIFIC TUMOR TYPES
Brain tumors are classified depending on:
Location of the tumor Type of tissue involved Whether they are noncancerous (benign) or cancerous
(malignant) Other factors
Sometimes, tumors that start out less aggressive can changetheir biologic behavior and become more aggressive.
Tumors can occur at any age, but many types are most commonin a certain age group. In adults, gliomas and meningiomas arethe most common.
Gliomas come from glial cells such as astrocytes,oligodendrocytes, and ependymal cells. Gliomas are dividedinto three types:
Astrocytic tumors include astrocytomas (can be noncancerous),anaplastic astrocytomas, and glioblastomas.
Oligodendroglial tumors. Some primary brain tumors are madeup of both astrocytic and oligodendrocytic tumors. These are
called mixed gliomas. Glioblastomas are the most aggressive type of primary brain
tumor.
Meningiomas and schwannomas are two other types of braintumors. These tumors:
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Occur most often between ages 40 and 70. Are usually noncancerous, but can still cause serious
complications and death from their size or location. Some arecancerous and aggressive.
Other primary brain tumors in adults are rare. These include:
Ependymomas Craniopharyngiomas Pituitary tumors Primary (central nervous system - CNS) lymphoma Pineal gland tumors Primary germ cell tumors of the brain
Symptoms
Some tumors do not cause symptoms until they are very large.Other tumors have symptoms that develop slowly.
Symptoms depend on the tumor's size, location, how far it hasspread, and whether there is brain swelling. The most commonsymptoms are:
Changes in the person's mental function Headaches Seizures (especially in older adults) Weakness in one part of the body
Headaches caused by brain tumors may:
Be worse when the person wakes up in the morning, and clear
up in a few hours Occur during sleep Occur with vomiting, confusion, double vision, weakness, or
numbness Get worse with coughing or exercise, or with a change in body
position
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Other symptoms can include:
Change in alertness (including sleepiness, unconsciousness, andcoma)
Changes in hearing, taste, or smell Changes that affect touch and the ability to feel pain, pressure,
different temperatures, or other stimuli Confusion or memory loss Difficulty swallowing Difficulty writing or reading Dizziness or abnormal sensation of movement (vertigo) Eye problems such as eyelid drooping, pupils of different sizes,
uncontrollable eye movement, vision difficulties (includingdecreased vision, double vision, or total loss of vision)
Hand tremor Lack of control over the bladder or bowels Loss of balance or coordination, clumsiness, trouble walking Muscle weakness in the face, arm, or leg (usually on just one
side) Numbness or tingling on one side of the body Personality, mood, behavior, or emotional changes Trouble speaking or understanding others who are speaking
Other symptoms that may occur with apituitary tumor:
Abnormal nipple discharge Absent menstruation (periods) Breast development in men Enlarged hands, feet Excessive body hair Facial changes Low blood pressure Obesity Sensitivity to heat or cold
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Exams and Tests
The following tests may confirm the presence of a brain tumorand find its location:
CT scan of the head EEG Examination of tissue removed from the tumor during surgery
or CT-guidedbiopsy (may confirm the type of tumor) Examination of the cerebral spinal fluid (CSF) (may show
cancerous cells) MRI of the head
TreatmentTreatment can involve surgery, radiation therapy, andchemotherapy. Brain tumors are best treated by a team thatincludes:
Neuro-oncologist Neurosurgeon Medical oncologist
Radiation oncologist Other health care providers, such as neurologists and social
workers
Early treatment often improves the chance of a good outcome.Treatment depends on the size and type of tumor and yourgeneral health. Goals of treatment may be to cure the tumor,relieve symptoms, and improve brain function or comfort.
Surgery is often needed for most primary brain tumors. Sometumors may be completely removed. Those that are deep insidethe brain or that enter brain tissue may be debulked instead ofremoved. Debulking is a procedure to reduce the tumor's size.
Tumors can be hard to remove completely by surgery alone.This is because the tumor invades surrounding brain tissue
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much like roots from a plant spread through soil. When thetumor cannot be removed, surgery may still help reducepressure and relieve symptoms.
Radiation therapy is used for certain tumors.Chemotherapy may be used with surgery or radiation
treatment.
Other medicines used to treat primary brain tumors in childrenmay include:
Medicines to reduce brain swelling and pressure Anticonvulsants to reduce seizures Pain medicines
Possible Complications
Brain herniation (often fatal) Loss of ability to interact or function Permanent, worsening, and severe loss of brain function Return of tumor growth
Side effects of medications, including chemotherapy Side effects of radiation treatments
DISEASE OUTBREAK NEWS
Ebola virus disease (04thJune, 2014)
WHO and partners continue to support the implementation
of preventive and control measures in Ebola virus affectedcountries. WHO continues to provide guidance onpreparedness activities in accordance with the EVDpreparedness plans developed by each country. WHO doesnot recommend any travel or trade restrictions be applied to
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Guinea, Liberia, or Sierra Leone based on the currentinformation available for this event.Read more
FORTHCOMING EVENTS5th International Conference on Stem Cells and Cancer 2014,
JNU Convention Centre, New Delhi,India from 8-10
November.2014
DRUGS UPDATES
FDA approves first generic version of
Celecoxib(30thMay, 2014)
The U.S. Food and Drug Administration approved the firstgeneric versions of Celebrex (celecoxib) capsules, a treatmentfor rheumatoid arthritis, osteoarthritis, short-term (acute) pain,and other conditions. Teva Pharmaceutical Industries receivedapproval to market celecoxib capsules in 50 mg, 100 mg, 200mg, and 400 mg strengths, and has 180-day exclusivity on the
100 mg, 200 mg, and 400 mg strength products. MylanPharmaceuticals, Inc. received approval to market 50 mgcelecoxib capsules.Read more
CAMPUS NEWS
Reminiscence, 2014(GNIPST Reunion) was held in Collegecampus on 2ndFebruary,2014.
1stAnnual Sports of GNIPST was held on 3rdFebruary,2014 inCollege campus ground.
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An industrial tour and biodiversity tour was conducted inSikkim for B.Pharm and B.Sc. students under the supervision of
Mr. Asis Bala, Ms. Jeentara Begum and Ms. Moumita
Chowdhury.
B.Pharm 3rdyear won the GNIPST Football Champions trophy,2013. B.Pharm 3rdyear won the final match 1-0 against B.Pharm
2ndyear. Deep Chakrabortywas the only scorer of the final.
Students of GNIPST organized pre puja celebrationprogramme, Saaranya on 7th October, 2013 in college
Auditorium.
GNIPST organized a garment distribution programme on28th September, 2013 at Dakshineswar Kali Temple and
Adyapith, Kolkata. On this remarkable event about hundred
people have received garments. More than hundred students
and most of the faculties participated on that day with lot of
enthusiasm.
GNIPST celebrated World Heart Day (29thSeptember) andPharmacists Day (25th September) on 25th and 26th
September, 2013 in GNIPST Auditorium. A seminar on
Violence against woman and female foeticide was held on
GNIPST Auditorium on 25th September organized by JABALA
Action Research Organization. On 26
th
September an intra-college Oral and Poster presentation competition related to
World Pharmacists day and Heart day was held in GNIPST.
Ms. Purbali Chakraborty of B.Pharm 4th year won the first
prize in Oral Presentation. The winner of Poster presentation
was the group of Ms. Utsa Sinha, Mr. Koushik Saha and Mr.
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Niladri Banerjee (B.Pharm 4th year). A good number of
students have participated in both the competition with their
valuable views.
STUDENTS SECTION
WHO CAN ANSWER FIRST????
Which new word is derved from 2 Portugese
word for football and ecology ?
Name of which animal is derived from Spanish
word little armored one ?
Answer of Previous Issues QuestionsA) Ponds Cold cream B)Lifebuoy
Identify the person
Answer of Previous Issues ImageLever Brothers
Send your thoughts/ Quiz/Puzzles/games/write-ups or any other contributions for StudentsSection answers of this Section [email protected]
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EDITORS NOTE
I am proud to publish the 2nd
issue of 34th
Volume of GNIPST
BULLETIN. GNIPST BULLETIN now connected globallythroughfacebook account GNIPST bulletin
I want to convey my thanks to all the GNIPST members and
the readers for their valuable comments, encouragement and
supports.
I am thankful to Dr. Abhijit Sengupta, Director of GNIPST
for his valuable advice and encouragement. Special thanks to
Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar and Mr.Soumya Bhattacharya, Dipanjan Mandal for their kind co-
operation and technical supports. An important part of the
improvement of the bulletin is the contribution of the readers.
You are invited to send in your write ups, notes, critiques or any
kind of contribution for the forthcoming special and regular
issue.
ARCHIVE
Teachers daywas celebrated on 5thSeptember, 2013 by
the students of GNIPST in GNIPST Auditorium.
A zalea exotic flower ) , the fresher welcome programmefor newcomers of GNIPST in the session 2013-14 was held on8th August in GNIPST Auditorium.
One day seminar cum teachers development programme forschool teachers on the theme of Recent Trends of Life
Sciences in Higher Educationorganized by GNIPST held on
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29th June, 2013 at GNIPST auditorium. The programme was
inaugurated by Prof . Asit Guha, Director of JIS Group, Mr.
U.S. Mukherjee, Dy Director of JIS Group and Dr. Abhijit
Sengupta, Director cum Principal of GNIPST with lamp
lighting. The programme started with an opening song
performed by the B.Pharm students of this institute. The
seminar consists of a series of lectures, video presentations and
poster session. On the pre lunch session 4 lectures were given
by Dr. Lopamudra Dutta, Mr. Debabrata Ghosh Dastidar, Ms.
Swati Nandy and Ms. Tamalika Chakraborty respectively. On
their presentation the speakers enlighten the recent
development of Pharmacy, Genetics and Microbiology and theircorrelation with Life Sciences. On the post lunch session, Ms.
Saini Setua and Ms. Sanchari Bhattacharjee explained the
recent development and career opportunities in Biotechnology
and Hospital Management. The programme was concluded
with valedictory session and certificate distribution.
About 50 Higher secondary school teachers from different
schools of Kolkata and North& South 24 Parganas district ofWest Bengal participated in this programme. A good interactive
session between participants and speakers was observed in the
seminar. The seminar was a great success with the effort of
faculties, staffs and students of our Institute. It was a unique
discussion platform for school teachers and professional of the
emerging and newer branches of Life Science.
The general body meeting of APTI, Bengal Branch has been
conducted at GNIPST on 15th June, 2012. The program started
with a nice presentation by Dr. Pulok Kr. Mukherjee, School of
Natural Products, JU on the skill to write a good manuscript for
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publication in impact journals. It was followed by nearly two
hour long discussion among more than thirty participants on
different aspects of pharmacy education. Five nonmember
participants applied for membership on that very day.
GNIPST is now approved by AICTE and affiliated to WBUT for
conducting the two years post graduate course (M.Pharm) in
P H A R M A C O L O G Y .The approved number of seat is 18.The number of seats in B.Pharm. has been increased from 60 to
120.
AICTE has sanctioned a release of grant under Research
Promotion Scheme (RPS) during the financial year 2012-13to
GNIPST as per the details below:
a. Beneficiary Institution: Guru Nanak Institution of
Pharmaceutical Science & Technology.
b.Principal Investigator:Dr. LopamudraDutta.
c. Grant-in-aid sanctioned:Rs. 16,25000/- only
d. Approved duration: 3 yearse. Title of the project: Screening and identification of
potential medicinal plant of Purulia & Bankura districts of
West Bengal with respect to diseases such as diabetes,
rheumatism, Jaundice, hypertension and developing
biotechnological tools for enhancing bioactive molecules in
these plants.
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