Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Understanding the Intersection Between Information Technology
and the Life Sciences
The Terrain
Bob RoyceVP Business Development
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
I want to conquer death!
I don’t want to be sick!
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
What is Bio-IT?
Information Technology
LifeSciences
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
“Biology is an information science”
Leroy Hood, Michigan Life Science Core Technology Alliance Inauguration
In vivoIn silico
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
“the language of biology
is sounding increasingly like the language of
systems engineering”
103 of 341 MIT engineering school faculty use the term “bio” to describe the nature of their research.
Systems Biology at MIT: It’s All Over the Place By Adrienne Burke, Genome Technology editor-in-chief CAMBRIDGE, Mass., Jan. 9
MIT President Chuck Vest
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.Design Analysis
Optimization/Archive
Hypothesis -> ExperimentScientific Process Information
DNABiological Function
Genotype -> Phenotype
Biological Information
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
DNA: Where it all starts
Adenine Thymine
GuanineCytosine
The ultimate compression algorithm
A 4 letter code, 3 billion letters long…
… contains the recipe for building you and me
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Genomics to Proteomics
Computational Chemistry and Protein Folding Homology Modeling
BioinformaticsSequenceAnalysis
Chemical DB’s,CombinatorialChemistry,Docking studies
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
From Genotype to Phenotype
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Complex, Deeply Nested Layers of Data
QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
All this Produces an Information Explosion
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Partnerships/Collaborations
Internal
Public
Data Domain
Data Type
PastPast
Static Dynamic
moderate controlof data format
high level of controlof data format
FuturePresent
no direct controlof data format
…That must be managed in a both a Public and Private Context
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
“There does seem to be a disconnect between the value proposition and what is offered,”
“In 50 percent of the interactions that I have with vendors, they say, ‘We have a great technology that can help you…. Now tell me about drug discovery ’ ” Rainer Fuchs, vice president of research informatics at Biogen
Shawn Ramer, vice president of R&D informatics at Bristol-Myers Squibb
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Pharmaceutical R&D
$800 MFully CapitalizedCost to develop
$350 M SalesAvg. per year
Blockbusters (>$1B)Carry the rest...e.g. Lipitor
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Pharmaceutical R&D
Bio-IT Workshop: Positioning Your Firm. January 21, 2003
Conclusion
•Current focus is on applied technology…– Must understand the drug discovery process.
•Complexity of industry should not be underestimated
– Pace of discovery and innovation is staggering– Partnerships and alliances are key
•Nobody has the “right” model….– Everybody knows they need new ways to solve the
problem– Fragmentation in solution space makes it difficult to get
economies of scale for technology development
• But the goal is noble and the prize is large!