Binding to Complement: Humoral Immune Answer- Lysis of Opsonized Cells
Binding to Fc Receptors: Cellular Immune Response- Endocytosis- Secretion of Inflammatory Mediators
Antibodies are Central Mediatorsof the Immune Response
Huber, R., Deisenhofer, J., Colman, P.M., Matsushima, M., and Palm, W. (1976) Nature 264, 415-420
FcR/Fc-Wechselwirkung
Sondermann, Huber, Oosthuizen, Jacob (2000) Nature 406,267-273
P6522, a=b=115 Å, c=140 Å, ==90°, =120°
• Suppremol• Fc-receptors as therapeutic proteins
• in autoimmune diseases
• located in Martinsried, Germany
• founded in 2003
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FcR
Fc fragment
sFcR as Fc-Receptor Antagonists
Fc-Receptor
Specific antibody
Antigen
Immune complex
Unspecific antibody
Soluble Fc-Receptor
Activation
Fc-Receptor inhibitor
Inhibition
Soluble-FcR: Proof of Principle inanimal models
• Systemic Lupus Erythematodes (NZ B/W)
• Rheumatoide Arthritis (Collagen Induced)
• Multiple Sclerosis (EAE)
• Farmers Lung (Alveolitis)
sFcR bei Autoimmunerkrankungen
MS
PBSTryptophan-SynthaseFc-Rezeptor
Tage
Kan
khei
tsin
dex
SLEWochen
Übe
rleb
ensr
ate
Fc-Rezeptor
Kontolle
RA
Fc-Rezeptor
Kontolle
Tage
Kan
khei
tsin
dex
Alveolitis
PM
N x
108
RB
C x
108
Sondermann, Burkhardt, Schmidt, Linington, Jacob, unveröffentlicht
AK
AK
+O
VA
AK
+O
VA
+s
Fc
R
AK
AK
+O
VA
AK
+O
VA
+s
Fc
R
Sondermann, P., Huber, R., Oosthuizen, V. and Jacob, U. (2000). Nature 406, 267-273.Huber, R., Deisenhofer, J., Colman, P. M., Matsushima, M. and Palm, W. (1976). Nature 264, 415-420.
Structure of the complex of the soluble Fc-receptor and theFc-fragment of an IgG antibody
