What’s New in Research at What’s New in Research at the Anschutz Medical Campus: the Anschutz Medical Campus: Colorado Clinical Translational Colorado Clinical Translational Sciences Institute Sciences Institute Ronald J. Sokol, MD Ronald J. Sokol, MD Director Director Colorado Clinical and Translational Colorado Clinical and Translational Sciences Institute Sciences Institute Professor and Vice Chair Professor and Vice Chair Department of Pediatrics, SOM Department of Pediatrics, SOM Oct., 2007
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What’s New in Research at the Anschutz Medical Campus: Colorado Clinical Translational Sciences Institute Ronald J. Sokol, MD Director Colorado Clinical.
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What’s New in Research at the What’s New in Research at the
Colorado Clinical and Translational Sciences Colorado Clinical and Translational Sciences InstituteInstitute
Professor and Vice ChairProfessor and Vice Chair
Department of Pediatrics, SOMDepartment of Pediatrics, SOM Oct., 2007
CTSA Objectives: Speed Discoveries to CTSA Objectives: Speed Discoveries to Improved Patient CareImproved Patient Care
• Develop a Develop a distinct disciplinedistinct discipline for clinical and translational for clinical and translational science at institutions science at institutions
• Provide opportunities and resources for Provide opportunities and resources for original research on original research on novel methodsnovel methods
• Develop Develop translational technologiestranslational technologies and a knowledge base for and a knowledge base for the full spectrum of the full spectrum of clinical and translational scienceclinical and translational science
• Synergize partnershipsSynergize partnerships with industry, foundations, and with industry, foundations, and community physicianscommunity physicians
• Train the interdisciplinary teamsTrain the interdisciplinary teams who will conduct the clinical who will conduct the clinical and translational research of the futureand translational research of the future
BasicBasicResearchResearch
Clinical Clinical InvestigationInvestigation
Clinical TrialsClinical Trials
PracticePracticeIn the In the
CommunityCommunityT1T1
BenchBench BedsideBedside TrenchTrench
Bidirectional Translational ResearchBidirectional Translational Research
• Research Education, Training and Career Research Education, Training and Career Development Development
• Evaluation and TrackingEvaluation and Tracking
Why a Colorado CTSA?Why a Colorado CTSA?
• MustMust be part of CTSA national program to be part of CTSA national program to have a voice in CTS research, shape national have a voice in CTS research, shape national programsprograms
• Ability to attract and retain outstanding Ability to attract and retain outstanding faculty, trainees and physicians at all faculty, trainees and physicians at all affiliated institutions and campusesaffiliated institutions and campuses
• Provision of essential infrastructure, support Provision of essential infrastructure, support and improved trainingand improved training
• Be eligible for special NIH funding (RFAs)Be eligible for special NIH funding (RFAs)
Current CTS Research and Training Current CTS Research and Training Strengths at UCDHSC and CUStrengths at UCDHSC and CU
• Many successful collaborative Translational Many successful collaborative Translational research efforts across campuses research efforts across campuses
• Outstanding clinical research facilities (two Outstanding clinical research facilities (two General Clinical Research Centers and two General Clinical Research Centers and two satellites) and core resourcessatellites) and core resources
• Excellent community research programs Excellent community research programs (including Native American Health)(including Native American Health)
• One of first Clinical Science PhD and Masters One of first Clinical Science PhD and Masters programs in U.S.programs in U.S.
• Strong Child Health Research ProgramsStrong Child Health Research Programs
1. CTSA Planning Grant awarded in 20061. CTSA Planning Grant awarded in 2006• Funded – Funded – $150,000 direct costs $150,000 direct costs
$231,000 total costs$231,000 total costs
• Major critiques: Major critiques: – Expand scope to Expand scope to include more collaboration with include more collaboration with
CU BoulderCU Boulder – Physiology, – Physiology, bioengineeringbioengineering, etc., etc.– Evaluation process to assess outcomes resulting Evaluation process to assess outcomes resulting
from infrastructure changesfrom infrastructure changes
2. New2. New Colorado CST Institute (CCTSI) Colorado CST Institute (CCTSI)
approved by Regents in Aug. 2007approved by Regents in Aug. 2007
3. Grant application – Nov. 7, 2007 deadline3. Grant application – Nov. 7, 2007 deadline
Vision of CCTSIVision of CCTSI
Transform the current clinical and Transform the current clinical and
translational research and training efforts of translational research and training efforts of
all Schools at UCDHSC and affiliated all Schools at UCDHSC and affiliated
institutions into an innovative, institutions into an innovative,
academic home for clinical and translational academic home for clinical and translational
sciences, scientists and traineessciences, scientists and trainees
Mission of CCTSIMission of CCTSI
Improve the health of the population of Improve the health of the population of
Colorado by catalyzing the translation Colorado by catalyzing the translation
of biomedical discoveries into of biomedical discoveries into
prevention and intervention strategies prevention and intervention strategies
in the community, and by reducing in the community, and by reducing
health care disparitieshealth care disparities
Goals of Colorado CTSIGoals of Colorado CTSI
1.1. Transformation of the InstitutioTransformation of the Institution: n: UCDHSC will create the CCTSI as a UCDHSC will create the CCTSI as a visible, integrated and interdisciplinary visible, integrated and interdisciplinary statewide academic home for the statewide academic home for the disciplines of clinical and translational disciplines of clinical and translational sciences and research that will remove sciences and research that will remove barriers and obstacles and promote barriers and obstacles and promote successful careers successful careers
Goals of Colorado CTSIGoals of Colorado CTSI
2. Transformation of the Clinical and 2. Transformation of the Clinical and Translational Scientist:Translational Scientist:
The CCTSI will enhance, integrate and The CCTSI will enhance, integrate and transform training of translational transform training of translational scientists to develop a new generation scientists to develop a new generation of investigators with advanced of investigators with advanced degrees, interdisciplinary and degrees, interdisciplinary and collaborative skills and a team collaborative skills and a team approach to scientific investigation approach to scientific investigation
Goals of CCTSIGoals of CCTSI
3. 3. Transformation of Discovery Translational Transformation of Discovery Translational Research:Research:
The CCTSI will transform the performance of The CCTSI will transform the performance of discovery translational research (bench-to-discovery translational research (bench-to-beside research) by providing new resources beside research) by providing new resources and infrastructure, integrating current and and infrastructure, integrating current and developing new innovative research tools developing new innovative research tools and methodologies, catalyzing new and methodologies, catalyzing new interdisciplinary research programs and interdisciplinary research programs and removing barriers to efficiencyremoving barriers to efficiency
Goals of CCTSIGoals of CCTSI
4. Transformation of Community Translational 4. Transformation of Community Translational Research and PracticeResearch and Practice. .
The CCTSI will transform community and The CCTSI will transform community and population-based research by enhancing, population-based research by enhancing, extending and integrating community-based extending and integrating community-based participatory research into programs that will participatory research into programs that will engage community participation and develop engage community participation and develop novel methodologies for translation of novel methodologies for translation of scientific discoveries into clinical practicescientific discoveries into clinical practice