What Storing Cap is ?

Dox-al / MEDRO Meeting, Sharm el Sheikh, February 25th – 27th, 2013

Innovation in packaging

WHAT STORING CAP IS?


VITAL AMINESVITAMINS


THE HISTORY… - 1 Vitamin A: Retinoids & CarotenoidsVitamin B: initially considered only one vitamin, later recognized to be a groupVitamin C: Ascorbic acidVitamin D: initially considered only one vitamin, later recognized to be a group pf liposoluble pro-hormonesVitamin E: TocoferolsVitamin F: Fatty Acids(Omega-3 ed Omega-6)


Vitamin G: Riboflavine or Vitamin B2 (Belonging to B Group)Vitamin H: Biotin or Vitamin B8Vitamin I: Inositole or Vitamin B7Vitamin J: CholineVitamin K: Complex group (K from Deutch Koagulation)Vitamin L: Antranilic Acid (Triptophane metabolyte)Vitamin M: Folic Acid or Vitamin B9 or Vitamin Bc

THE HISTORY… - 2


Vitamin N: Alfa Lipoic Acid -ALA- (or Tiottic acid) Vitamin P: Bioflavonoides Vitamin PP: Niacin or Vitamin B3 , acronyme of Pellagra PreventiveVitamin Q: Ubiquinone or Coenzyme Q-10 Vitamin R: para-amino benzoic acid (PABA), or Vitamin B10 Vitamin S: pteroil-eptaglutamic acid or Vitamin B11

THE HISTORY… - 3


Vitamin T: TocotrienoliVitamin U: Methylmethionine o S-methyl-L-

methionine Vitamin V: not clearly identified.Vitamin W: Pantothenic acid or Vitamin B5 Vitamin X: not usedVitamin Y: PiridoxinVitamin Z: Zinc

THE HISTORY… - 4


THE FUNCTIONS… - 1

Hormone-like:• regulators of mineral metabolism (Vitamin D)• regulators of cell and tissue growth and

differentiation (some forms of Vitamin A)Antioxidants (Vitamin E and sometimes Vitamin C)


THE FUNCTIONS… - 2

Cofactors: as catalysts in metabolism(B complex vitamins)

Enzymes:as part of prostetic group: (Biotin is part of enzymes involved in making fatty acids)

Coenzymes: detachable molecules that function to carry chemical groups or electrons between molecules. (folic acid carries various forms of carbon group – methil, formyl, and methylene – in the cell


CHEMICAL NATURE – 1Vitamin Soluble

in WaterExposure

to AirExposureto Light

Exposureto Heat

Sensitiveto pH

Vitamin A no partially partially Relativelystable

Yesalkali

Vitamin C Veryunstable yes yes yes yes

Vitamin D no no no no Yesalkali

Vitamin E no yes yes no Yesacid

Vitamin K no no yes no yesThiamine

(B1) highly no ? > 100°C no

Riboflavin(B2) slightly no in solution no Yes

alkali


CHEMICAL NATURE - 2Vitamin Soluble

in WaterExposure

to AirExposureto Light

Exposureto Heat

Sensitiveto pH

Niacin (B3) yes no no no noPantothenic Acid (B5)

Quitestable ? ? yes Yes

acidVitamin B6 yes ? yes no Yes

acidBiotin (B7) somewhat ? ? no Yes

alkaliFolic Acid B9 yes ? when dry at high

tempyes

Vitamin B12 yes ? yes no no


VITAMIN C - BEHAVIOR

pH 7 T0 T30 T60 T90 T12025°C 10,00 9,20 7,40 6,60 5,6030°C 10,00 9,10 5,25 5,30 5,0040°C 10,00 9,10 5,00 4,70 4,30


pH 7 T0 T30 T60 T90 T12025°C 15,00 11,70 9,90 9,10 8,1030°C 15,00 11,50 7,30 6,40 6,0040°C 15,00 11,40 6,20 5,40 5,20

VITAMIN K - BEHAVIOR


pH 7 T0 T30 T60 T90 T12025°C 2,00 1,80 1,80 1,80 1,9030°C 2,00 1,90 1,80 1,90 1,8040°C 2,00 1,60 1,20 0,70 0,20

FOLIC ACID - BEHAVIOR


unit: MIU T0 T30 T60 T120 T360pH 3/RM 1.2 0.94 0.96 0.89 0.90

pH 3/30°C 1.1 0.93 0.92 0.82 0.90pH 3/40°C 1.2 0.89 0.90 0.83 0.81pH 7/RM 1.1 0.85 0.76 0.71 0.65

pH 7/30°C 0.98 0.81 0.83 0.70 0.52pH 7/40°C 0.99 0.8 0.70 0.51 0.45

exposed air 1.0 0.95 0.94 0.89 0.90

VITAMIN A - BEHAVIOR


unit: MIU T0 T30 T60 T120 T360pH 3/RM 1,00 0,97 0,92 0,90 0,89

pH 3/30°C 1,06 0,92 0,85 0,87 0,91pH 3/40°C 0,99 0,90 0,87 0,72 0,65pH 7/RM 0,96 0,88 0,81 0,84 0,85

pH 7/30°C 0,99 0,92 0,87 0,85 0,86pH 7/40°C 1,02 0,96 0,75 0,65 0,60

exposed air 1,02 0,94 0,65 0,41 0,35

VITAMIN D - BEHAVIOR


VITAMIN A – SAFETY DATA SHEET


VITAMIN D – SAFETY DATA SHEET


WHAT STORING CAP IS?

What Storing Cap is ?

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