UVLrx Blood Rejuvenation

†

62-0137-DM Rev A† As defined by UVL1500 Indications for Use. © 2017 UVLrx Therapeutics™, UVLrx Station™, UVLrx Treatment System™. All Rights Reserved. Patent(s) Granted / Pending. Model UVL1500 for export only. Not available in the United States. Statements not reviewed or approved by the FDA.

Ultimately, you want healthy patients who see results and grow healthier with each visit. The benefits of Blood Rejuvenation†, whether prescribed as primary or supplementary treatment is a giant leap forward in directly addressing symptoms, as well as with restorative and preventative health practices.

Reduce pathogens and reinvigorate blood on a direct cellular and sub-cellular level. The enormous benefits to your patients are far-reaching for many areas of practice. Blood rejuvenation is supportive to existing treatment plans for many diagnosed health issues. Also, as an option for doctors to add routine health maintenance protocols and services it ideally benefits diverse patient categories.

Leading the way in a revolutionary approach to overall health treatment...

UVLrx blood rejuvenation therapy is delivered intravenously by way of LED fiber optics using 3 distinctive wavelengths of light. Your blood never leaves the body and the experience is both gentle and relaxing.

0086Visible Red (630nm)• Immune System Modulation• Reduction of Inflammation• Improved ATP Synthesis (cellular “energy currency”)• Improved Wound Healing• Reduction of Pain

0086Visible Green (530nm)• Improved Blood Oxygen Transport• Improved Circulation• Improved Wound Healing• Improved ATP Synthesis (cellular “energy currency”)

0086

UVA (365nm)• Reduction of Pathogens in the blood • Improved ATP Synthesis (cellular “energy currency”)

Not to be confused with UVB and UVC rays. †As defined by UVL1500 Indications for Use. © 2017 UVLrx Therapeutics™, UVLrx Station™, UVLrx Treatment System™. All Rights Reserved. Patent(s) Granted / Pending. Model UVL1500 for export only. Not available in the United States. Statements not reviewed or approved by the FDA.

62-0137-DM Rev A

B L O O D R E J U V E N A T I O N†

Patient Treatment ExperienceThe treatment utilizes a standard 20 ga. x 1" I.V. site. The patient sits comfortably during the safe, sterile 60-minute treatment: • 30 minutes of Red + UVA• 30 minutes of Red + Green

The UVLrx System’s capability for simultaneous administration of I.V. fluids for hospitals, outpatient surgery centers, and private practice physicians, provides seamless integration with a variety of care requirements.

Why UVLrx _____________________

As a leader in blood rejuvenation therapy, The UVL1500 has enormous advantages, treating the entire passing blood supply versus the conventional treatment’s 5% maximum. It also delivers 3 wavelengths for multiple benefits versus just 1. The proprietary, minimally invasive LED fiber optics technology, delivers a comfort and ease that makes it a leading force among blood rejuvenation† technologies today.

• Added service: to virtually any prescribed course of treatment

• Recurring Service: Offer regular ongoing treatments to your patients for multiple health benefits.

• Reduced office time: The 3-wavelength system offers reduced visit time in one efficient unit compared to conventional treatments.

• Down time, die-off reactions: The UVL1500 unique delivery system gently “disables” pathogens from replicating in the bloodstream, minimizing die-off reactions and recovery.

The numerous restorative benefits to your patients are

far-reaching for many possible areas of practice

_____________________________infectious disease __________________________aesthetic recovery__________________________________________pain care_____________________________________ immunology______________________________general practice___________________________ vascular medicine________________________________________ cardiology______________________________________hematology _________________________________________anti-aging________________surgery / anaesthesiology__________________________________endocrinology _______________________ psychiatric medicine _____________________________ gastroenterology __________________________________ rheumatology __________________________________________ oncology___pulmonary / respiratory medicine______________________________________ orthopedics_______________________________ rhinitis / allergies_______________________________ sports medicine___________________ regenerative medicine_______________________ integrative medicine

† As defined by UVL1500 Indications for Use. © 2017 UVLrx Therapeutics™, UVLrx Station™, UVLrx Treatment System™. All Rights Reserved. Patent(s) Granted / Pending. Model UVL1500 for export only. Not available in the United States. Statements not reviewed or approved by the FDA.

62-0137-DM Rev A

B L O O D R E J U V E N A T I O N††

The incredible power of light0086

multifaceted synergistic approach to patient care

Improved ATP Synthesis

Improved Wound Healing

Reduction of Pain

Reduction of Pathogens in the blood

Reduction ofInflammation

Improved Blood Oxygen Transport

Improved Circulation

Immune SystemModulation

†As defined by UVL1500 Indications for Use

Visible GREEN

UVA

Visible RED


B L O O D R E J U V E N A T I O N†

If you think of your patient’s bloodstream like a systemic river of life, feeding every vital element to each cell in their body, then you recognize its vital importance to supporting all their major organs and systems.

The blood absorbs and delivers all the oxygen, nutrients, immune responses and medications to each organ and extremity. It transports collagen to heal wounds and delivers everything the cells need to function. However, we know the blood’s capabilities are adversely affected by an accumulation of wounds, environmental and dietary toxins, leading to numerous health complaints that are no longer self-correcting. So why not place a high priority on the well being of your patient’s blood? The importance of a strong focus on blood health is essential.

What can you do to rejuvenate your patient’s blood?You can begin by increasing cellular ATP synthesis and improving the body’s ability to heal, modulating the immuneresponse, improving both circulation and the blood’s rheological properties, increasing oxygen transport, reducing pathogens, and lowering inflammation and pain.

How you can help your patients:There are various ways you can address rejuvenating the blood.

1. Diet/Avoidance: Directing your patients towards an anti-inflammatory, mostly vegetarian diet and providing options to detoxify while avoiding added environmental toxins and minimizing trauma and disease is a sound course of action. Low to inconsistent compliance and external influences however, makes this generally impractical as a complete solution.

2. Utilization of intravenous light therapy (ILT). Light therapy has been used extracorporeally since the 1920s to a well documented and significant degree of success. However, recent innovative developments by UVLrx™, using

a patent pending LED engine and a proprietary delivery system has allowed the use of intravenous light directly to the bloodstream without extracting blood from the patient. This development has catapulted the technology to a new future in mainstream medicine, and allows for treatment of the entire passing blood supply versus conventional extracorporeal 5% restrictions. The treatment’s visible red, green and UVA wavelengths increase ATP synthesis in the

mitochondria and significantly improve the blood’s rheological properties to increase delivery to hard to reach areas. There is a streamlined convenience and ease of administering this 3-wavelength system to efficiently reduce pathogens in the blood, modulate the immune system and reduce inflammation all within one efficient treatment system.

“For the first time in my medical experience I have a compounded light therapy which has the ability to reduce inflammation, reduce pain, reduce blood pathogens, modulate the immune system, increase energy, improve wound healing, improve oxygenation and improve blood circulation. What diseased patient will not benefit from this therapy?”—Dr. Marc Phua, MD

The numerous benefits make ILT the most viable and safe blood rejuvenation treatment available. UVLrx Therapeutics’ proprietary LED engine and delivery system, make treatment more user-friendly, with the ability to administer more frequent treatments.

A rejuvenated blood and circulatory system has a profound effect on a patient’s health and well-being.

“Healthy blood, healthy body,”.

Dr. Michael Galitzer, MD,Author of the highly acclaimed book “Outstanding Health”


Why “blood rejuvenation† is the #1 most important thing you can do for your health”

“The most impactful, yet overlooked system, the bloodstream works

synergistically like an organ itself.”

“Blood Rejuvenation is a preventative and restorative solution for

potentially many areas of practice.”

ILT affects the blood’s rheological properties, making many hard-to-reach areas more accessible.

Michael Galitzer

UVLrx TherapeuticsTM

640 Brooker Creek BoulevardSuite 455, Oldsmar, FL 34677

www.UVLrx.com [email protected]: 844.UVL.RXRX

(844.885.7979)

UVL1500 System SpecificationsAC Input Supply: 100V – 240V, 50/60 HzMax Input Power: 48WDimensions (inches): 12 x 9.5 x 8.5Weight (lbs.): 10 max.Mounting: IV Pole or Table TopUser Interface: Touchscreen ControlRegulatory Clearances: CE 630912Patents Pending: US and International

Made in the USA

MDSS GmbHSchiffgraben 41D-30175 Hannover, Germany

certified0086

RED / Near-IR Light Stimulation Citations:Adenosine Triphosphate (ATP):1. Huang YY. Biphasic Dose Response in Low

Level Light Therapy. Dose Response. 2009; 7(4): 358–383.

2. Karu T. Mitochondrial Signaling in Mammalian Cells Activated by Red and Near-IR Radiation. Photochemistry and Photobiology, 2008, 84: 1091-1099.

Reduction of Inflammation:3. Aimbire F, Albertini R, Pacheco MT, Castro-

Faria-Neto HC, Leonardo PS, Iversen VV, Lopes-Martins RA, and Bjordal JM. 2006. Low-level laser therapy induces dose-dependent reduction of TNF alpha levels in acute inflammation. Photomed Laser Surg 24:33-7.

4. Alves ACA, Vieira R de P, Leal-Junior ECP, et al. Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation. Arthritis Research & Therapy. 2013;15(5):R116.

5. Ferreira DM, Zângaro RA, Villaverde AB, Cury Y, Frigo L, Picolo G, Longo I, Barbosa DG. Analgesic effect of He-Ne (632.8 nm) low-level laser therapy on acute inflammatory pain. Photomed Laser Surg. 2005 Apr;23(2):177-81.

6. Zhevago N, Samoilova K. Pro-and Anti-inflammatory Cytokine Content in Human Peripheral Blood after Its Transcutaneous (in Vivo) and Direct (in Vitro) Irradiation with Polychromatic Visible and Infrared Light. Photomed. Laser Surg. 2006;24:129-39.

7. Bjordal JM, Couppe C, Chow RT, Tuner J, and Ljunggren EA. 2003. A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders. Aust J Physiother 49:107-16.

8. de Morais NC1, Barbosa AM, Vale ML, Villaverde AB, de Lima CJ, Cogo JC, Zamuner SR. Anti-inflammatory effect of low-level laser and light-emitting diode in zymosan-induced arthritis. Photomed Laser Surg. 2010 Apr;28(2):227-32.

Wound Healing:9. Piva JA, Abreu EM, Silva Vdos S, Nicolau RA.

Effect of low-level laser therapy on the initial stages of tissue repair: basic principles. An Bras Dermatol. 2011 Sep-Oct;86(5):947-54.

10. Medrado AR, Pugliese LS, Reis SR, et al. Influence of low level laser therapy on wound healing and its biological action upon myofibroblasts. Lasers Surg Med 2003;32:239–44.

11. Whelan HT, Smits RL, Buchman EV, Whelan NT, Turner SG, et al. Effect of NASA light-emitting diode irradiation on wound healing. J Clin Laser Med Surg. 2001; 19(6):305–314.

12. Yu W, Naim JO, Lanzafame RJ. Effects of

photostimulation on wound healing in diabetic mice. Lasers Surg Med 1997;20:56–63.

13. Rodrigo SM, Cunha A, Pozza DH, Blaya DS, Moraes JF, Weber JB, de Oliveira MG. Analysis of the systemic effect of red and infrared laser therapy on wound repair: Photomed Laser Surg. 2009 Dec;27(6):929-35

14. Pereira AN, Eduardo Cde P, Matson E, et al. Effect of low-power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts. Lasers Surg Med 2002;31:263–7.

Circulation, Oxygenation, and Translation:15. Zhevago N, Samoilova K. Pro-and Anti-

inflammatory Cytokine Content in Human Peripheral Blood after Its Transcutaneous (in Vivo) and Direct (in Vitro) Irradiation with Polychromatic Visible and Infrared Light. Photomed. Laser Surg. 2006;24:129-39.

16. Mizutani K, Musya Y, Wakae K, Kobayashi T, Tobe M, Taira K, et al. A Clinical Study on Serum Prostaglandin E2 with Low-Level Laser Therapy. Photomed Laser Surg. 2004;22:537-9.

17. Mi X, Chen J, Cen Y, Liang Z, Zhou L. A comparative study of 632.8 and 532 nm laser irradiation on some rheological factors in human blood in vitro. J. Photochem. Photobiol. B., 2004; 74,1:7-12

18. Hegedus B, Viharos L, Gervain M, Gálfi M. The Effect of Low-Level Laser in Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Trial. Photomedicine and Laser Surgery. 2009;27(4):577-584.

Immune System Modulation and Reduction of Pathogens in the Blood:

19. Tadakuma T. Possible application of the laser in immunobiology. Keio J Med. 1993 Dec;42(4):180-2.

GREEN Light Stimulation Citations:

Adenosine Triphosphate (ATP):20. Kassak P, Przygodzki T. Mitochondrial

alterations induced by 532nm laser irradiation. Gen. Physiol. Biophys. (2005), 24, 209-220.

21. P. KAŠŠÁK, L. ŠIKUROVÁ, P. KVASNIČKA, M. BRYSZEWSKA. The Response of Na+/K+-ATPase of Human Erythrocytes to Green Laser Light Treatment. Physiol. Res. 55: 189-194, 2006.

Reduction of Inflammation:22. Zhevago N, Samoilova K. Pro-and Anti-


Wound Healing:23. Tanno Y, Mahmood A. Liver Repair in Rabbits

Using 532 nm Nd:YAG Laser; In Vivo Study. Iraqi J. Laser, Part B, Vol.10, No.1, pp. 25-30 (2011)

24. Fukuzaki Y, Sugawara H, Yamanoha B, Kogure S. 532 nm Low-Power Laser Irradiation Recovers y-Secretase Inhibitor-Mediated Cell Growth Suppression and Promotes Cell Proliferation via Akt Signaling. PLoS One. 2013 Aug 7;8(8)

25. Vinck E, Cagnie B, Cornelissen M, Declerque H, Cambier D. Green light emitting diode Irradiation enhances Fibroblast Growth impaired by high glucose levels. Photomedicine and laser surgery. 2005, 23, 2:167-171

Circulation, Oxygenation, and Translation:26. Zhevago N, Samoilova K. Pro-and Anti-


27. Mizutani K, Musya Y, Wakae K, Kobayashi T, Tobe M, Taira K, et al. A Clinical Study on Serum Prostaglandin E2 with Low-Level Laser Therapy. Photomed Laser Surg. 2004;22:537-9.

28. Mi X, Chen J, Cen Y, Liang Z, Zhou L. A comparative study of 632.8 and 532 nm laser irradiation on some rheological factors in human blood in vitro. J. Photochem. Photobiol. B., 2004; 74,1:7-12

29. Schwengel RH, Gregory KW, Hearne SE, Scott HJ, Beauman GJ, Mergner WJ, Caplin JL, Ziskind AA. Characterization of pulsed-dye laser-mediated vasodilatation in a rabbit femoral artery model of vasoconstriction. Lasers Surg Med 1993;13: 284–295.

UVA Light Stimulation Citations:

Adenosine Triphosphate (ATP):30. Müller-Enoch D. Blue light mediated

photoreduction of the flavoprotein NADPH-cytochrome P450 reductase. A Förster-type energy transfer. Z Naturforsch C. 1997 Sep-Oct;52(9-10):605-14.

Immune System Modulation and Reduction of Pathogens in the Blood:

31. Hallet MB, Lloyds D. Neutrophil priming: the cellular signals that say ‘amber’ but not ‘green’. Immunol Today. 1995 Jun;16(6):264-8

32. Jiang F, Shang Y. NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repair. Pharmacol Rev. 2011 Mar;62(1):218-42.

33. Artyukhov VG, Iskusnykh AY. Effect of UV irradiation on functional activity of donor blood neutrophils. Bull Exp Biol Med. 2005 Mar;139(3):313-5.

34. El-Benna J, Danq PM. Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane. Semin Immunopathol. 2008 Jul;30(3):279-89.

Clinical Citations and References

ISO13485

62-0137-DM Rev A

† As defined by UVL1500 Indications for Use. © 2017 UVLrx Therapeutics™, UVLrx Station™, UVLrx Treatment System™. All Rights Reserved. Patent(s) Granted / Pending. Model UVL1500 for export only. Not available in the United States. Statements not reviewed or approved by the FDA.

Optical OutputUV Wavelength: 1000 uW/cm2 Red Wavelength: 270 uW/cm2 Green Wavelength: 225 uW/cm2

UVLrx Blood Rejuvenation

Documents