Of the top 10 gastrointestinal drugs with the highest reported adherence on Medisafe, GSK and Shire hold two spots each. Gastroesophageal Reflux Disease Heartburn Gastroesophageal Reflux Disease Diuretic Ulcerative Colitis Nausea, Vomiting Irritable Bowel Syndrome Nausea, Vomiting Irritable Bowel Syndrome Ulcerative Colitis Dexilant Prevacid Protonix Lasix Lialda Zofran ODT Linzess Zofran Bentyl Pentasa Takeda GlaxoSmithKline Pfizer Validus Shire Novartis Allergen GlaxoSmithKline Forest Labs Shire Brand Condition Company 79% 79% 79% 81% 79% 75% 75% 76% 78% 74% Adherence ? ( 1;754C 4% Worried about side effects 1% Worried about cost 7% Ran out of meds 27% Forgot/med not nearby 40% Didn’t need dose 21% Other The highest GI adherence rates on Medisafe are in the morning hours, then decrease throughout the day until the night hours. 6 4 5 7 8 9 10 11 1 2 1 2 3 4 5 6 7 8 9 10 AM PM 75% 70% 65% 60% 55% Canada Mexico USA 77% UK 77% 78% Brazil 77% 82% Italy 81% 75% 79% Australia 77% Germany Turkey Germany and Italy lead other nations in reported gastroenterology adherence on Medisafe. S M T T W F S 77% 77% 78% 76% 76% 74% 74% Like many therapeutic areas, Saturday and Sunday prove the most challenging for GI medication adherence. 50% Average adherence across all therapeutic classes without Medisafe 2 80% 79% 77% 76% 75% 74% 73% 71% Esophagitis | Duodenal Ulcer Diarrhea | Ascites Dyspepsia Crohn’s Disease | Gastroenteritis Constipation | Bile Acid Seqauestrants Irritable Bowel Syndrome Pancreatic Diabetic Gastroparesis Worldwide medication adherence rates for most gastroenterology conditions are 75% or higher on Medisafe. K9K Q3K 81% P4K 80% O5K 79% L8K 76% 75% J:K 74% Top GI Companies by Highest Adherence Top GI Meds with Highest Adherence Adherence Rates by Type of GI Treatment How Day of Week Affects GI Adherence Most Adherent Countries for Gastroenterology Meds Medisafe Reported Gastrointestinal Drug Adherence By Company Medisafe Reported Gastrointestinal Drug Adherence by Drug Name 5 Medisafe Reported Gastrointestinal Drug Adherence By Condition Medisafe Reported Gastrointestinal Drug Adherence by Geography Medisafe Reported Gastrointestinal Drug Adherence By Day How Hour of Day Affects GI Adherence Medisafe Reported Gastrointestinal Adherence by Hour Why Gastrointestinal Patients Say They Miss Doses Medisafe GI Patients’ Reasons for Skipping a Dose Medisafe, the leading personalized medication management platform addressing all major causes of non-adherence, delivers better medication adherence 1 , with more than 750M doses managed. Gastroenterology Adherence Data: Real-time stats on Medisafe that pharma should know Medisafe is the leading personalized medication management platform addressing all major causes of non-adherence. Far more than a pill reminder app, Medisafe is a cloud-based platform that personalizes content, resources and interventions — such as educational videos, coupons and motivational messages — based on each user’s regimen, condition and specific circumstance. Visit medisafe.com/pharma for more information. 1) Medisafe demonstrates up to 20% increase in med adherence in IMS study, presented at ISPOR. 2) Medication Adherence in developed countries averages 50%, and is lower in developing regions (WHO). Source: http://www.who.int/chp/knowledge/publications/adherence_full_report.pdf 3) Medisafe reported adherence of active users that approved notification with more than 3 doses taken from the first take to the last take in relation to scheduled doses. 4) Patients are generally considered adherent to their medication if their medication adherence percentage, dened as the number of pills absent in a given time period (“X”) dividedby the number of pills prescribed by the physician in that same time period, is greater than 80%. (NIH). Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068890/#R6 5) Some gastroenterology medications are only infused at a medical center or physician’s office over weekly or monthly intervals, and thereby not represented in this adherence data. Find out how you can get behavioral insights and answers from the 4 million patients who are using Medisafe’s medication management platform. Looking for additional insights? medisafe.com/insights