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Problem-Based Learning (PBL)
Tutorial 1Scenario 1
Group 4
Member :
1. Mellyana 540810010022. Febriana Qolbi 540810010153. Aisyah Triansari 540810010274. Feblin Versiliantina 540810010295. Ginda Chitra Puspita 540810010306. Tiara Anggita Q 540810010347. Aulia Shahnaz 540810010648. Gerry Irawan 540810010959. Likoh 5408100109910. Joande Necisa 5408100110211. Nevinia Ann A/P Robert 54081001110
Medical Faculty Sriwijaya University
2008 - 2009
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Scenario D
Mrs. Fatimah, 70 years old, 43 kilograms body weight, 165 centimeters height, came to
your practice room with complaints of pain to spine for 7 days duration. There were no
recognizable factors which might have precipitated the pain, and the symptoms seemed to
appear spontaneously. No definite history of antecedent trauma or pre-existing disease was
obtained. The episode of pain began gradually. The pain became more severe over a period
of 2 weeks to a month. Morning stiffness was not present. She still lives alone and always
consumed coffee. I am a smoker so I must drink coffe more than common people. She
had got menopause since 20 years ago.
From physical examination is completely notrmal. Her lumbosakral radiologic examination
was compresi fracture on L2-L5. Densitometri from femur : T Score -4, from radius : -3.7
I. Term Clarification
Pain to spain
Pain in vertebral coloumn
Antecedent trauma / pre existing disease
A trauma / disease yang di dahului trauma sebelumnya
Morning stiffness
Difficulty in moving the joint or stretching a muscle in the morning
Menopause
The time in a womans life when the ovaries cease to produce an egg cell
every 4 weeks
Lumbosakral Radiologic
Radiology of relating to part of the spine composed of the sacrum
Densitometri
An imaging techique that uses low-dose X-rays to measure bone density
Compresi fracture
II. Problem Identification
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1. Mrs. Fatimah, 70 years old, 43 kilograms body weight, 165 centimeters height,
complaints of pain to spine for 7 days duration, pain spontaneously, no
recognizable factors which might have precipitated the pain, no definite history of
antecedent trauma, the pain became more severe over a period of 2 weeks to a
month.
2. She still lives alone and had got menopause since 20 years ago
3. She always consumed coffee and a smoker
4. From physical examination is completely notrmal. Her lumbosakral radiologic
examination was compresi fracture on L2-L5. Densitometri from femur : T Score
-4, from radius : -3.7
III. Problem Analysis
1. a. What is the BMI of Mrs. Fatimah?
Berat badan normal = TB 110 (untuk TB > 160cm)
= 165 110 = 55kg
Berat badan ideal menurut Broca = (TB - 100) 10% (TB - 100)
= (165 - 100) 10% (165 - 100)
=58.5 kg (dengan batas ambang 10%)
BMI = BB / TB2 = 43 kg / 1.65 = 26.06
b. What is the correlation between her age and complaint of pain to spine?
Pertambahan usia, fungsi organ tubuh menurun. Pada wanita usia 75 85
tahun, wanita memiliki risiko dua kali lipat dibandingkan pria dalam
mengalami kehilangan tulang trabekular karena proses penuaan, penyerapan
kalsium menurun, fungsi hormon paratiroid meningkat dan hormon estrogen
menurun
c. Mengapa sakit datang dan pergi?
d. mengapa dalam waktu 7 hari sakitnya berlanjut?
e. apa mekanisme pain dalam kasus ini ?
f. mengapa pain terjadi secara spontan tanpa sebab yang jelas?
Answer for all :
Fraktur adalah terputusnya kontinuitas jaringan tulang dan/atau tulang rawan.Fraktur juga berarti pemecahan suatu bagian terutama tulang atau kerusakan pada
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tulang. Fraktur yang terjadi biasanya di daerah vervical dan lumbal, tempat yang
mungkin dilakukan tarikan maximal dari columna vertebralis. Di daerah cervical,
dengan leher yang lurus, sebuah gaya vertikal yang berlebihan dari atas dapat
menyebabkan arcus atlantis cedera dan massa lateralis atlantis terdorong ke lateral
(fraktur Jefferson). Jika leher sedikit fleksio, vertebra cervicalis bagian bawah
tetap berada dalam garis lurus dan beban kompresi diteruskan ke vertebra yang
lebih bawah, tetapi tidak menyebabkan cedera discus invertebralis dan pecahnya
corpus vertebrae. Fraktur kompresi tanpa cedera atau fraktur patologis terjadi pada
kasus osteoporosis. Ketika terjadi fraktur tersebut sakit bisa datang dan pergi
secara spontan tanpa sebab yang jelas dikarenakan bentuk fraktur kompresi yang
pada tulang spongiosa dan garis patah fraktur lebih dari satu yang saling
berhubungan, fraktur kominutif. Terjadi juga fraktur undisplaced (tidak bergeser)
yang menyebabkan garis patah komplit tetapi kedua fragmen tidak bergeser,
periosteumnya masih utuh yang menyebabkan rasa sakit yang semakin menjadi
selama tujuh hari.
2. a. Apakah normal menopause saat berumur 50 tahun?
b. Apa hubungan menopause dengan sakitnya?
c. Apa hubungan tidak menikah dengan sakitnya?
d. Apakah orang yang menikah mempunyai kesempatan lebih besar terkena
menopause daripada yang tidak menikah?
3. a. Apa hubungan antara konsumsi lebih kopi dan merokok dengan
sakit yang dirasakannya?
b. Hormon apa yang terganggu pada konsumsi kopi dan merokok?
c. Kandungan apa saja yang ada di kopi dan merokok yang menyebabkan sakit
yang dirasakannya?
d. Cara kerja dari kopi dan merokok yang menyebabkan sakit yang dirasakan?
Answer for all :
1. Merokok
Rokok bisa meningkatkan risiko penyakit osteoporosis. Perokok sangat
mudah terkena osteoporosis, karena zat nikotin dan TAR di dalamnya
mempercepat penyerapan sel tulang. Selain penyerapan tulang, nikotinjuga membuat kadar dan aktivitas hormon estrogen dalam tubuh berkurang
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sehingga susunan susunan sel tulang tidak kuat dalam menghadapi
proses pelapukan. Rokok juga membuat penghisapnya bisa mengalami
hipertensi, penyakit jantung, dan tersumbatnya aliran darah ke seluruh
tubuh. Kalau darah sudah tersumbat, maka proses pembentukan tulang
sulit terjadi.
2. Minum kopi
Unsur utama dalam kopi adalah kafein konsumsi kafein berlebih
berkontribusi pada meningkatnya kehilangan kalsium dari tubuh. Asupan
kafein lebih dari 2 cangkir sehari seumur hidup berhubungan dengan
rendahnya densitas (kepadatan) massa tulang wanita usia lanjut. Dampak
negatif kafein pada masa tulang lebih besar pada wanita yang tidak minum
susu. Wanita yang berisiko tinggi terhadap osteoporosis dan kurang asupan
kalsium perlu membatasi kafein.
4. a. Apa interpretasi dari physical examination and radiologic
examination?
b. apa working diagnosis, diagnosis, prognosis, complication, management and
risk factor dari hasil physical examination and radiologic examination?
c. apa mekanisme pain yang dirasakan?
d. apa penyebab keropos dan physiology tulang?
e. hormon yang berpengaruh?
f. bagaimana nutrisi dan metabolismenya?
g. bagaimana prevention di semua usia?
h. bagaimana sistem neuromuscularskeletal?
IV. Hypothesis
Mrs. Fatimah, 70 years old, came with complaint of pain to spine 7 days due to
osteoporosis
V. Learning Issue
a. Lumbosakral and compression fracture
b. Osteoporosisc. Hormon and nutrition
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VI. Synthesis
1. Lumbosakral and compression fracture
The human spinal cord is divided into 31 different segments. At every segment, right and
left pairs of spinal nerves (mixed; sensory and motor) form. 68 motor nerve rootlets
branch out of right and left ventro lateral sulci in a very orderly manner. Nerve rootlets
combine to form nerve roots. Likewise sensory nerve rootlets form off right and left
dorsal lateral sulci and form sensory nerve roots. The ventral (motor) and dorsal (sensory)
roots combine to form spinal nerves(mixed; motor and sensory), one on each side of the
spinal cord. Spinal nerves, with the exception of C1 and C2 form inside intervertebral
foramen (IVF). Note that at each spinal segment the border between the central and
peripheral nervous system can be observed. Rootlets are a part of the peripheral nervous
system.
There are 31 (Some EMS text say 26, counting the sacral as one solid piece) spinal cord
nerve segments in a human spinal cord:
8 cervical segments forming 8 pairs of cervical nerves (C1 spinal nerves exit spinal
column between occiput and C1 vertebra; C2 nerves exit between posterior arch of C1
vertebra and lamina of C2 vertebra; C3-C8 spinal nerves through IVF above
corresponding cervica vertebra, with the exception of C8 pair which exit via IVF
between C7 and T1 vertebra)
12 thoracic segments forming 12 pairs ofthoracic nerves (exit spinal column through
IVF below corresponding vertebra T1-T12)
5 lumbar segments forming 5 pairs of lumbar nerves (exit spinal column through IVF,
below corresponding vertebra L1-L5)
5 (or 1) sacral segments forming 5 pairs of sacral nerves (exit spinal column through
IVF, below corresponding vertebra S1-S5)
1 coccygeal segment forming 1 pair ofcoccygeal nerves (exit spinal column through
the sacral hiatus)
http://en.wikipedia.org/wiki/Spinal_nervehttp://en.wikipedia.org/wiki/Cervical_nerveshttp://en.wikipedia.org/wiki/Thoracic_nerveshttp://en.wikipedia.org/wiki/Lumbar_nerveshttp://en.wikipedia.org/wiki/Sacral_nerveshttp://en.wikipedia.org/wiki/Coccygeal_nerveshttp://en.wikipedia.org/wiki/Spinal_nervehttp://en.wikipedia.org/wiki/Cervical_nerveshttp://en.wikipedia.org/wiki/Thoracic_nerveshttp://en.wikipedia.org/wiki/Lumbar_nerveshttp://en.wikipedia.org/wiki/Sacral_nerveshttp://en.wikipedia.org/wiki/Coccygeal_nerves7/27/2019 Tutorial 1 Blok 8
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Because the vertebral column grows longer than the spinal cord, spinal cord segments do
not correspond to vertebral segments in adults, especially in the lower spinal cord. In the
fetus, vertebral segments do correspond with spinal cord segments. In the adult, however,
the spinal cord ends around the L1/L2 vertebral level, forming a structure known as the
conus medullaris. For example, lumbar and sacral spinal cord segments are found
between vertebral levels T9 and L2.
Although the spinal cord cell bodies end around the L1/L2 vertebral level, the spinal
nerves for each segment exit at the level of the corresponding vertebra. For the nerves of
the lower spinal cord, this means that they exit the vertebral column much lower (more
caudally) than their roots. As these nerves travel from their respective roots to their point
of exit from the vertebral column, the nerves of the lower spinal segments form a bundle
called the cauda equina.
There are two regions where the spinal cord enlarges:
Cervical enlargement - corresponds roughly to the brachial plexus nerves, which
innervate the upper limb. It includes spinal cord segments from about C4 to T1. The
vertebral levels of the enlargement are roughly the same (C4 to T1).
Lumbosacral enlargement - corresponds to the lumbosacral plexus nerves, which
innervate the lower limb. It comprises the spinal cord segments from L2 to S3, and is
found about the vertebral levels of T9 to T12.
http://en.wikipedia.org/wiki/Vertebrahttp://en.wikipedia.org/wiki/Conus_medullarishttp://en.wikipedia.org/wiki/Cauda_equinahttp://en.wikipedia.org/wiki/Cervical_enlargementhttp://en.wikipedia.org/wiki/Brachial_plexushttp://en.wikipedia.org/wiki/Upper_limbhttp://en.wikipedia.org/wiki/Lumbosacral_enlargementhttp://en.wikipedia.org/wiki/Lumbosacral_plexushttp://en.wikipedia.org/wiki/Lower_limbhttp://en.wikipedia.org/wiki/Vertebrahttp://en.wikipedia.org/wiki/Conus_medullarishttp://en.wikipedia.org/wiki/Cauda_equinahttp://en.wikipedia.org/wiki/Cervical_enlargementhttp://en.wikipedia.org/wiki/Brachial_plexushttp://en.wikipedia.org/wiki/Upper_limbhttp://en.wikipedia.org/wiki/Lumbosacral_enlargementhttp://en.wikipedia.org/wiki/Lumbosacral_plexushttp://en.wikipedia.org/wiki/Lower_limb7/27/2019 Tutorial 1 Blok 8
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Vertebral Fractures :
An accurate assessment of the incidence of vertebral fracture is difficult as most patients
do not necessarily get admitted to hospital and the criteria for diagnosis are not clearly
defined. It is generally believed that only about a third of all vertebral deformities noted
on x-rays come to medical attention, and less than 10% necessitate admission to hospital.
The data from the United States and Europe, in women over the age 60 years demonstrate
a two to three fold greater incidence of vertebral fracture than men. The lifetime risk of aclinically diagnosed vertebral fracture is about 16% in white women compared with just
5% in white men. A recent study on the Chinese population suggest the risk of vertebral
fracture among post menopausal women in Beijing is about 25% lower than that noted in
Minnesota even though incidence of hip fractures in China is just one eighth of that in
women from Minnesota.
As anticipated the cause of fractures in the vertebra are much less related to falls and it is
estimated that only a quarter of such vertebral fractures result from falls and most are
precipitated by routine everyday activities of daily living21. The likelihood of fracture of
a vertebra depends on the compressive strength of a vertebral body and is partly
determined by the bone density and each standard deviation drop is associated with twice
the risk of fracture. It is also believed that occurrence of one vertebral fracture, even in
asymptomatic individuals detected incidentally on a routine radiograph increases the
likelihood of additional fracture by at least fourfold. This increased risk is apparently not
dependent on bone density, which suggests the quality of the bone may be more
important in the pathogenesis of these fractures in the vertebra rather than the bone
density alone.
Lumbar Vertebrae
The spine is made up of three groups of bones called "vertebrae." There are five "lumbar
vertebrae" in the small of the back (loins). Since the lumbars must support more weight
than the vertebrae above them, they have developed larger and stronger bodies. The
transverse processes of these vertebrae project backward at sharp angles, while theirshort, thick spinous processes are directed nearly horizontally.
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Lumbar SpineFracture of the lumbar spine can occur whenever forces applied to the lower spinal
column exceed the strength and stability of the spinal column unit. Common injuries
resulting in fractures of the lumbar spine include fall from a height; motor vehicle and
motor vehicle and pedestrian accidents; and penetrating trauma, including gunshot
wounds and stabbings. Unstable injuries to the pelvis often are associated with injury to
the sacral plexus and the lower lumbar spine.
The spine is one of the strongest and of the most important parts of the body. Every
organ relies on the support of the spine like the chassis of a car. The wellness of the body
is based on the right posture of the spine and alignment of the spine, since eighty-five
percent all of symptoms are due to spinal blockages. The spine consists of seven cervical,
twelve vertebra, five lower lumbers, five sacral, and four coxies including the tailbone.
Each and every joint of the spine represents a different organ. For instance if any nerves
or veins due to wrong posture is blocked in vertebrae four. You will have problems with
your speech. In the same way if vertebrae one through four and five have blockages, it
will affect your lower back, you will suffer from tremendous back pain, noticing
difficulty in walking and sitting due to the pain. The spinal cord is lubricated with the
cerebral fluid starting from the lower lumber to cervical. This natural lubricant must be
flowing without obstruction to enable the spine functioning properly. Seventy-three
nerves are parallel to the spine, which assists, in the proper circulation to all the parts of
the body. It is imperative that the nerves are free of blockages and plaque since they
carry the required minerals and vitamins to every system of the body. Wherever the
nerves are blocked, for example, your lower back hurts then your lower back it is not
receiving the proper circulation resulting in the minerals and vitamins unable to nourish
your lower back. The chemistry of the body is changed, symptoms and disease occur until
the nerves are unblocked.
Sacrum
The sacrum is a large triangular bone at the base of the lower spine. Its broad upper part
joins the lowest lumbar vertebrae and its narrow lower part joins the coccyx or "tail
bone". The sides are connected to the iliums (the largest bones forming the pelvis). The
sacrum is a strong bone and rarely fractures. The five vertebrae that make up the sacrum
are separated in early life, but gradually become fused together between the eighteenth
and thirtieth years. The spinous processes of these fused bones are represented by a ridge
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of tubercles. The sacrum is wedged between the coxal bones of the pelvis and is united to
them by fibrocartilage at the sacroiliac joints. The weight of the body is transmitted to the
legs through the pelvic girdle at these joints.
What are the symptoms of a compression fracture of the spine?
Back pain is by far the most common problem in patients with a compression fracture.
Patients with osteoporosis who sustain multiple compression fractures may begin to
notice a curving of the spine, like a hunchback, called a kyphotic deformity. The reason
for this is the vertebrae are compressed in front, and usually normal in back. This wedge
shaped appearance causes the spine to curve forward. When enough compression occurs,
this may become a noticeable curvature. Patients with compression fractures also often
notice a loss of their overall height because of the decreased size of the spinal column.
Nerve complaints are unusual in compression fractures because the spine and its nerves
are behind the vertebra, and, as mentioned above, the front of the vertebra is compressed
and the back remains normal. In some serious traumatic fractures, called "burst fractures,"
the compression occurs around the spinal cord and nerves. This is more serious and may
require immediate treatment to prevent or relieve pressure on the spinal cord or nerves.
2. Osteoporosis
What is osteoporosis?
Osteoporosis means porous bones. It is a condition where the skeleton becomes fragile
and results in broken bones under normal use. Osteoporosis is a silent condition that
happens slowly over years. The rate of bone loss resorption exceeds the rate of new
bone formation acretion. Many times neither a person nor a doctor is aware of
weakened bones until one breaks unexpectedly.
What are the symptoms of osteoporosis?
Because of mineral loss, osteoporosis can cause progressive breaks in a persons back.
This causes a person to lose height and get shorter and shorter. This spinal compression
causes a gradual decrease in height due to forward bending of the upper spine. This
eventually results in a painful, stooped back, commonly referred to as a dowagers
hump. And, loss of height can also result in a pot belly or a prominent abdomen even
with no increase in weight.
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What happens to bones with osteoporosis?
Most people think of their bones as completely solid and unchanging. This is not true.
Your bones are constantly changing as they respond to the way you use your body. As
muscles get stronger, the bones underneath them get stronger, too. As muscles lose
strength, the bones underneath them weaken. Changes in hormone levels or the immune
system can also change the way the bones degenerate and rebuild themselves.
As a child, your bones are constantly growing and getting denser. At about age 25, you
hit your peak bone mass. As an adult, you can help maintain this peak bone mass by
staying active and eating a diet with enough calories, calcium, and vitamin D. But
maintaining this bone mass gets more difficult as we get older. Age makes building bone
mass more difficult. In women, the loss of estrogen at menopause can cause the bones to
lose density very rapidly.
The bone cells responsible for building new bone are called osteoblasts. Stimulating the
creation of osteoblasts helps your body build bone and improve bone density. The bone
cells involved in degeneration of the bones are called osteoclasts. Interfering with the
action of the osteoclasts can slow down bone loss.
In high-turnover osteoporosis, the osteoclasts reabsorb bone cells very quickly. The
osteoblasts cant produce bone cells fast enough to keep up with the osteoclasts. The
result is a loss of bone mass, particularly trabecular bone--the spongy bone inside
vertebral bones and at the end of long bones. Postmenopausal women tend to have
highturnover osteoporosis (also known asprimarytype one osteoporosis). This relates to
their sudden decrease in production of estrogen after menopause. Bones weakened by this
type of osteoporosis are most prone to spine and wrist fractures.
In low-turnover osteoporosis, osteoclasts are working at their normal rate, but the
osteoblasts arent forming enough new bone. Aging adults tend to have low-turnover
osteoporosis (also known as primary type two osteoporosis). Hip fractures are most
common in people with this type of osteoporosis. Secondary osteoporosis describes bone
loss that is caused by, orsecondary to, another medical problem. These other problems
interfere with cell function of osteoblasts and from overactivity of osteoclasts. Examples
include medical conditions that cause inactivity, imbalances in hormones, and certain
bone diseases and cancers. Some medications, especially long term use of corticosteroids,
are known to cause secondary osteoporosis due to their impact on bone turnover.
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Osteoporosis creates weak bones. When these weak bones are stressed or injured, they
often fracture. Fractures most often occur in the hip or the bones of the spine (the
vertebrae). They can also occur in the upper arm, wrist, knee, and ankle.
What is characteristic of osteoporosis?
Tipe 1 Tipe 2Umur 50 75 >70 : 6 : 1 2 : 1
kerusakan tulang Terutama trabekular Trabekular dan kortikelBone turnover Tinggi rendahLokasi fraktur Vertebra, radius distal Vertebral, kolum femoris
Fungsi paratiroid Menurun meningkatFungsi estrogen Terutama skeletal Terutama ekstraskletalEtiologi utama Defisiensi estrogen Penuaan, defisien estrogen
Patogenesis osteoporosis tipe 1
Setelah menopause, maka reabsorpsi tulang akan meningkat, terutama pada dekade awal
setelah menopause sehingga insiden fraktur, terutama fraktur vertebra dan radius distal
meningkat. Penuaan densitas tulang terutama pada tulang trabekular, karena memiliki
permuakaan yang luas dan hal ini dapat dicegah dengan terapi sulih estrogen. Petanda
resorpsi tulang dan fromasi tulang keduanya meningkat menunjukkan ada bone turnover.
Estrogen juga berperan menurunkan produksi berbagai sitokin oleh bone marrow stromal
cell dan sel - sel mononuklear, seperti IL-1, IL-6, dan TNF yang berperan
meningkatkan kerja osteoklas. Dengan demikian penurunan kadar estrogen akibat
menopause akan meningkatkan produksi berbagai sitokin tersebut sehingga aktivitas
osteoklas meningkat.
Menopause
Estrogen
Bone marrowstromal cell + sel
mononuklear
Reabsorpsikalsium
osteoklasSel endotelosteoblas Reabsorpsidi ginjal
HIL-1,TNF , IL-6, M-CSF
TGF NO Hipokalsema
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reabsorpsi tulang
osteoporosis
Patogenesis osteoporosis tipe 2
Selama hidupnya seorang wanita akan kehilangan tulang spinalnya sebesar 42 % dan
kehilangan tulang femurnya sebesar 58 %. Pada dekade kedelapan dan sembilan
kehidupannya, terjadi ketidakseimbangan remodeling tulang, dimana resorpsi tulang
meningkat, sedangkan formasi tulang tidak berubah atau menurun. Hal ini akan
menyebabkan kehilangan massa tulang, perubahan mikroarsitektur tulang dan
peningkatan risiko fraktur. Peningkatan resorpsi tulang merupakan risiko fraktur yang
independen terhadap BMD. Peningkatan osteokalsin seringkali didapatkan pada orang
tua, tetapi hal ini lebih menunjukkan peningkatan turnover tulang dan bukan peningkatan
formasi tulang.
Defisiensi kalsium dan vitamin D sering didapatkan pada orang tua. Hal ini disebabkan
oleh asupan kalsium dan vitamin D yang kurang, anoreksia, malabsorpsi dan paparan
sinar matahari yang rendah. Aspek nutrisi yang lain adalah defisiensi protein yang akan
menyebabkan penurunan sintesis IGF-1. Defisiensi vitamin K juga akan menyebabkan
osteoporosis karenan akan meningkatkan karboksilasi protein tulang, misalnya
osteokalsin. Defisiensi estrogen adalah salah satu penyebab osteoporosis. Pada laki laki
estrogen berfungsi mengatur resorpsi tulang, sedangkan estrogen dan progesteron
mengatur formasi tulang. Kehilangan massa tulang trabekular pada laki laki
berlangsung linier, sehingga terjadi penipisan trabekula tanpa disertai putusnya trabekula
seperti pada wanita. Putusnya trabekula pada wanita disebabkan karenan peningkatan
resorpsi yang berlebihan akibat penurunan kadar estrogen yang drastis ketika menopause.
Faktor lain yang juga ikut berperan pada kehilangan massa tulang pada orang tua adalah
faktor genetik dan lingkungan (merokok, alkohol, obat obatan, imobilisasi lama).
Dengan bertambahnya umur, remodelling endokortikal dan intrakortikal akan meningkat,sehingga kehilangan tulang terutama terjadi pada tulang kortikal dan meningkatkan risiko
diferensiasi dari muturasi osteoklas
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fraktor tulang kortikal, misalnya pada femur proksimal. Total permukaan tulang untuk
remodelling tidak berubah dengan bertambahnya umur, hanya berpindah dari tulang
trabekular ke tulang kortikal. Risiko fraktur karena terjatuh juga harus diperhatikan.
What are the risk factors for osteoporosis you cant control?
Unchangeable risk factors are:
gender: being female; women are five times more likely to develop osteoporosis than
men.
lack of exercise: bedridden people lose bone faster than people who exercise regularly
having a thin, small-boned frame
family history of older family members with broken bones or stooped posture,
especially women, which suggests osteoporosis
history of disordered eating that may have contributed to a loss of regular menstrual
cycles
an early menopause in women before age 45 due to estrogen deficiency, either naturally
or resulting from surgical removal of the ovaries and not treated with hormone
replacement therapy
race: Caucasian and Asian women are at highest risk while African and Hispanic
women are at lower risk
Defisiensi vitamin D, aktifitas 1-
hidroksilase, resistensiterhadap vitamin D
Usia lanjut
absorpsiCa di usus
sekresi GH
dan IGF 1
aktifitas
fisik
sekresi
estrogen
reabsorpsiCa di ginjal
Hiperparatiroidosme
sekunder
osteoporosis
Fraktur terjatuh
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prolonged use of some medications such as glucocorticoids (prednisone) used as an anti-
inflammatory to treat asthma or arthritis, excessive thyroid hormone, and some anti-
seizure medications; and antacids that contain aluminum
age: the risk of osteoporosis increases with age low testosterone level (in men) not
treated with hormone therapy
Those listed above are risk factors you cant control. Are there other risk factors that you
can control?
Yes, you can control these risk factors with lifestyle changes. Here are some suggestions:
get foods that are rich in calcium and vitamin D
dont smoke or quit smoking
if you drink alcohol, do so in moderation
get regular weight bearing and resistance exercise
avoid excess protein intake
avoid extreme dieting that can lead to loss of regular mestrual cycles
avoid excessive soda pop intake which contains phosphoric acid
How is osteoporosis diagnosed?
Dual energy X-ray absorptiometry (DXA, previously DEXA) is a means of measuring
bone mineral density(BMD). TwoX-ray beams with differing energy levels are aimed at
the patient's bones. When soft tissue absorption is subtracted out, the BMD can be
determined from the absorption of each beam by bone. Dual energy X-ray absorptiometry
is the most widely used and most thoroughly studied bone density measurement
technology.
A T-scoreequal to or less than -2.5 is indicative ofosteoporosis. This test is very reliable.
Special considerations are involved in the use of DXA to assess bone mass in children.
Specifically, comparing the bone mineral density of children to the reference data of
adults (to calculate a T-score) will underestimate the BMD of children, because children
have less bone mass than fully developed adults. This would lead to an over diagnosis of
osteopeniafor children. To avoid an overestimation of bone mineral deficits, BMD scores
are commonly compared to reference data for the same gender and age (by calculating a
Z-score).
Also, there are other variables in addition to age which are suggested to confound the
interpretation of BMD as measured by DXA. One important confounding variable is bone
size. DXA has been shown to overestimate the bone mineral density of taller subjects andunderestimate the bone mineral density of smaller subjects. This error is due to the way in
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which DXA calculates BMD. In DXA, bone mineral content (measured as the attenuation
of the X-ray by the bones being scanned) is divided by the area (also measured by the
machine) of the site being scanned.
Because DXA calculates BMD using area (aBMD: areal Bone Mineral Density), it is not
an accurate measurement of true bone mineral density, which is mass divided by a
volume. In order to distinguish DXA BMD from volumetric bone-mineral density,
researchers sometimes refer to DXA BMD as an areal bone mineral density (aBMD). The
confounding effect of differences in bone size is due to the missing depth value in the
calculation of bone mineral density. Despite DXA technology's problems with estimating
volume, it is still a fairly accurate measure of bone mineral content. Methods to correct
for this shortcoming include the calculation of a volume which is approximated from the
projected area measure by DXA. DXA BMD results adjusted in this manner, are referred
to as the bone mineral apparent density (BMAD) and are a ratio of the bone mineral
content versus acuboidal estimation of the volume of bone. Like aBMD, BMAD results
do not accurately represent true bone mineral density, since they use approximations of
the bone's volume. BMAD is used primarily for research purposes and is not yet used in
clinical settings.
Other imaging technologies such as Computed Quantitative Computer Tomography
(QCT) are capable of measuring the bone's volume, and are therefore not susceptible to
the confounding effect of bone-size in the way that DXA results are susceptible. DXA
uses X-rays to assess bone mineral density. However, the radiation dose is approximately
1/10th that of a standard chest X-ray
What can you do to prevent osteoporosis?
Osteoporosis cant be prevented outright. However, the onset of this condition can be
delayed and the severity reduced. Calcium intake is critical in childhood as well as young
adulthood. Calcium cant build bone by itself; vitamin D is also required. And a lifelong
habit of weightbearing exercise such as walking or resistance exercise, also helps build
and maintain strong bones.
Is there a cure for osteoporosis?
There is no cure for osteoporosis. However, the onset of this condition can be delayed.
And, early intervention can prevent bone fractures.
What kinds of treatments are available for a person with osteoporosis?
Drug treatments?
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For many years, the only choices for drug treatment of osteoporosis were the hormones
estrogen and calcitonin. Estrogen replacement therapy (ERT) is the best prevention for
the drop in bone mass at menopause. Estrogen not only helps prevent osteoporosis, but
also protects against heart disease. However, some 3050% of women are concerned
about taking estrogen. These women may have risk factors which make them more likely
to get cancer if they take estrogen. They now have other treatment options.
A non-hormonal treatment, Alendronate marketed as Fosamax, slows down bone
breakdown by inhibiting osteoclast activity. Its been shown to increase bone mass as
much as 8% and reduce fractures by 30-40%. Studies are still ongoing to determine its
effectiveness and side effects.
Non-drug treatments or supplements?
Calcium and vitamin D supplements are an integral part of all treatments for osteoporosis.
Calcium carbonate supplements are best (e.g., Oscal, Caltrate, Tums) absorbed in doses
of 500 milligrams or less taken with meals. Calcium citrate (e.g., Citrical) can be taken
between meals. In addition, diet and exercise are important not only for treatment but for
prevention.
What foods can I eat to prevent osteoporosis?
Bone health requires a lot of nutrients and youre likely to get most of them in dairy
products. For those concerned with lowering the fat in their diet, low fat and nonfat dairy
products are still excellent sources of calcium and vitamin D. The best recommendation
for overall good health includes a balanced and varied diet with foods adequate in
calcium, protein, vitamins and minerals, and eating in moderation.
Other ways to get CALCIUM into your diet especially if you dont consume dairy
productsis to eat foods fortified with calcium, such as orange juice, or take calcium
supplements.
Other good sources of calcium are:
broccoli
dark-green leafy vegetables like kale
tofu, calcium fortified
canned fish with bones
fortified bread and cereal products
How much calcium do I need each day?
The recommended dietary reference intakes from the National Academy of Sciences foradults is 1,000 to 1,300 milligrams a day with hormone replacement and 1500 mg a day
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without hormone replacement. The recommendation is aimed at decreasing the risk of
chronic disease through nutrition. The National Osteoporosis Foundation recommends
1,500 milligrams a day for men over 65 (as well as for women over age 50)-the amount in
five glasses of milk. In addition for healthy bone, adults need 400 international units (IUs)
of vitamin D daily, the amount in 1 quart of milk or 10 minutes of sun exposure,
weightbearing exercise, and good lifestyle habits. (Too much vitamin D can result in
vitamin D toxicity and can cause health problems so more vitamin D is NOT better).
Clinical Diagnosis and Management :
Osteoporosis is undetectable until the onset of fractures just as hypertension may remain
undetected until a serious consequence of untreated hypertension occurs. Both
hypertension and Osteoporosis are asymptomatic, but, if left untreated and undetected
they can lead to their respective clinical consequences. Therefore detection of the disease
is paramount before the consequences manifest clinically.
Increased bone resorption
Loss of bone mass poor bone quality trauma
Progressive increase in fracture risk
DD Nyeri Fraktur Penyebab KeteranganOsteoporosis Nyeri pada
punggung / tulang
belakang
Kadang nyeri
radiculopathic
Biasa terjadi pada
vertebral column,
hip and wrist
Beresiko terjadi
fraktur karena
berkurangnya
kepadatan tulang,
spinal cord
compression atau
cauda equina
syndrome
Berkurangnya
kepadatan tulang
Menopause
Penyakit
degeneratif
Tidak ada
symptom yang
spesifik
Osteomalasia Tidak ada nyeri,
hanya
ketidakmampuan
tulang yang parah
Dapat terjadi
fraktur bila ada
riwayat injury
Defisiensi
vitamin D
Defisiensi sinar
matahari
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Osteoarthritis Nyeri pada otot dan
tendon (tangan, kaki,
spine dan paha)
Tidak ada fraktur
tulang kecuali
jika pernah
mengalami injury
Penyakit
degenerative,
alergi, infeksi,
fungi
Biasanya
menyerang pada
orang gemuk,
tidak
berhubungan
dengan usia tua,
ada spur /
osteophytes
3. Hormone and nutrition
1. Calcium and Vitamin D
Calcium and Vitamin D intake modulates age related increases in parathyroid hormone
(PTH) levels and bone resorption. Adequate intake of Calcium have been proven to be
useful in randomised clinical trials and such supplements in diet increases the Bone
Mineral Density of spine and reduce the vertebral and non vertebral fractures. Low levels
of 25 hydroxy Vitamin D are quite common in the ageing population and significant
reduction in hip and other non vertebral fractures have been observed in patients
receiving this therapy in prospective clinical trials. The maximum effective dose of
Vitamin D is uncertain but thought to be around 400 1000 IU per day. There is
consensus about the fact that Vitamin D. Supplements in adequate amounts together with
Calcium intake are required for good bone health. The therapeutic effects of most of the
clinical trials of various drug therapies for Osteoporosis have been achieved in the
presence of Calcium and Vitamin D supplementation among the control of our patients in
the interventional studies.
Optimal treatment of Osteoporosis with any drug therapy also requires Calcium and
Vitamin D intake meeting recommended levels. The preferred source of Calcium is
dietary and Calcium supplements should be available in an absorbable state. A few
epidemiological studies have shown that treatment with Vitamin D was associated with a
reduction of Hip fracture by 55 % amongst elderly women with low Body Mass Index.
Indeed, parental vitamin D may be worthwhile particularly in patients in the developing
world where a lot of social bias exists about Hormone replacement therapy and also some
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newer drugs. It will have also a significant effect on the savings to health service as well
as personal expenses, which is usually the case in the so-called Developing world.
2. Bisphosphonates
Systematic review and metanalysis of various randomised placebo controlled clinical
trialson Bisphosphonates have revealed that all of these Bisphosphonates increase bone
density at the spine and hip in a dose dependent manner. They consistently reduce the risk
of vertebral fractures by about 30 50%. Alendronate and Risedronate reduce the risk of
subsequent non-vertebral fractures in women with Osteoporosis and adults
glucocorticoid induced
Osteoporosis. There is uncertainty about the effect of anti resoptive therapy in reducing
non-vertebral fracture in women without Osteoporosis. In randomised clinical trials the
relative risk of discontinuing medication due to an adverse event with each of the three
Bisphosphonates was not very statistically significant. The safety and efficacy of this
therapy in children and young adults has not been evaluated as subjects in clinical trials
may not always be representative and reflective of the real clinical practice. The recent
data of the effect of Risedronate is very promising with the improvement in bone density
occurring within six months at all sites.
3. Hormone Replacement Therapy (HRT)
This is an established treatment for Osteoporosis in postmenopausal women particularly
in those who have significant postmenopausal symptoms. It is essentially an approach to
both prevention and treatment and many short term studies and some long term studies
with Bone Mineral Density has a primary outcome have in fact shown its efficacy.
Observational studies also had demonstrated reduction in hip fracture in cohorts of
women who maintain HRT therapy and it has also been shown to reduce the vertebral
fracture risk although there is some posity of studies on the prevention of hip fracture by
Oestrogen. The development of selective Oestrogen receptor modulators (SERM) has
been an important new thrust in Osteoporosis research projects and the goal of these
agents is to maximise the beneficial effect of Oestrogen on bone and to minimise or
antagonise the deleterious effects on the breasts and endometrium. Raloxifene, a SERM
product for the treatment and prevention of Osteoporosis has been shown to reduce the
risk of vertebral fracture by 30 40% in large prospective clinical trials. Tamoxifen, often
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used in the treatment and prevention of breast cancer, can maintain bone mass in
postmenopausal women. However, its effects on fracture rates are yet unclear.
4. Natural Oestrogens
There is a great deal of public interest in natural Oestrogens, particularly plant derived
Phyto-Oestrogens. These compounds have weak Oestrogen like effects and although
some animal studies are promising, no effects on fracture reduction in humans have yet
been shown.
5. Calcitonin
Salmon Calcitonin has demonstrated positive effects on Bone Mineral Density at the
lumbar spine, but this effect is less clear at the hip. Other than a recently completed
randomised controlled trial of nasal Calcitonin, no analysis of fracture risk is yet
available. The PROOF study revealed a significant reduction in vertebral fracture risk at
the 200 IU dose but not at the 100 IU or 400 IU dose.
The absence of dose response and the lack of strongsupporting data from Bone Mineral
Density and markers decrease confidence in the fracture risk data from this trial. Data on
the effects of Calcitonin on fracture rates have been summarised in a recent published
systematic reviewin which 14 randomised trials, including 1309 men and women, were
identified and all but one of these studies used symphetic Salmon Calcitonin and the root
of administration varied. The relative risk of any fracture for individuals taking
Calcitonin, when compared to those not taking the drug, was 0.43 (95% CI.0.38-0.50).
The effect was apparent for both vertebral fracture (relative risk equal to 0.45; 95% CI
0.39 0.53) and non-vertebral fractures (relative risk equal to 0.34; 95% CI 0.17 0.68).
When same studies were analysed identifying patients with fracture rather than numbers
of fractures the magnitude of effect was somewhat less (relative risk equal to 0.74; 95%
CI 0.60 0.93), and the separate effects on vertebral and non vertebral fractures became
non significant. This data suggests that Calcitonin treatment was associated with a
significant decrease in the number of vertebral and non vertebral fractures but that dose
benefits might be lower than those observed in the trials of Bisphosphonates
6. Parathyroid Hormones
Most conventional agents described so far, in our experience, has shown that the bonedensity increases year after year for the first two three years and thereafter it tends to
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plateaus. Although anti resorptive agents do reduce the fracture by about 40-60 % in
spine compared to placebos, they never normalise the bone density. It is possible that in
these scenarios an additional agent such as Parathyroid hormone (PTH) act as an anabolic
agent. PTH exerts most of its effects on bone through the PTH 1 receptor, which it shares
with the PTH receptor protein (PTH r P). These receptors are absent on Osteoclasts but
are abundantly present in the stromal cells of the Osteoblastic lineage. Increased
Osteoclastic resorption, driven by PTH, is believed to be a consequence of secondary
signalling from bone cells. Further activation of the PTH receptors is likely to include
recruitment to the osteoblastic phenotype, prevention of apoptosis of osteoblasts besides
augmentation of the capacity of the osteoblasts to form new bone. In clinical trials, it is
possible to synthesise the whole PTH molecule by recombinant technology, only active
fragments of PTH, made (like calcitonin) by solid state technology, were available when
the human studies began. Initial studies with human PTH (1-34) were undertaken for two
simple reasons i.e. it was thought to be a natural cleavage product and secondly it all
retained all the bioactivity of natural PTH in the chich hypercalcemia assay. Very recently
human PTH (1-36 & 1-38) has been found which may well have a greater potency than
the h PTH (1-34). PTH has been studied and found active in Postmenopausal
osteoporosis, Glucocorticoid induced osteoporosis and Idiopathic Osteoporosis of men
and GnRh induced Osteoporosis.
7. Testosterone and Anabolic Steroids
As early as 1941, Albright first reported the efficacy of androgens in the treatment of
osteoporosis. Several anabolic steroids have been tried in humans including Stanozolol
and Nandrolone; the former given by mouth and the latter given by intra muscular
injection .The effects of these steroids on bone mass are essentially consistent with a
preferential effect of these agents on the cortical bone mass. It is associated with an
increase in total body calcium and this increase can continue over years. We do not have
any major reservation for its used in the elderly men who have a number of fragility
fractures and are intolerant to more conventional drug regimens.
8. Teriparatide
Teriparatide (Forteo) is an injectable form of human parathyroid hormone. It is
approved for postmenopausal women and men with osteoporosis who are at high
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risk for having a fracture. Unlike the other drugs used in osteoporosis,
teriparatide acts by stimulating new bone formation. Side effects include nausea,
dizziness, and leg cramps. Teriparatide is approved for use for up to 24 months.
REFERENSI
www.nhlbi.nih.gov/health/public/heart/other/sp_smok
http://www.nhlbi.nih.gov/health/public/heart/other/sp_smokhttp://www.nhlbi.nih.gov/health/public/heart/other/sp_smok7/27/2019 Tutorial 1 Blok 8
24/24
Kamus Kedokteran Dorland. 2006. EGC : Jakarta.
Price, Sylvia A. and Wilson. 2006. Patofisiologi Konsep Klinis Proses-Proses Penyakit
Volume 1 dan 2. EGC : Jakarta.
Robbins, Cotrans, and Kumar. 1995.Buku Saku Dasar Patologi Penyakit. edisi 5. EGC :
Jakarta.
Staf pengajar IKA FK UI. 1985.Ilmu Penyakit Dalam. INFOMEDIKA : Jakarta
Harrison's Principles of Internal Medicine, McGraw-Hill, edited by Eugene Braunwald, et.
al., 2001.
F. Rauch. What is new in neuro-musculoskeletal interactions?.literature review
Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride.
Institute of Medicine, Food and Nutrition Board, National, Academy Press, 1997.
http://www.niams.nih.gov/Health_Info/bone/default.asp
Coffee and Calcium Loss. By Robert H. Shmerling, M.D., Harvard Medical School, for MSN
Health & Fitness
www.wikipedia/DXA
www.eOrthopod.com
Osteoporosis: Detection, Prevention and Treatment with Chiropractic Care.by Dr. Ailin
Oishi-Stamatiou. Literature review
www.bethanymedical.pdf/osteoporosis.com
http://www.google.com/http://www.niams.nih.gov/Health_Info/bone/default.asphttp://www.wikipedia/DXAhttp://www.google.com/http://www.niams.nih.gov/Health_Info/bone/default.asphttp://www.wikipedia/DXA