Turmeric for joint health There is more to Turmeric than just Curcuminoids! This presentation is meant for Business to Business communication. The information given here is not meant for consumers. Deepak Mundkinajeddu Natural Remedies Pvt Ltd Bangalore, India
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Turmeric for joint healthThere is more to Turmeric than just Curcuminoids!
This presentation is meant for Business to Business communication. The information given here is not meant for consumers.
Deepak MundkinajedduNatural Remedies Pvt LtdBangalore, India
My introduction
• Pharmacy background with a PhD in natural products • Key research interests
• Bioactivity profiling of medicinal plants• Bioassay guided fractionation and isolation of active constituents• Taking science from preclinical to clinical stage• Intellectual properties and regulatory aspects
• Collaborations• Pharmacopoeial bodies – USP, API /UPI, IP• Government bodies – NMPB, DST and DBT• Universities – Manipal (adjunct faculty), JSS
This presentation is meant for Business to Business communication. The information given here is not meant for consumers.
Contents of this presentation
• Use of Turmeric in India• Medicine and Food
• Turmeric - Market scenario• Unexplored gaps between tradition and market
• R&D - water soluble components of Turmeric for joint health• Turmerosaccharides as active constituents• Development of Turmacin® • Preclinical and clinical trials for efficacy and safety
• Application to current market needs• Supplements and foods
This presentation is meant for Business to Business communication. The information given here is not meant for consumers.
Turmeric comes from cultivated sources• The global production of turmeric is around
11 lakh MT per annum. India dominates the
world production scenario contributing 78 %
• Domestic demand. Livelihood of many
farmers.
• NGOs, companies…..
• Supply chains established
• Availability of organic gradesThis presentation is meant for Business to Business communication. The information given here is not meant for consumers.
Condition Healthy volunteers (exercise induced pain and discomfort)
Study design Randomized Double-blind placebo-controlled study
Dose 0.5 g and 1 g per day
Participants 90 (with 30 per group; Age: 18-65 years)
Duration 84 days
EvaluationPain using VAS on days 5, 7, 28, 56 & 84Mobility using digital goniometry on days 5, 28 and 84Muscle strength on day 84 using isokinetic dynamometry
Turmacin® supports joint health by maintaining equilibrium between degradation and synthesis of cartilage matrix
This presentation is meant for Business to Business communication. The information given here is not meant for consumers.Chandrasekaran et al. Inflammopharmacology (2018) https://doi.org/10.1007/s10787-017-0433-1
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Mode of action
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Joint with healthy cartilage Due to ageing/strenuous exercise
Cartilage cell death
Structural components - GAG & Type II
collagen
Cartilage damage
IL-1β
Inflammatory mediators
Turmacin®
Turmacin®More IL-1β is released
IL-1βInhibits
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Human safety study
Variable
Turmacin® 1g (n=27)
Placebo(n = 27)
p value
Mean ± SD Mean ± SD
AST 26.63 ± 25.99 18.11 ± 6.26 0.134
ALT 30.48 ± 19.54 30.63 ± 13.36 0.833
Glucose 89.33 ± 7.55 92.67 ± 7.65 0.255
Creatinine 0.81 ± 0.17 0.83 ± 0.17 0.206
Haemoglobin 14.45 ± 2.01 14.10 ± 2.01 0.806
No significant differences between groups and no clinically relevant changes in the
safety parameters after treatment with Turmacin ® at 1g for 84 days
Heartburn observed in 1 participant of Turmacin ® (1g)
and in 3 of 4 subjects of Placebo group
Turmacin® (1g) Turmacin® (2g)
Day 0 Day 42 Day 84
Incidence of adverse events Clinical laboratory parameters (including haematological, biochemical,
and urinalysis parameters), vital signs, electrocardiogram (ECG)
Haematological, biochemical, urinalysis, ECG , vitals normal in the treated volunteers.
Mild nausea (1) observed in Turmacin® (1g)
Mild abdominal pain (2), mild abdominal bloating (1), moderate GI upset (1) and mild nausea (1)
observed in Turmacin ® (2g)
Shots Sprays
Dose:0.5 to 1g per day
Novel formulations possible –
Scientific publications on Turmacin®
1. Madhu et al. Inflammopharmacology 2013, 21(2): 129-136
2. Illuri et al. Anti-inflammatory and Anti-allergy Agents in Medicinal Chemistry 2015, 14(1): 53-62
3. Senthilkumar et al. Journal of Korean Society Food Science and Nutrition 2014, 43(1): 612-617
4. Chandrasekaran et al. Pharmacognosy Research 2013, 5(2): 71-79
5. Chandrasekaran et al. BioMed Research International 2013, 2013: 158348, 10 pages
6. Bethapudi et al. Pharmacognosy Magazine 2017, 13(Suppl 3): S623-S627.
7. Velusami et al. Inflammopharmacology. 2018 Jan 8. doi: 10.1007/s10787-017-0433-1.
8. Sasikumar et al. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2017, 16, 193-202
This presentation is meant for Business to Business communication. The information given here is not meant for consumers. 28
Summary
• Concept of • There is more to turmeric than just curcuminoids -
Scientifically supported with a novel ingredient for joint health – Turmacin• Turmerosaccharides are the other bioactive constituents of Turmeric• The efficacy, safety and mechanisms of action supported with
• Human clinical studies• In vivo studies• In vitro studies
• Formulation ideas• Combination with curcuminoids • Food and beverages
This presentation is meant for Business to Business communication. The information given here is not meant for consumers.
30This presentation is meant for Business to Business communication. The information given here is not meant for consumers.
Thank You!
This presentation may contain statements and classification about the ingredient which may not be in line with the regulations of your country. The statement or claims made are in reference to ingredient only and therefore do not refer to the finished productdirectly or indirectly. The claims made on the finished product containing the ingredient are the sole responsibility of manufacturer or the marketer. We urge manufacturer and marketer to ensure that the claims made on the finished product comply with the lawand regulation of the country in which the product is to be sold.
The statements used in the presentation have not been evaluated by USFDA. This ingredient is not intended to diagnose, treat, cure or prevent any disease.