Translating the Neurobiology of Addiction Into New Treatments: Medication Assisted Recovery Barbara J. Mason, Ph.D. Pearson Family Professor, Committee on the Neurobiology of Addictive Disorders Co-Director, The Pearson Center for Alcoholism and Addiction Research SAB Malibu Beach Sept. 29 & 30, 2013
9
Embed
Translating the Neurobiology of Addiction Into New Treatments: Medication Assisted Recovery
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Translating the Neurobiology of Addiction Into New Treatments: Medication Assisted Recovery
Barbara J. Mason, Ph.D.Pearson Family Professor, Committee on the Neurobiology of Addictive Disorders
Co-Director, The Pearson Center for Alcoholism and Addiction Research
SAB Malibu BeachSept. 29 & 30, 2013
Source: SAMHSA National Survey on Drug Use and Health, 2010
Numbers in Thousands
Medication Targets in the Cycle of Alcoholism and Addiction
* From: http:www.evaluatepharma.com** Includes all indications
Nucleus Accumbens (Binge-intoxication) — Structure in the front bottom of the brain involved in the rewarding effects of drugs of abuse that is a key part of the binge/intoxication stage of addiction. Contains reward neurotransmitters dopamine and opioid peptides that are involved in the euphoric effects of addiction.
Extended Amygdala (Withdrawal-negative affect) — A set of structures in the front middle of the brain that include the central nucleus of the amygdala, bed nucleus of the stria terminalis, and part of the nucleus accumbens. Contains brain “stress” neurotransmitter corticotropin-releasing factor that produces dysphoria during withdrawal in addiction.
Prefrontal Cortex (“Craving”)— Structure in the front top of the brain involved in executive function that plays a key role in relapse to addiction. Executive function combines elements of delay in gratification and inhibition to allow healthful choices and decisions. Contains the major excitatory neurotransmitter glutamate that reawakens “craving”.
Substance abuse treatment has proven efficacy, is cost effective, and has gained parity with other medical disorders for reimbursement by 3rd party payorsIdentify and pre-clinically validate novel targetsRe-purpose available drugs and shelved investigational drugs for other indicationsDevelop vaccines and novel routes of administration•Use human laboratory studies for proof of concept •Increase addiction medicine training programs and fellowships to expand the network of prescribers