Thrombus Aspiration in ST- Elevation myocardial infarction in Scandinavia (TASTE trial) Ole Fröbert, MD, PhD - on behalf of the TASTE investigators Departement of Cardiology Örebro University Hospital Sweden Main results at 30 days UCR Uppsala Clinical Research Center
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Thrombus Aspiration in ST- Elevation myocardial infarction in Scandinavia ( TASTE trial)
UCR Uppsala Clinical Research Center. Thrombus Aspiration in ST- Elevation myocardial infarction in Scandinavia ( TASTE trial). Ole Fröbert, MD, PhD - on behalf of the TASTE investigators Departement of Cardiology Örebro University Hospital Sweden. Main results at 30 days. Background. - PowerPoint PPT Presentation
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Thrombus Aspiration in ST- Elevation myocardial infarction in Scandinavia (TASTE trial)
Ole Fröbert, MD, PhD - on behalf of the TASTE investigatorsDepartement of Cardiology
Örebro University Hospital
Sweden
Main results at 30 days
UCRUppsala Clinical Research Center
Background
Intracoronary thrombus aspiration may reduce distal embolization and improve reperfusion
No previous randomized trial on thrombus aspiration has been powered for hard endpoints
Current ESC recommendation: class IIa with a level of evidence B
TAPAS
Vlaar, P.J. et al. The Lancet 2008; 371:1915-20
Fröbert, O. et al. Int J Cardiol. 2010; 145:572-3
TA+PCI (N=3 666)
PCI alone (N=16 417)
HR (95% CI): 1.21 (1.08-1.35)
/ Swedish registry data
Methods (1) All 29 Swedish, 1 Icelandic and 1 Danish PCI center Inclusion criteria
STEMI and ability to provide oral consent <24 h symptoms correspondence between ECG and angio findings
Exclusion criteria need for emergency CABG age <18 years previous randomization in TASTE
1:1 randomization to manual thrombus aspiration and PCI vs. PCI alone
Methods (2) Endorsed aspiration catheters
Eliminate (Terumo), Export (Medtronic) and Pronto (Vascular Solutions)
Anticoagulation and platelet inhibition according to current guideline recommendations
Primary endpoint time to all-cause death at 30 days
Secondary endpoints time to rehospitalization with reinfarction at 30 days time to stent thrombosis at 30 days
Methods (3) TASTE introduces the Registry-based
Randomized Clinical Trial (RRCT) concept
Online health quality registries (SCAAR and SWEDEHEART) serve as on-line platforms for: randomization case record forms follow-up
All patients with STEMI in Sweden and Iceland undergoing