The Isotonix The Isotonix ® Advantage Advantage Mark Lange, Ph.D. Director, Quality Control Market America
The IsotonixThe Isotonix® Advantage Advantage
Mark Lange, Ph.D.
Director, Quality Control
Market America
OVERVIEWOVERVIEW Understanding Your Digestive Understanding Your Digestive
SystemSystem Transporting Nutrients into CellsTransporting Nutrients into Cells The Isotonix Delivery SystemThe Isotonix Delivery System Isotonix Advantage #1,2,3…..Isotonix Advantage #1,2,3…..
STOMACHSTOMACH
Secretes 5 substances mainly:Secretes 5 substances mainly: Water – diluent Water – diluent Chloride ionsChloride ions Hydrogen ionsHydrogen ions Pepsin – proteolytic enzyme (proteins)Pepsin – proteolytic enzyme (proteins) Intrinsic factor – vitamin B-12 binding Intrinsic factor – vitamin B-12 binding
protein released by parietal cellsprotein released by parietal cells
Hydrochloric acid Hydrochloric acid HCl = pH 1.0 – 2.8HCl = pH 1.0 – 2.8
Isotonix Advantage #1
Nutrients are not exposed to acidic environment of stomach, where they would otherwise degrade.
Customer money is not wasted.
Isotonix Advantage #2
Reduced delivery time.
Example: B vitamins for energy
Minutes to uptake – not hours
SMALL INTESTINESMALL INTESTINE ACIDIC FOOD SOLUTIONACIDIC FOOD SOLUTION
stimulates pancreas to release stimulates pancreas to release numerous digestive enzymes in a numerous digestive enzymes in a sodium bicarbonate solutionsodium bicarbonate solution
NEUTRALIZATIONNEUTRALIZATION pH of food pH of food solution changed from acidic to solution changed from acidic to nearly neutral nearly neutral
SMALL INTESTINESMALL INTESTINE BILE is a product of the liver, BILE is a product of the liver,
collected in the gall bladder, and collected in the gall bladder, and secreted onto the food solution.secreted onto the food solution.
Contains surfactants that disperse Contains surfactants that disperse fat.fat.
Lipases act on triglycerides, Lipases act on triglycerides, releasing fatty acids.releasing fatty acids.
Isotonix Advantage #3
Carbon dioxide created by the effervescent reaction reduces the thickness and viscosity of the mucus layer of the intestinal tract, promoting absorption into the cells.
Pharm. Res. 1998, vol 15, pp 925-930. “Mechanistic studies on effervescent-induced permeability enhancement.”
Cell Membrane Barriers
Lipid bi-layers are impermeable to most essential molecules and ions.
Oxygen, Water, & Carbon Dioxide can freely pass.
Many nutrients cannot freely pass.
Movement through Differences in Concentration
Diffusion is moving molecules from a region of higher concentration to a region of lower concentration.
Isotonix Advantage #4
Favorable concentration gradient for absorption of some nutrients. Example: Calcium/Magnesium
Nutrients are delivered to the small intestine in a concentrated solution.
Facilitated Diffusion
Takes place through channels embedded in the membrane.
Example: Fructose moved into cell by facilitated diffusion.
Active Transport Pumping of molecules or ions
through a membrane into a region of higher concentration. It requires a trans-membrane protein and energy input.
Example: Amino Acids, ATP, Sodium, Potassium moved into cell by Active Transport.
SMALL INTESTINESMALL INTESTINE Absorption of nutrients occurs Absorption of nutrients occurs
throughout entire length of small throughout entire length of small intestine (90 – 95% efficient)intestine (90 – 95% efficient)
Calcium absorption occurs as late as Calcium absorption occurs as late as ileo-cecal juncture (appendix) ileo-cecal juncture (appendix) transport into cells via calcium channelstransport into cells via calcium channels
Under neutral pH, intrinsic factor binds Under neutral pH, intrinsic factor binds to vitamin B-12 to form a complexto vitamin B-12 to form a complex
SMALL INTESTINESMALL INTESTINE Intrinsic factor/vitamin B-12 complex Intrinsic factor/vitamin B-12 complex
binds to receptors (specialized binds to receptors (specialized docking structures) on intestinal docking structures) on intestinal membranesmembranes
Last 1/3Last 1/3rdrd of small intestine is main of small intestine is main absorptive siteabsorptive site
COLONCOLON Most nutrients will have been absorbed by the Most nutrients will have been absorbed by the
time they reach the large intestine —an time they reach the large intestine —an additional 3-5% possible.additional 3-5% possible.
Major functions of colon:Major functions of colon: Site of bacterial cell growth and residenceSite of bacterial cell growth and residence An estimated 300-400 species or strains of An estimated 300-400 species or strains of
bacteria continue digestion of waste bacteria continue digestion of waste productsproducts
Regulates water in bodyRegulates water in body Some vitamins produced in low amounts by Some vitamins produced in low amounts by
bacteria and absorbedbacteria and absorbed
COLONCOLONBacteria adjust the pH of the colon into Bacteria adjust the pH of the colon into the acidic range – prevents overgrowth the acidic range – prevents overgrowth of harmful bacteria.of harmful bacteria.
Continued growth of friendly bacteria Continued growth of friendly bacteria help maintain healthy balance.help maintain healthy balance.
What does “isotonic” What does “isotonic” mean?mean?
ISO = SAMEISO = SAME
TONIC = Tension or PressureTONIC = Tension or Pressure
An Isotonic Cell is a Happy Cell.An Isotonic Cell is a Happy Cell.
Cells act like little bags of salty water…..
The movement of water in and out of a cell is called “Osmosis.”
Cells want the same concentration
of dissolved particles (salt) on both sides of the membrane.
Isotonix Advantage #5
Isotonic solutions are the optimal delivery system.
Isotonix products work with – not against – normal body physiology.
Composition of Composition of Isotonix Delivery Isotonix Delivery SystemSystem
Active ingredients:Active ingredients: vitamins, vitamins, minerals, oligomeric minerals, oligomeric proanthocyanidins (OPC), proanthocyanidins (OPC), flavonoids, coenzyme Q10, etc.flavonoids, coenzyme Q10, etc.
Base ingredients:Base ingredients: fructose, fructose, glucose, citric acid, malic acid, glucose, citric acid, malic acid, calcium sulfate, maltodextrin, calcium sulfate, maltodextrin, silica, potassium bicarbonatesilica, potassium bicarbonate
Composition of Composition of Isotonix Delivery Isotonix Delivery SystemSystem Glucose and fructoseGlucose and fructose: :
Sweet-tasting simple sugarsSweet-tasting simple sugars Add significant osmotic pressureAdd significant osmotic pressure Caloric value (Caloric value (~ 8 cal/serving)~ 8 cal/serving) Fructose: principle sugar in formula Fructose: principle sugar in formula
scores 20 out of 100 on glycemic scores 20 out of 100 on glycemic index (i.e., relatively low value)index (i.e., relatively low value)
Composition of Composition of Isotonix Delivery Isotonix Delivery SystemSystem
Citric acid and malic acidCitric acid and malic acid: : Adjust pH to acid range (about 3.5 – Adjust pH to acid range (about 3.5 –
5.0)5.0) Adjust taste to “citrus” flavorAdjust taste to “citrus” flavor Minor osmotic pressure adjustmentMinor osmotic pressure adjustment
Composition of Composition of Isotonix Delivery Isotonix Delivery SystemSystem
Calcium sulfateCalcium sulfate: : Desiccant (takes up moisture in Desiccant (takes up moisture in
powder) / free-flow agent powder) / free-flow agent Minor osmotic pressure adjustmentMinor osmotic pressure adjustment Minor nutritive valueMinor nutritive value
Composition of Composition of Isotonix Delivery Isotonix Delivery SystemSystem
MaltodextrinMaltodextrin: : Glucose polymer has minor caloric Glucose polymer has minor caloric
valuevalue Powder — bulking agentPowder — bulking agent Prevents citric acid from reacting with Prevents citric acid from reacting with
potassium bicarbonate and waterpotassium bicarbonate and water Thickening and suspending agent in Thickening and suspending agent in
solutionsolution
Composition of Composition of Isotonix Delivery Isotonix Delivery SystemSystem
Potassium bicarbonatePotassium bicarbonate: : Potassium and bicarbonate ions have Potassium and bicarbonate ions have
significant osmotic pressure significant osmotic pressure Helps adjust and buffer pHHelps adjust and buffer pH Release of CORelease of CO2 2 stirs liquidstirs liquid
Isotonix Advantage #6 Isotonix offers an alternative to
pills.
Survey shows 40% of American adults have experienced difficulty swallowing pills
The survey of 679 adults (513 ages 18-64, 166 age 65 and older) was funded by
the US affiliate of Germany's Schwarz Pharma.
Isotonix Advantage #7 People with stomach and esophageal
challenges benefit from Isotonix delivery. Acid reflux sufferers Bariatric patients Hiatal Hernia (stomach protrudes up
through diaphragm) People who have trouble swallowing Elderly (reduced acid production)