Isotonix opc 3

The Health Benefits ofThe Health Benefits of

Isotonix OPC-3Isotonix OPC-3®®

Mark Lange, Ph.D.

James Wilmer, Ph.D.

Market America, Inc.

Statements have not been Statements have not been evaluated by the Food and evaluated by the Food and Drug Administration. This Drug Administration. This product is not intended to product is not intended to diagnose, treat, cure or diagnose, treat, cure or

prevent any disease.prevent any disease.

Primary BenefitsPrimary Benefits

Although there are many potential Although there are many potential uses for Isotonix OPC-3uses for Isotonix OPC-3®®, the most , the most common are:common are:

Helps maintain normal, healthy Helps maintain normal, healthy circulationcirculation

Helps promote cardiovascular health.Helps promote cardiovascular health.

Pharmacological ActionsPharmacological Actions

Helps maintain normal blood glucose Helps maintain normal blood glucose levelslevels

Supports normal platelet activitySupports normal platelet activity Powerful free radical scavengerPowerful free radical scavenger Demonstartes anti-inflammatory Demonstartes anti-inflammatory

actionaction Supports healthy endothelial functionSupports healthy endothelial function

Serving SizeServing Size

The serving size for a healthy The serving size for a healthy individual for general health individual for general health maintenance is given on the label maintenance is given on the label (one capful per day).(one capful per day).

Consult with your healthcare Consult with your healthcare provider before taking additional provider before taking additional servings per day.servings per day.

Duration of UseDuration of Use

Most people see the benefit of Most people see the benefit of Isotonix OPC-3Isotonix OPC-3®® within 8-12 weeks. within 8-12 weeks.

Given Isotonix OPC-3’s long history of Given Isotonix OPC-3’s long history of use by thousands of satisfied use by thousands of satisfied customers, no limitation on length of customers, no limitation on length of use is indicated.use is indicated.

Quality of IngredientsQuality of Ingredients

Isotonix OPC-3Isotonix OPC-3®® is blended using the is blended using the finest ingredients available. Each finest ingredients available. Each ingredient is affirmed GRAS ingredient is affirmed GRAS (generally recognized as safe), free (generally recognized as safe), free of pesticide residue and in of pesticide residue and in compliance with USP and FDA compliance with USP and FDA requirements for purity.requirements for purity.

Isotonix OPC-3Isotonix OPC-3®® Contains Contains PycnogenolPycnogenol®®

Pycnogenol Pycnogenol is a proprietary extract of the is a proprietary extract of the French maritime pine bark. French maritime pine bark.

Pycnogenol contains oligomeric Pycnogenol contains oligomeric proanthocyanidins (OPCs) as well as other proanthocyanidins (OPCs) as well as other bioflavonoids. bioflavonoids.

Only Isotonix products have Pycnogenol in Only Isotonix products have Pycnogenol in isotonic delivery form.isotonic delivery form.

Proanthocyanidins are found Proanthocyanidins are found in grape seed extract, pine in grape seed extract, pine

bark and red wine.bark and red wine.

How do OPCs Protect How do OPCs Protect Tissue from Free Radical Tissue from Free Radical

Attack?Attack? They donate electrons from the They donate electrons from the

hydroxyl (–OH) group.hydroxyl (–OH) group. Donated electron stabilizes Donated electron stabilizes

(inactivates) free radicals.(inactivates) free radicals. Then forms a stable intermediate Then forms a stable intermediate

that will not react with tissue.that will not react with tissue. Vitamin C recycles (regenerates) Vitamin C recycles (regenerates)

OPCs’ antioxidant capability.OPCs’ antioxidant capability.

OPCs Help ProtectOPCs Help ProtectTissues and CellsTissues and Cells

Lipids, proteins and DNA are targets Lipids, proteins and DNA are targets for free radical attack.for free radical attack.

Free radicals not only directly cause Free radicals not only directly cause cell injury, they can also act as cell injury, they can also act as signals for pro-inflammatory signals for pro-inflammatory pathways.pathways.

Helps prevent oxidative stress in the Helps prevent oxidative stress in the human body.human body.

Human Cells have fat-like and Human Cells have fat-like and water-like regions; where water-water-like regions; where water-

soluble and fat-soluble soluble and fat-soluble antioxidants resideantioxidants reside

Lipid bilayer (cell wall)

Fat-like region

Water-like region

Cytoplasm

OPC-3OPC-3®® and Cardiovascular and Cardiovascular HealthHealth

Endothelial cells line the inner wall of Endothelial cells line the inner wall of blood vessels. Endothelial cell health is an blood vessels. Endothelial cell health is an important factor in cardiovascular health.important factor in cardiovascular health.

The endothelium also helps control blood The endothelium also helps control blood pressure through vasorelaxation. pressure through vasorelaxation.

Pycnogenol stimulates nitric oxide Pycnogenol stimulates nitric oxide production which promotes normal production which promotes normal vasorelaxation (dilation of blood vessels).vasorelaxation (dilation of blood vessels).

Accelerated antioxidant bioavailability of Accelerated antioxidant bioavailability of OPC-3OPC-3®®

bioflavonoids administered as bioflavonoids administered as isotonic solutionisotonic solution

Cesarone et al. Phytotherapy Research 23, 775-777(2009)Cesarone et al. Phytotherapy Research 23, 775-777(2009)

10 subjects (5 male, 5 female), 24-45 years, 10 subjects (5 male, 5 female), 24-45 years, healthy,healthy,

non-smokers with elevated plasma oxidative stressnon-smokers with elevated plasma oxidative stress

Subjects took:Subjects took: OPC-3 first in isotonic form, then 1 week later OPC-3 first in isotonic form, then 1 week later

OPC-3 in tablet form (with equivalent OPC-3 in tablet form (with equivalent water)water)

Plasma antioxidant effect was monitored over a 4 Plasma antioxidant effect was monitored over a 4 hour period.hour period.

Isotonic OPC-3Isotonic OPC-3®® versus versus OPC-3OPC-3®® in tablet form. in tablet form.

Reduced plasma oxidative stress Reduced plasma oxidative stress (increase in plasma radical reduction rate (increase in plasma radical reduction rate to baseline) within 10 minutes.to baseline) within 10 minutes.

Plasma free radical values always Plasma free radical values always remained lower throughout the 4 hours.remained lower throughout the 4 hours.

Biphasic absorption noted:Biphasic absorption noted: first phase- rapid absorption and first phase- rapid absorption and

antioxidant effect from monomeric and antioxidant effect from monomeric and dimeric species.dimeric species.

second phase- may involve absorption second phase- may involve absorption of larger molecules, maximizing at 70 of larger molecules, maximizing at 70 mins. mins.

Time after consumption [min]

Start 10 20 30 40 50 60 70 80 90 120 150 180 210 240

Plas

ma

radi

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educ

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rate

to b

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[uni

ts/m

in]

0.0

0.5

1.0

1.5

2.0

2.5

3.0OPC-3® isotonic formulationOPC-3® tablet

Time after consumption [min]

Start 10 20 30 40 50 60 70 80 90 120 150 180 210 240

Plas

ma

radi

cal r

educ

tion

rate

to b

asel

ine

[uni

ts/m

in]

0.0

0.5

1.0

1.5

2.0

2.5

3.0OPC-3® isotonic formulationOPC-3® tablet

In this publication, the authors In this publication, the authors conclude:conclude:

““In conclusion the findings In conclusion the findings demonstrate that the flavonoid demonstrate that the flavonoid mixture provided in isotonic OPC-mixture provided in isotonic OPC-33®® is significantly more is significantly more bioavailable in humans, in terms of bioavailable in humans, in terms of antioxidant activity than an antioxidant activity than an equivalent mixture in tablet form.”equivalent mixture in tablet form.”

SummarySummary

Isotonix OPC-3Isotonix OPC-3®® provides isotonic delivery provides isotonic delivery of Pycnogenol, along with other sources of of Pycnogenol, along with other sources of active bioflavonoids.active bioflavonoids.

Isotonix OPC-3Isotonix OPC-3®® promotes cardiovascular promotes cardiovascular health and normal flood vessel function.health and normal flood vessel function.

Isotonix OPC-3Isotonix OPC-3®® is a safe, all-natural is a safe, all-natural supplement known for a wide range of supplement known for a wide range of health benefits.health benefits.