The History of DNA

The History of DNA

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Gregor Mendel1865

Frederick Miescher•Embryologist

•He collected bandages from nearby clinicAnd wash off the pus.

•Isolated a new molecule NUCLEIN from the cells nucleus in 1869. •H,N, P, and O

•1871 He publish his findings.

•Proteins were the molecule of heredity

•Die of tuberculosis in 1895.1844- 1895

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FREDRICK GRIFFITH

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http://www.nature.com/scitable/topicpage/isolating-hereditary-material-frederick-griffith-oswald-avery-336

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OSWALD AVERYCOLIN MACLEOD

MACLYN McCARTYhttp://profiles.nlm.nih.gov/CC/Views/Exhibit/visuals/after.html

Avery Experiment

1944

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LINUS PAULING1948

http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/dna/narrative/page1.html

He proposed that the DNA structure was a triple helix, though he was later disproven.

The fact that he determined DNA to be three dimensional is still a much celebrated accomplishment

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ERWIN CHARGAFF1950

Chargaff's observation that in the base composition of DNA the quantity of adenine equaled the quantity of thymine and the quantity of guanine equaled the quantity of cytosine

A = TC = G

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Organisms A T G CHomo sapiens 31 31.5 19.1 18.4

Drosophila melanogaster 27.3 27.6 22.5 22.5

Zea mays 25.6 25.3 24.5 24.6

Neurospora crassa 23 23.3 27.1 26.6

Escherichia coli 24.6 24.3 25.5 25.6

Bacillus subtilis 28.4 29 21 21.6

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MAURICE WILKINS

ROSALIND FRANKLIN1951

http://gandt.blogs.brynmawr.edu/web-papers/web-papers-2/women-in-science/

Rosalind Franklin•English Biologist

•Made and X-ray of DNA.

•She was an instrument in discovering the structure of DNA. •Also Known as the Dark Lady of the DNA

•X-ray diffraction specialist.

•X-Ray 51

•Die in 1958 at age of 37 of ovarian cancer.

04/22/2023 12http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/dna/narrative/page1.html

X-Ray 51

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MARTHA CHASE ALFRED HERSHEY

http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/dna/narrative/page1.html

1952

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FRANCIS CRICK AND JAMES WATSON1953

http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/dna/narrative/page1.html

04/22/2023 16http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/dna/narrative/page1.html

04/22/2023 17http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/dna/narrative/page1.html

Noble Price 1962

04/22/2023 18http://commons.wikimedia.org/wiki/File:DNA-structure-and-bases.png

04/22/2023 19http://commons.wikimedia.org/wiki/File:Nucleotides_1.svg

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