The Differences of Depth Parameters of The Differences of Depth Parameters of Deposits Depending on the Morphology in Deposits Depending on the Morphology in Granular Corneal Dystrophy Type Granular Corneal Dystrophy Type Ⅱ Ⅱ by Fourier by Fourier Domain Optical Coherence Tomography Domain Optical Coherence Tomography Jin Pyo Hong,MD Jin Pyo Hong,MD 1 , Jae Lim Chung,MD , Jae Lim Chung,MD 1 , Jung Won , Jung Won Park,MD Park,MD 2 , Tae-im Kim,MD,PhD , Tae-im Kim,MD,PhD 1 , Kyoung Yul Seo,MD,PhD , Kyoung Yul Seo,MD,PhD 1 , , Eung Kweon Kim,MD,PhD Eung Kweon Kim,MD,PhD 1 1 Corneal Dystrophy Research Institute, Department of Corneal Dystrophy Research Institute, Department of Ophthalmology, College of Medicine, Yonsei University, Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea Seoul, Korea 2 Daegu Yonsei Eye Clinic, Daegu, Korea Daegu Yonsei Eye Clinic, Daegu, Korea Authors have no financial interest
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The Differences of Depth Parameters of Deposits Depending on the Morphology in Granular Corneal Dystrophy Type Ⅱ by Fourier Domain Optical Coherence Tomography.
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The Differences of Depth Parameters of Deposits The Differences of Depth Parameters of Deposits Depending on the Morphology in Granular Corneal Depending on the Morphology in Granular Corneal
Dystrophy Type Dystrophy Type ⅡⅡ by Fourier Domain Optical Coherence by Fourier Domain Optical Coherence TomographyTomography
Jin Pyo Hong,MDJin Pyo Hong,MD11, Jae Lim Chung,MD, Jae Lim Chung,MD11, Jung Won , Jung Won
11Corneal Dystrophy Research Institute, Department of Ophthalmology, College Corneal Dystrophy Research Institute, Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Koreaof Medicine, Yonsei University, Seoul, Korea22Daegu Yonsei Eye Clinic, Daegu, KoreaDaegu Yonsei Eye Clinic, Daegu, Korea
Authors have no financial interest
Purpose
Granular corneal dystrophy typeⅡ (GCDⅡ) Arg124His mutation in the Bigh-3 gene Histologic feature of hyaline granules and amyloid lattice lines Granular deposits as the earliest manifestation Lattice deposits as later presentation Diffuse haziness as getting older
Surgical treatment of GCDⅡ Phototherapeutic keratectomy(PTK) Penetrating keratoplasty(PKP) Lamellar keratoplasty(LKP)
The depth of different deposits according to the patterns Should be identified before surgery Critical to decide which treatment modalities Such as PTK, PKP, LKP
Purpose
Fourier domain optical coherence tomography, RTVue-100®(Optovue Inc, Fremont, CA) High speed, high resolution tomography scanning 5 μm depth resolution Layer by layer assessment 26,000 A scan/second 0.04 second of one B scan acquisition
Purpose of this study To evaluate the differences of depth parameters depending on morphology
of deposits using Fourier domain optical coherence tomography, RTVue-100®
Methods
Patients 54 patients were evaluated Heterozygous GCDⅡ by gene analysis No history of uveitis, glaucoma, other ocular surface disease, previous
operation
Methods Standardization of measuring CCT for RTVue-100® with ultrasonic pachymeter
The differences of depth between trunks and limbs of lattice with long branches (Type IIIb)
Parameters of lattice(n=74)P
Trunks limbs
USBL 67.1±52.5 165.0±110.1 <0.0001
LSBL 321.9±80.3 289.4±117.2 0.208
TD 253.0±75.3 125.7±40.9 <0.0001
Parameters of recurrent deposits after LASIK (n=15)
Parameters mean±SD (min – max)
Mean depth of center of deposits 84.9±43.6 (22 – 191)
Mean maximum thickness 85.6±24.9 (47 – 125)
Mean minimum thickness 45.1±18.0 (22 – 85)
Conclusion
1st report investigating in vivo the depth of deposits depending on the morphology
Three deposits had three distinct depths Diffuse haziness at the superficial layer Granules at ant. stroma Lattice deposits at mid to post. Stroma
No differences of depth between two shaped lattice deposits Easily detected by RTVue-100® in case slit lamp examination
can not reveal the depth Most of all
Guide the treatment modality according to what the main pattern of deposits are in the visual axis, such as PTK, DLKP, PKP by in vivo measuring with RTVue-100®