The Department of Defense Laboratory Based Global Influenza Surveillance Program Linda C. Canas Brooks City-Base, TX (210)536-1679
Dec 24, 2015
The Department of Defense Laboratory Based
Global Influenza SurveillanceProgram
Linda C. Canas
Brooks City-Base, TX
(210)536-1679
Population Based Surveillance
Naval Health Research Center
San Diego, California
DoD Global Influenza Surveillance
AF Institute forOperational HealthBrooks City-BaseSan Antonio, Texas
Influenza Surveillance Influenza Surveillance
DoD GEIS
Laboratory
Funding & Guidance
Routine & Annual Reports; End of Season business meeting
Supplies and Instructions Program
Guidance& routine reports
Collect and ship Samples
Info entered into AF database
Flu Isolated
Conventional Laboratory Methods
Sentinel Sites
Notification
CDCVaccine
DecisionsSelected Samples
DoD Global Influenza SurveillanceDoD Global Influenza Surveillance ..................................IN ACTIONIN ACTION
Epi Services Branch
2003-2004 Influenza Sentinel Sites
New Sentinel Bases
SENTINEL SITES
RAF Lakenheath, U.K.Ramstein AB, GermanySheppard AFB, TXTravis AFB, CAYokota AB, Japan
DeployedAl-Udeid AB, QatarGanci AB, Kyrgyzstan
Overseas Research Sites Armed Forces Research Institute of Medical Sciences (AFRIMS), THAILAND, NEPAL, MALDIVESNaval Medical Research Institute Detachment (NAMRID)
PERU, ECUADOR, BOLIVIA, ARGENTINA, NICARAGUA Walter Reed Army Institute of Research (WRAIR), UGANDA
Army (1)Tripler AMC, HI
Navy/Coast Guard (6)NAB Little Creek, VANH Yokosuka, JapanNMC San DiegoNH Pearl Harbor, HINH BremertonCGS Ketchikan
Air Force (18)Andersen AFB, GuamAir Force Academy, COAndrews AFB, MDAviano AB, ItalyElmendorf AFB, AKHickam AFB, HIIncirlik AB, TurkeyKadena AB, JapanKunsan AB, R.O.K. Maxwell AFB, ALMcGuire AFB, NJMisawa AB, JapanOsan AB, R.O.K.
N=2946Pos=1310Flu A=941
Asia/Pacific: Isolates
N=319
Pos=128
Flu A = 91
North America: Isolates
N=2178
Pos=1036
Flu A=739
South America: Isolates
N=217Pos=61Flu A=26
Europe: Isolates
N=174Pos=74
FluA=64
Deployed: Qatar and Afghanistan
N=58Pos=21
Flu A=21
Percent Positive Isolates by Type
Percent of Positive Isolates
10 nucleotides
bafb-Korea5844-2003bafb-IL5173-2003
bafb-TX4106-2003bafb-Korea5834-2003IA32003
bafb-CO4521-2003VA162003
bafb-DC4081-2003bafb-VA3909-2003
NH22003CO62003
bafb-CO5217-2003bafb-CA5218-2003
bafb-DC4069-2003bafb-CO4634-2003bafb-DC4058-2003bafb-DC4059-2003bafb-DC4072-2003bafb-DC4086-2003bafb-DC4087-2003bafb-Korea5642-2003bafb-Qatar4001-2003bafb-Qatar5681-2003bafb-TX4105-2003bafb-TX4295-2003bafb-VA4383-2003bafb-VA4863-2003bafb-VA5259-2003
bafb-VA5185-2003bafb-CA4640-2003TX1512003bafb-TX4104-2003
bafb-VA5256-2003WI492003
GA282003MO152003
SC62003FL102003
bafb-TX4102-2003bafb-VA4620-2003
bafb-AL4041-2003LA42003
bafb-AL4623-2003bafb-CA4644-2003
Egypt72212003UT12003
NY762003bafb-Peru5034-2003
bafb-Peru5041-2003bafb-WA4605-2003
bafb-CA4507-2003bafb-DC5225-2003
bafb-AL4553-2003bafb-TX3825-2003
bafb-England3968-2003DC42003
CT22003ChristChurch282003
WA72003bafb-Ger5254-2003
bafb-CA4641-2003bafb-TX4107-2003bafb-NM4245-2003
bafb-WA4331-2003bafb-Qatar4353-2003bafb-Qatar4352-2003bafb-Qatar4350-2003bafb-Qatar4094-2003bafb-NM4601-2003bafb-NM4598-2003bafb-Korea5842-2003bafb-Korea5840-2003bafb-Korea5733-2003bafb-Korea5730-2003bafb-Korea5647-2003bafb-CO4636-2003
bafb-Korea5624-2003bafb-Japan5686-2003WY562003
Memphis322003OK82003VT82003ID62003KS32003
bafb-HI5860-2003bafb-NM4089-2003
bafb-VA5187-2003NM172003
bafb-Guam4692-2003bafb-Guam4693-2003bafb-Guam4694-2003bafb-HI4269-2003
bafb-VA5682-2003bafb-VA5800-2003
bafb-VA5264-2003WV82003bafb-VA3994-2003
bafb-Japan2990-2003Taiwan15292003
Taiwan15302003HK11732003
HK11602003HK11862003
Wuhan2142003Fujian4452003
Shanghai3692003bafb-Guam5685-2003
Guam37152003NE62003bafb-Guam3267-2003
Fujian4112002HK63852003
Korea7702002HK10522003
bafb-Peru3162-2003ES362003bafb-Peru3209-2003
bafb-Peru5028-2003bafb-Ger4403-2003
bafb-MI3904-2003bafb-nu5095-2003
bafb-Peru5037-2003bafb-Peru5038-2003bafb-Peru5035-2003
bafb-Peru3223-2003bafb-Peru3233-2003
bafb-Peru3231-2003bafb-Peru3239-2003
bafb-Peru3186-2003OR12003TX272003
bafb-ND2463-2003Wyoming/3/2003
HK62052003PY1292003
Panama/2007/99
N 126 D
K 140 E
S 227 P
H3 HA
Evolutionary Relationship Among Evolutionary Relationship Among Influenza A H3N2 Hemagglutinin Influenza A H3N2 Hemagglutinin
(HA1)(HA1)(2003(2003--2004 Season)2004 Season)
•90 (globally isolated) H3N2 viruses sequenced to date•100% (90/90) have the Fujian-like 155/156 AA change•22% contain the K140E AA substitution
Phylogeny courtesy of Dr. Mike Shaw Centers for Disease Control
Summary 2003-2004
Overall this has been an exceptional year
Monotype season more so than past 5 years
A/H3N2 in most locationsFew Influenza B and A/H1N1. No H5/H7 at this point.
Molecular AnalysisH3N2 viruses: nearly 100% variant from vaccine strain