Vascular function as an early sign of trouble: How can the inhibition of cholesterol absorption reduce the atherogenic load of intestinal lipoproteins? Prof Frank Visseren, MD Academic Medical Centre Utrecht The Netherlands Master Class Lipid Innovations Prague, Czech Republic May 27-28, 2011 Slide lecture prepared and held by: Presentation topic
29
Embed
The concept of Diabetes & CV risk: A lifetime risk challenge
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
The concept of Diabetes & CV risk:A lifetime risk challenge
Vascular function as an early sign of trouble: How can the inhibition of cholesterol absorption reduce the
atherogenic load of intestinal lipoproteins?
Prof Frank Visseren, MDAcademic Medical Centre UtrechtThe Netherlands
Master Class Lipid InnovationsPrague, Czech RepublicMay 27-28, 2011
Slide lecture prepared and held by:
Presentation topic
Overview of Cholesterol Transport
Altman SW et al. Science 2004;303:1201-1204
Cholesterol transporter
Postprandial lipidemia
Postprandial lipids (triglyceride-rich lipoprotein or lipoprotein-remnant particles) are associated with:
Statin monotherapy and Ezetimibe monotherapy preserve post-fatload endothelial function
Combination of low-dose statine with ezetimibe preserve post-fatload endothelial function
But: small studies
The PostprAndial eNdothelial function After Combination of Ezetimibe and
simvAstatin (PANACEA) Study
The PostprAndial eNdothelial function After Combination of Ezetimibe and simvAstatin (PANACEA) Study
Primary objective:
To evaluate the effect of simvastatin/ezetimibe or high-dose simvastatin alone on fasting and postprandial endothelial function as measured with FMD and EndoPat in obese patients with metabolic syndrome.
The PostprAndial eNdothelial function After Combination of Ezetimibe and simvAstatin (PANACEA) Study
Study design:
Randomized, double blind2 period cross-over100 patients 5 centers in The Netherlands and Spain