Temperature Regulation The Reverend Dr. David CM Taylor http://pcwww.liv.ac.uk/~dcmt/Tem preg.ppt
Temperature RegulationThe Reverend Dr. David CM Taylor
http://pcwww.liv.ac.uk/~dcmt/Tempreg.ppt
Why temperature regulation?
• (The 19th century experiences of puerperal fever and the hospital as a ‘gateway to death’ are historical reminders of advances made.) “Birth is big for babies too - many changes. …Keep Baby warm.” In the postnatal ward, Mrs Cheung asks, “Can I feed her? Why are you taking my temperature? I’d like my aromatherapy!”.
What we will cover
Triggered by elements in the case scenario we will consider:
• Why we regulate temperature?• What is meant by “normal” body temperature• What mechanisms there are for regulating body
temperature (and the importance of behavioural mechanisms.
• How babies are different from adults.• How fever occurs.
Why?
• All organisms are limited by their ability to survive in different temperatures
• Some, like reptiles and amphibia are poikilothermic• Others like humans are homeothermic
How?
• The actual body temperature is a consequence of the balance between the amount of heat produced and the amount of heat lost. The balance may be altered
• physiologically or
• behaviourally
Basal metabolic rate
Muscle activity
Shivering
Vasomotor
Sweating
Piloerection
Conduction
Convection
Radiation
Evaporation
Body Skin Environment
Balance
Core Temperature
Reference
Response
Controlled system
Feedback
Set-point Set-point hypothesishypothesis
So how is it regulated?
Response
Controlled system
Feedback
Balance hypothesisBalance hypothesis
Feedback
warmcool
Inputs Outputs
Hypothalamus
Central thermosensors
warm cool
Peripheral thermosensors
warm cool
Neuralsweatingshivering
vasoconstrictionvasodilation
Hormonaladrenaline
TRH
Babies• Babies (and hamsters) have an
extra mechanism
• Brown fat.• Suprascapular deposits• Rich in mitochondria
Normal body temperature
• Depends where and when you measure it
• tympanic> oral > axillary by 0.5oC
• can be affected by• exercise
• emotion
• time of day
RectaltempOC
37.4
36.8
36.2
12 18 624 12Time
Postovulatory
Preovulatory
And the menstrual cycle (o- p+)
Fever
• monocytes and phagocytes release endogenous pyrogen (Interleukin-1, IL-1).
• The anterior hypothalamus is sensitive to IL-1
• Hypothalamic sensitivity to temperature is altered.
So…
• The body temperature then becomes regulated at a new, higher level.
• There is some evidence that the raised body temperature enables the fight against the infection.
But...
• Every 1OC rise in temperature increases basal metabolic rate and oxygen consumption by about 13%,
• In acute infection, the ability to mobilise fat stores is inhibited.
Consequently
• Skeletal muscle is broken down and the amino acids are used in gluconeogenesis.
• This can be debilitating.
And even worse
• In addition to the increased demand for energy
• Temperatures (above 42OC) damage nerve cells• impair thermoregulation
• have more serious consequences.