Teknologi Farmasi - Introduction to Tablet

Teknologi Farmasi

Najma Annuria Fithri

TK TK Melati, Sungailiat Bangka SD Koonawara Primary School, Perth WA SMP Al-Kautsar, Bandar Lampung SMA Al-Kautsar, Bandar Lampung S1 Farmasi UGM, Yogyakarta Apt Farmasi UGM, Yogyakarta S2 Ilmu Farmasi Sains dan Teknologi UGM, Yogyakarta

CP: [email protected]

Introduction

Nilai mutlak

Ujian akhir (50%) Tugas (20%) Kuis (20%) Keaktifan di kelas (10%)

Sistem Penilaian

Pengempaan Tablet

Problems in Tablet Compressing1.Capping and LaminationCapping:- Partial or complete separation of top or bottomcrowns of tablet main body.Lamination:- Separation of a tablet into two or more distinctlayers.

Reasons: less binder, powder too dry, compression force too high, compression process too fast

2. Picking and StickingPicking:-Adherence of the tablet material from the surface of a tablet by a punchSticking:-Adherence of tablet material to the die walls resulting in chipping of tablet edges producing rough edges and causing the lower punches uneasy to move resulting in damage of cam tracks and punch faces

Reasons: less binder, less antiadherent, powder too wet/sticky

3. Weight variation too high

Reasons: powder has poor flowing ability, compression speed too fast, granules powder too big/too diverse

Compactibility & Compressibility

Compactibility: is the ability of the powdered material to be compressed into a tablet of specific tensile strength

Compressibility: its ability to decrease in volume under pressure

Compact: static Compress: dinamic

Uses the parameter F (Force):Shows the depth of upper punch needed to compress a tablet to the strength of 0 kg

F>400, poor compactibilityNeed to be combined with a filler (excipient) with F value less than 400

Compactibility

Compressibility

A Sebutkan macam deformasi dan jelaskan Alat untuk mengukur ‘stress’ saat

pengempaan

B Sebutkan amcam permasalahan yang timbul

saat pencetakan dan pengatasannya Macam alat pencetakan tablet

Quiz

C Macam interaksi yang terjadi agar terbentuknya

tablet dari serbuk (minimal 3), jelaskan Sebutkan 3 bagian utama dari mesin tablet

D Gambarkan dan jelaskan kurva profil

pengempaan baik untuk saat terjadinya pengempaan dan saat penarikan punch atas

Perbedaan kompaktibilitas dan kompresibilitas

Quiz