Synthetic Biology Project Examples http://2010.igem.org/Main_Page
Dec 30, 2015
Synthetic Biology Project Exampleshttp://2010.igem.org/Main_Page
Medicine
Energy
Environment
Technology
Medicine
Synthetic Biology Offers New Hope For Malaria Victims
March 24, 2004
According to the WHO, each year nearly 500 million people become infected with malaria, and nearly three million — mostly children — die from it.
"By inserting genes from three separate organisms into the E. coli, we're creating a bacterial strain that can produce the artemisinin precursor, amorphadiene. We are now attempting to clone the remaining genes needed for the E. coli to produce artemisinin." -- chemical engineering professor Jay Keasling
Energy
2008 Project by Harvard iGEM Team
http://2008.igem.org/Team:Harvard
Shewanella oneidensis MR-1
Four 2009 iGEM Projects
http://2009.igem.org/Team:HKU-HKBU
http://2009.igem.org/Team:HKU-HKBU/Assembly#Step_6._Using_the_Speed_Controller
http://2009.igem.org/Team:HKU-HKBU/Assembly#Step_6._Using_the_Speed_Controller
http://www.youtube.com/watch?v=mbzObmQKJSo
http://2009.igem.org/Team:Wash_U
Environment
Edinburgh iGEM 2006
Awards: Best Real World Application, Best Poster
Poison Water
• Arsenic poisoning affects 100 million people
• Serious in Bangladesh
• Wells tap sedimentary layer with Arsenic• 1 in 4 wells contaminated
• Testing methods expensive, require instruments and expertise
Range of Outputs
If no arsenic is present: Urease raises the pH to 9-10
If 5 ppb arsenic is present: Repressor shuts down Urease, pH remains neutral, pH 7
If 20 ppb arsenic is present: LacZ produced, pH 4.5
Project Summary
Our team have designed and modelled a biosensor that can detect several different concentrations of arsenic and emit a pH signal in response. The device can detect the WHO guideline level of 10 ppb and the Bangladeshi standard of 50 ppb for arsenic in drinking water. A proof of concept Biobrick construct has shown a pH response to a concentration of arsenic of 5 ppb.
Technology
http://parts.mit.edu/igem07/index.php/Peking
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