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Synthetic biology www.dule.fr [email protected] Dušan Mišević Petnica, 26. 3. 2016.
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Synthetic biology misevic

Jan 16, 2017

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Page 1: Synthetic biology misevic

Synthetic biology

[email protected]

Dušan MiševićPetnica, 26. 3. 2016.

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"an emerging discipline that uses engineering principles to design and assemble biological components"

Wellhausen, Rachel, and Kenneth A. Oye. "Intellectual Property and the Commons in Synthetic Biology: Strategies to Facilitate an Emerging Technology." Science, Technology and Innovation Policy, 2007 Atlanta Conference on. IEEE, 2007.

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"an emerging discipline that uses engineering principles to design and assemble biological components"

Wellhausen, Rachel, and Kenneth A. Oye. "Intellectual Property and the Commons in Synthetic Biology: Strategies to Facilitate an Emerging Technology." Science, Technology and Innovation Policy, 2007 Atlanta Conference on. IEEE, 2007.

"designing and constructing biological modules, biological systems, and biological machines for useful purposes."

Nakano, Tadashi (2013). Molecular Communication. Cambridge.

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"an emerging discipline that uses engineering principles to design and assemble biological components"

Wellhausen, Rachel, and Kenneth A. Oye. "Intellectual Property and the Commons in Synthetic Biology: Strategies to Facilitate an Emerging Technology." Science, Technology and Innovation Policy, 2007 Atlanta Conference on. IEEE, 2007.

"designing and constructing biological modules, biological systems, and biological machines for useful purposes."

Nakano, Tadashi (2013). Molecular Communication. Cambridge.

“design and construction of novel artificial biological pathways, organisms or devices, or the redesign of existing natural biological systems."

http://www.synbioproject.org/topics/synbio101/definition/

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Synthetic biology

Genetic engineering

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Common circuit diagram symbols (US symbols)

Synthetic Biology Open Language (SBOL) standard visual symbols for use with BioBricks Standard

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Gardner, Timothy S., Charles R. Cantor, and James J. Collins. "Construction of a genetic toggle switch in Escherichia coli." Nature 403.6767 (2000): 339-342.

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Number of Regions: 5Number of teams: 280Number of participants: 5018

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The Edinburgh University 2009 iGEM Team

The Edinburgh University 2009 iGEM Team

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The Edinburgh University 2009 iGEM Team

https://playingwithbacteria.wordpress.com/2012/05/02/five-tips-for-coming-up-with-a-winning-igem-project/

Five tips for coming up with a winning iGEM project

1. Start from a problem

2. Start from an advance or discovery

3. Find something cool, then add ‘Bio’ in front of it, or ‘coli’ to the end of it

4. Start as broad as you can

5. Browse the registry & past teams’ work

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Craig Venter

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JCVI-syn3.0 (Image: Tom Deerinck and Mark Ellisman of the National Center for Imaging and Microscopy Research at the University of California at San Diego)

Mycoplasma mycoides

473 genes

149 genes with unknown function

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Kopi luwak

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Kopi luwak

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Unique sugar profile of Cultured Coffee vs control (liquid and gas chromatography, HPAEC)

Kopi luwak

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Simpson’s Paradox

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1973 grad school admission UC Berkley

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1973 grad school admission UC Berkley

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Chuang, John S., Olivier Rivoire, and Stanislas Leibler. "Simpson's paradox in a synthetic microbial system." Science 323.5911 (2009): 272-275.

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Chuang, John S., Olivier Rivoire, and Stanislas Leibler. "Cooperation and Hamilton's rule in a simple synthetic microbial system." Molecular systems biology 6.1 (2010).

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Dimitriu, T., Lotton, C., Bénard-Capelle, J., Misevic, D., Brown, S.P., Lindner, A.B. and Taddei, F., 2014. Genetic information transfer promotes cooperation in bacteria. Proceedings of the National Academy of Sciences, 111(30), pp.11103-11108.

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