32011-015 R 4/13 (M) SURVIVING SEPSIS CAMPAIGN BUNDLES Initial Resuscitation Bundle To Be Completed in 3 hours: 1) Measure lactate level 2) Obtain cultures prior to administration of antibiotics 3) Administer broad spectrum antibiotics 4) Administer 30ml/kg crystalloid for hypotension or lactate greater than or equal to 4mmol/kg Septic Shock Bundle To be Completed Within 6 Hours: 1) Apply vasopressors (for hypotension that does not respond to initial fluid resuscitation) to maintain a mean arterial pressure (MAP) greater than or equal to 65mmHg 2) In the event of persistent arterial hypotension despite volume resuscitation (septic shock) or initial lactate greater than or equal to 4mmol/L a. Measure central venous pressure (CVP)* b. Measure central venous oxygen saturation (ScvO2)* 3) Remeasure lactate if initial lactate was elevated* *Targets for quantitative resuscitation included in the guidelines are CVP greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and normalization of lactate
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32011-015 R 4/13 (M) 32011-015 R 4/13 (M)32011-015 R 4/13 (M) 32011-015 R 4/13 (M)
32011-015 R 4/13 (M) 32011-015 R 4/13 (M)32011-015 R 4/13 (M) 32011-015 R 4/13 (M)
Surviving SepSiSCampaign BundleS
Initial Resuscitation BundleTo Be Completed in 3 hours:1) Measure lactate level2) Obtain cultures prior to administration of antibiotics3) Administer broad spectrum antibiotics4) Administer 30ml/kg crystalloid for hypotension or lactate greater
than or equal to 4mmol/kg
Septic Shock BundleTo be Completed Within 6 Hours:1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure (MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume resuscitation (septic shock) or initial lactate greater than or equal to 4mmol/L
a. Measure central venous pressure (CVP)* b. Measure central venous oxygen saturation (ScvO2)*3) Remeasure lactate if initial lactate was elevated*
*Targets for quantitative resuscitation included in the guidelines are CVP greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and normalization of lactate
Surviving SepSiSCampaign BundleS
Initial Resuscitation BundleTo Be Completed in 3 hours:1) Measure lactate level2) Obtain cultures prior to administration of antibiotics3) Administer broad spectrum antibiotics4) Administer 30ml/kg crystalloid for hypotension or lactate greater
than or equal to 4mmol/kg
Septic Shock BundleTo be Completed Within 6 Hours:1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure (MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume resuscitation (septic shock) or initial lactate greater than or equal to 4mmol/L
a. Measure central venous pressure (CVP)* b. Measure central venous oxygen saturation (ScvO2)*3) Remeasure lactate if initial lactate was elevated*
*Targets for quantitative resuscitation included in the guidelines are CVP greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and normalization of lactate
Surviving SepSiSCampaign BundleS
Initial Resuscitation BundleTo Be Completed in 3 hours:1) Measure lactate level2) Obtain cultures prior to administration of antibiotics3) Administer broad spectrum antibiotics4) Administer 30ml/kg crystalloid for hypotension or lactate greater
than or equal to 4mmol/kg
Septic Shock BundleTo be Completed Within 6 Hours:1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure (MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume resuscitation (septic shock) or initial lactate greater than or equal to 4mmol/L
a. Measure central venous pressure (CVP)* b. Measure central venous oxygen saturation (ScvO2)*3) Remeasure lactate if initial lactate was elevated*
*Targets for quantitative resuscitation included in the guidelines are CVP greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and normalization of lactate
Surviving SepSiSCampaign BundleS
Initial Resuscitation BundleTo Be Completed in 3 hours:1) Measure lactate level2) Obtain cultures prior to administration of antibiotics3) Administer broad spectrum antibiotics4) Administer 30ml/kg crystalloid for hypotension or lactate greater
than or equal to 4mmol/kg
Septic Shock BundleTo be Completed Within 6 Hours:1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure (MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume resuscitation (septic shock) or initial lactate greater than or equal to 4mmol/L
a. Measure central venous pressure (CVP)* b. Measure central venous oxygen saturation (ScvO2)*3) Remeasure lactate if initial lactate was elevated*
*Targets for quantitative resuscitation included in the guidelines are CVP greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and normalization of lactate
Surviving SepSiSCampaign BundleS
Initial Resuscitation BundleTo Be Completed in 3 hours:1) Measure lactate level2) Obtain cultures prior to administration of antibiotics3) Administer broad spectrum antibiotics4) Administer 30ml/kg crystalloid for hypotension or lactate greater
than or equal to 4mmol/kg
Septic Shock BundleTo be Completed Within 6 Hours:1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure (MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume resuscitation (septic shock) or initial lactate greater than or equal to 4mmol/L
a. Measure central venous pressure (CVP)* b. Measure central venous oxygen saturation (ScvO2)*3) Remeasure lactate if initial lactate was elevated*
*Targets for quantitative resuscitation included in the guidelines are CVP greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and normalization of lactate
Surviving SepSiSCampaign BundleS
Initial Resuscitation BundleTo Be Completed in 3 hours:1) Measure lactate level2) Obtain cultures prior to administration of antibiotics3) Administer broad spectrum antibiotics4) Administer 30ml/kg crystalloid for hypotension or lactate greater
than or equal to 4mmol/kg
Septic Shock BundleTo be Completed Within 6 Hours:1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure (MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume resuscitation (septic shock) or initial lactate greater than or equal to 4mmol/L
a. Measure central venous pressure (CVP)* b. Measure central venous oxygen saturation (ScvO2)*3) Remeasure lactate if initial lactate was elevated*
*Targets for quantitative resuscitation included in the guidelines are CVP greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and normalization of lactate
Surviving SepSiSCampaign BundleS
Initial Resuscitation BundleTo Be Completed in 3 hours:1) Measure lactate level2) Obtain cultures prior to administration of antibiotics3) Administer broad spectrum antibiotics4) Administer 30ml/kg crystalloid for hypotension or lactate greater
than or equal to 4mmol/kg
Septic Shock BundleTo be Completed Within 6 Hours:1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure (MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume resuscitation (septic shock) or initial lactate greater than or equal to 4mmol/L
a. Measure central venous pressure (CVP)* b. Measure central venous oxygen saturation (ScvO2)*3) Remeasure lactate if initial lactate was elevated*
*Targets for quantitative resuscitation included in the guidelines are CVP greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and normalization of lactate
Surviving SepSiSCampaign BundleS
Initial Resuscitation BundleTo Be Completed in 3 hours:1) Measure lactate level2) Obtain cultures prior to administration of antibiotics3) Administer broad spectrum antibiotics4) Administer 30ml/kg crystalloid for hypotension or lactate greater
than or equal to 4mmol/kg
Septic Shock BundleTo be Completed Within 6 Hours:1) Apply vasopressors (for hypotension that does not respond to
initial fluid resuscitation) to maintain a mean arterial pressure (MAP) greater than or equal to 65mmHg
2) In the event of persistent arterial hypotension despite volume resuscitation (septic shock) or initial lactate greater than or equal to 4mmol/L
a. Measure central venous pressure (CVP)* b. Measure central venous oxygen saturation (ScvO2)*3) Remeasure lactate if initial lactate was elevated*
*Targets for quantitative resuscitation included in the guidelines are CVP greater than or equal to 8mmHg, ScvO2 greater than or equal to 70% and normalization of lactate
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