B KRT7 APOC1 MSLN CLDN4 UBE2C UBD GDF15 MISP MMP7 EPCAM REG4 KRT17 KRT18 MMP11 MUC13 MYBL2 LGALS4 ETV4 COL1A1 MUC3A CTHRC1 HOXA10 HOXC10 CLDN1 CXCL1 TOP2A TPX2 SOX9 AGR2 EPHB2 CDKN2A PPP1R1B CLDN7 GRIN2D APOE BGN MKI67 MARCKSL1 SPP1 PKMYT1 FOXM1 CDC20 VIL1 HNF4A GPRC5A CLDN2 MMP1 CHI3L1 CRYAB ANGPTL1 PSD RBPMS2 SOSTDC1 C16orf89 TCEAL2 PRIMA1 MAMDC2 PLIN4 FXYD1 HBA2 CFD HBA1 PLN SST PI16 LMOD1 SFRP1 PGM5−AS1 HSPB8 PNCK SYNPO2 ADH1B PPP1R1APGM5 FHL1 ATP4A CKB CCL14 SYNM GIF HSPB6 HBB CNN1 MYOC ATP4B DPT ACTG2 MYH11 GKN2 C2orf40 MAL PGA5 GKN1 PGA4 PGA3 0 3 6 9 12 −4 −2 0 2 4 log2(Fold Change) −log10( p −value) DEGs of tumor versus paired normal samples in TCGA dataset A Normal Tumor −2 −1 0 1 2 3 D Surgical resected samples Targeted biopsies samples under magnifying endoscopy p = 3.1e-06 p = 0.001 0 5 10 Tumor Normal REG4 0.0 2.5 5.0 7.5 10.0 Tumor Normal CLDN7 p = 0.0045 0 5 10 15 Tumor Normal PGA3 p = 0.0037 0 5 10 15 Tumor Normal GKN1 Malignant epithelial cells Non-malignant epithelial cells Top 50 genes in tumor Top 50 genes in normal Scaled exp CG(97%) DGC(2%) IGC1(67%) IGC2(34%) IGC3(50%) IGC4(1%) IGC5(15%) MGC1(83%) MGC2(39%) MGC3(33%) NC1(98%) NC2(99%) C BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any reliance Supplemental material placed on this supplemental material which has been supplied by the author(s) Gut doi: 10.1136/gutjnl-2019-320368 –12. :1 70 2021; Gut , et al. Zhang M
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B
KRT7
APOC1
MSLNCLDN4
UBE2C
UBD
GDF15
MISPMMP7
EPCAM
REG4
KRT17KRT18
MMP11
MUC13
MYBL2
LGALS4
ETV4
COL1A1
MUC3A
CTHRC1HOXA10
HOXC10CLDN1
CXCL1
TOP2ATPX2
SOX9
AGR2
EPHB2
CDKN2A
PPP1R1BCLDN7
GRIN2D
APOE
BGN
MKI67MARCKSL1
SPP1
PKMYT1
FOXM1
CDC20
VIL1
HNF4AGPRC5ACLDN2
MMP1
CHI3L1
CRYABANGPTL1
PSD
RBPMS2
SOSTDC1
C16orf89
TCEAL2
PRIMA1
MAMDC2
PLIN4
FXYD1
HBA2
CFD
HBA1
PLNSST
PI16
LMOD1
SFRP1
PGM5−AS1
HSPB8 PNCKSYNPO2
ADH1B
PPP1R1APGM5FHL1
ATP4A
CKBCCL14
SYNMGIFHSPB6
HBB
CNN1
MYOC
ATP4B
DPT
ACTG2MYH11
GKN2
C2orf40
MAL
PGA5
GKN1PGA4
PGA3
0
3
6
9
12
−4 −2 0 2 4log2(Fold Change)
−log10(p
−valu
e)
DEGs of tumor versus paired normal samples in TCGA datasetA
NormalTumor
−2
−1
0
1
2
3
D Surgical resected samples
Targeted biopsies samples under magnifying endoscopy
p = 3.1e-06 p = 0.001
0
5
10
Tumor Normal
REG4
0.0
2.5
5.0
7.5
10.0
Tumor Normal
CLDN7
p = 0.0045
0
5
10
15
Tumor Normal
PGA3
p = 0.0037
0
5
10
15
Tumor Normal
GKN1
Malignant epithelial cells Non-malignant epithelial cells
To
p 5
0 g
en
es in
tu
mo
rTo
p 5
0 g
en
es in
no
rma
l
Sca
led
exp CG(97%) DGC(2%) IGC1(67%)
IGC2(34%)
IGC3(50%)IGC4(1%)
IGC5(15%)
MGC1(83%)
MGC2(39%)
MGC3(33%)
NC1(98%)
NC2(99%)
C
BMJ Publishing Group Limited (BMJ) disclaims all liability and responsibility arising from any relianceSupplemental material placed on this supplemental material which has been supplied by the author(s) Gut
doi: 10.1136/gutjnl-2019-320368–12.:1 70 2021;Gut, et al. Zhang M
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