Steril Rangkuman Formula

8/16/2019 Steril Rangkuman Formula

1/22

INFUS ANTIDOTUMA. Formula Rujukan (Martindale 28 hal 393)

Tiosulfat 30

Na !i"ar!onate 2

Tiosulfat #0

Na !i"ar!onate 0$%

Na nitrit 3 dala& larutan in'esi #0 &l

Meds"ae

Na tiosulfat #2$* + (ie$ *0&l)

B. Formula Jadi

NaNO2 3%

Na2S2O3 2,5%

Aqua PI ad 500 mL

,erhitun+an dan ,eni&!an+an

Akan diua! in"u# 500 ml #$anak 2 o!ol &'000 ml(

)olum$ !o!al * &) + n ( &'0% + -olum$ an diua!(

* &500 ml + 2( &&'0% + 2&500ml((

* ''00 ml

NaNO2 *3 gram

100ml + ''00mL * 33 ram

Na2S2O3 *2,5 gram

100ml + ''00mL * 2/,5 ram

P$ri!unan I#o!oni#

Na1l * &+ ( + ''','' mL

* 433 ram + 0,67&2/,5 ram + 0,3'( + ''',''mL

* &2/,/2 ,52 ( + ''',''

* 602/,'2 ml

% 8oni#i!a# *4027,182ml

1100ml + 0,9 % * 0,33 % &:i;o!oni#(

Na1l * 0,9% < 0,33% * 0,5/ %

*

0,57gram

100ml + ''00 ml * =,2/

P$nimanan di!ama 5% un!uk di#$ra; nori! >

NaNO2 * &33 + ''00ml?'000ml( 5% &33 + ''00ml?'000ml( * 3,''5

Na2SO3 * &2/,5 + ''00ml?'000ml( 5% &2/,5 + ''00ml?'000ml( * 3',/=

Na1l * &=,2/ + ''00ml?'000ml( 5% &=,2/ + ''00ml?'000ml( * /,26

Aqua P.i ad ''00ml

Nori! * 0,' % + ''00ml * ','

:2O2 * 0,' % @ ''00ml * ','

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INFUS D-.T/OSA (#) For&ula dasar (Martindale 28th ed *2)

$k#!ro#a 5%

Aqua ;i '00%

(2) For&ula ran"an+an1

'. o#i# $k#!ro#a &luko#a(un!uk in"u# I) adala 5% dan $r"un#i #$aai

#um$r kalori a!au karoidra! an di;$rlukan ol$ !uu, umumna un!uk

;a#i$n an m$nd$ri!a i;olik$mik. $milki $"$k #am;in ai!u, d$mam,

in"$k#i ;ada !$m;a! inj$k#i, !romo#i# -$na, !romo;l$i!# dan $k#!ra-a#a#i,

;o;o#;a!$mia ila diunakan ;ada janka Caak!u an lama.

Don!raindika#i d$nan ;$nd$ri!a dia$!$# m$li!u# dan in!ol$ran !$rada;

karoidra! un!uk ala#an a;a;un. P$rina!anna adala di$rikan kar$na da;a!m$n$akan i;okal$mia, i;oman$#ia, kondi#i Eon$#!i-$ dan $d$ma

;ulmonar.

2. Na1l diunakan #$aai ;$ni#o!oni# aar #$diaan in"u# #$!ara d$nan

!oni#i!a# Eairan !uu ai!u 0,9 %. o#i# Na1l an diunakan adala 0,' %,

do#i# !$r#$u! di;akai $rda#arkan ;$ri!unan !oni#i!a# an !$la dii!un.

Laru!an in"u# diua! i#o!oni# $r!ujuan un!uk m$nE$a iri!a#i ;ada ;$mulu

dara.

)olum$ in"u# diua! 500 mL kar$na umumna #$diaan in"u# dalam jumla

$#ar &250 mL, 500 mL dan '000 mL(. )olum$ !$r#$u! !$la di;$ri!unkan

a!a# da#ar k$u!uan ;a#i$n an m$nd$ri!a i;olik$mik

(3) For&ula 'adi1

$k#!ro#a 5%

Na!rium klorida 0,'%

Aqua #!$ril ;i ad 500 mL

,erhitun+an

iua! 2 o!ol in"u# 500 mL. 8o!al -olum$ '000 mL.

)olum$ in"u# '000 mL &'0 % + '000 mL( * ''00 mL.

P$ri!unan !oni#i!a#

Jumla luko#a dalam "ormula * 5 %, maka !oni#i!a# an di;$rol$* 5 % + 0,'= * 0, % Na1l i;o!oni#

Jadi, ;$r#$n Na1l dalam "ormula aar i#o!oni#

* 0,9 % < &5 % + 0,'=( * 0,' %

Na1l * 0,' % + ''00 mL

* ',' &5 % + ',' (

* ','55

$k#!ro#a &luko#a( * 5 % + ''00 mL

* 55 &5 % + 55 (* 5/,/5

1aro ad#or$n * 0,' % + ''00 mL * ','

:2O2 * 0,' % + ''00 mL* ',' mLun!uk ''00 mL aqua ;.i.

Aqua #!$ril ;i ad ''00 mL

2


3/22

INFUS O4- /IN5-/ For&ula ru'uan

FI 6 hal #722

Na!rium klorida P 9,0 ram

Dalium klorida P 0,62 ram

Dal#ium klorida P 0,26 ram

an$#ium klorida P 0,2 ram

Na!rium ikarona! P 0,5 ram

$k#!ro#a P 0,5 ram

Air an aru di d$#!ila#i dari lau kaEa k$ra# ina '000 ml

Martindale 28 hal %38Sodium Elorid$ 900 m

Po!!a#ium Elorid$ 62 m

Androu# EalEium Elorid$ 26 m

Andro# d$+!ro#$ '00 m

Sodium ikarona!$ 50 m

a!$r !o '00

For&ula an+ aan di!uat

Na!rium klorida 6,5 ram

Dalium klorida 0,2' ramDal#ium klorida 0,'2 ram

an$#ium klorida 0,' ram

Na!rium ikarona! 0,25 ram

$k#!ro#a 0,25 ram

Aqua ;.i ad 500 ml

,erhitun+an Isotonis

D$#$!araan $qui-al$n $l$k!roli! &ar!indal$ 2 al. =60, S;roCl# (

' Na1l G '/,' mq Na ' * '

' D1l G '3,6 mq D 2 * 0,/=

' 1a1l2 G '3,= mq 1a2 3 * 0,5'' 1l2 G9. mq

2 6 * 0,6

' Na:1O3 G ''.9 mq Na2 5 * 0,=5

$+#!ro#a = * 0,'=

P$ri!unan mq adala #$aai $riku! >

Na1L * '/,' mq?' + 6,5 * /=,95 mq?500 mL * '53,9 mq?L

D1L * '3,6 mq?' + 0,2' * 2,'6mq?500 mL * 5,=2 mq?L

1a1l2 * '3,= mq? ' + 0,'2 * ',=32 mq?500 l * 3,2=6 mq?L

1l2 * 9, mq? ' + 0,' * 0,9 mq?500 l * ',9= mq?L

Na:1O3 * '',9 mq? ' + 0,25 * 2,9/5 mq?500 l * 5,95 mq?L

) * 4&' + '( &2 + 2( &3 + 3( &6 + 6( &5 @ 5( &= @ =(7 + ''',''

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mL

* 4&6.5 + '( &0.2' + 0,/=( &0,'2 + 0.5'( &0.' + 0.6( &0,25 + 0,=5( &0,25 +

0,'=(7 + ''','' mL

* 46.5 0.'59= 0.0='2 0.06 0,'=25 0,06(7 + ''',''

* 6,9/'3 + ''','' mL

* 552,3/mL% 8oni#i!a# * 5 52,3/ ml + 0,9% * 0,9963% &:IPR8ONIS(

500 ml

Laju 8$!$# ;$rm$ni! > 0,9% + 60 !$!$# * 3=,20=6 !$!$#G3= !$!$#

0,9963 %

I#o!oni# * P$nimanan un!ik 2 o!ol in"u# 500mL

) * 4&2 + 500mL( '0%&2 + 500mL(7

* ''00 mL

,eni&!an+an !ahan

P$nimanan un!uk 2 o!ol in"u# ma#in &0,2' + ''00 ? '000ml( * 0,23'

1a1l2 >&0,'2 + ''00 ? '000ml( * 0,'32

1l2 >&0,' + ''00 ? '000ml( * 0,''

Na:1O3 > &0,25 + ''00 ? '000ml( * 0,2/5

$k#!ro#$ > &0,25 + ''00 ? '000ml( * 0,2/5

Air ;i ad 550 ml

,eni&!an+an dita&!ah * untu disera norit

Na1l > 6,95ram &5% + 6,95ram( * 5,'9/5 ram

D1l > 0,23' ram &5% + 0,23' ram( * 0,2625 ram

1a1l2 > 0,'32 ram &5% + 0,'32 ram( * 0,'3= ram

1l2 > 0,'' ram &5% + 0,'' ram( * 0,''55 ram

Na:1O3 > 0,2/5 ram &5% + 0,2/5 ram(* 0,2 ram

$k#!ro#a > 0,2/5 ram &5% + 0,2/5 ram(* 0,2 ram

Nori! > 0,' ram?'00 ml + 550 ml * 0,5500 ram

:2O2 > 0,' ram?'00 ml + 550 ml * 0,5500 ram

Jadi, un!uk ;$nimanan dua o!ol in"u#

Na1l > 5,'9/5 ram + 2 * '0,395 ramD1l > 0,2625 ram + 2 * 0,652 ram

1a1l2 > 0,'3= ram + 2 * 0,2//2 ram

1l2 > 0,''55 ram + 2 * 0,23'0 ram

Na:1O3 > 0,2 ram + 2 * 0,5//= ram

$k#!ro#a > 0,2 ram + 2 * 0,5//= ram

Nori! > 0,5500 ram + 2 * ','00 ram

:2O2 > 0,5500 ram + 2 * ','00 ram

4


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INFUS /IN5-/ DAN INFUS I,O4A-MIA$ I,ONAT/-MIAFor&ula dasar

For&ula !erdasaran US, 37 hal :*8:

Na!rium Dlorida .=

Dalium Dlorida 0.3

Dal#ium Dlorida 0.33

Air ;ro inj$k#i ad '000 mL

For&ula !erdasaran Martindale 28 hal %38

Na!rium Dlorida =0 m

Dalium Dlorida 30 m

Dal#ium Dlorida &diidra!( 33 m

Air ;ro inj$k#i ad '00 ml

For&ula !erdasaran DI 88 hal #:77

N '6/,5 mq

D 6 mq

1a2 6,5 mq

Air ;ro inj$k#i ad '000 ml

For&ula !erdasaran FI 6 hal ##0:8ia; '00 ml m$nandun

Na1l 20,0 m H 900,0 m

D1l 2,5 m H 3',5 m

1a1l2.2:2O 30,0 m H 3=, 0 m

1l2 523,0 m H 50,0 m

5


6/22

AM,U 4ININFORLA RJDAN

ar!indal$ 2! al 60=

uinin$ idroklorid$ '05 m un!uk ;$m$rian in!ramu#kular

uinin$ diidroElorid$ 300

Dinin idroklorida '05 m

Aqua #!$ril ;ro inj$k#i ad ' ml

,erhitun+an

Am;ul

)* && n 2( - &2 + 3(( ml

* && '0 2 ( &''0%(( &2 + 3(( ml * '9,2 ml G '9,5 ml

Duinin idroklorida * '05 + '9,5 ml * 206/,5 m * 2,06/5

Si#a aqua #!$ril ;ro inj$k#i * '9,5 ml


7/22

Pro;il$n likol 60%

Alkool '0 %

Sodium dro+id$ !o adju#! ;:

a!$r "or inj$E!ion q#

! (Martindale edisi 28 hal #2::$ Tahun #982

P$n!oin Sodium 6,/5 < 5,25 %Pro;il$n likol 60%

Alkool '0 %

a!$r "or inj$E!ion

2 For&ula ;adi

8ia; am;ul m$nandun>

P$n!oin Sodium 5 %

Pro;il$n likol 60%

Alkool '0 %

Aqua #!$ril ;ro inj$E!ionad 2 ml

,roilen +liol diunakan #$aai ;$laru! Eam;ur un!uk m$ninka!kank$laru!an dan k$#!ailan "$ni!oin, ai!u ;ro;il$n likol 60% dan alkool '0% kar$na

F$ni!oin #odium laru! dalam air, akan !$!a;i #$Eara $r!aa; m$na#or#i

karondiok#ida dan akan m$nalami idroli#a ;ar#ial m$njadi "$ni!oin. :al ini

di!unjukkan ol$ laru!an $nE$rna an m$njadi k$ru (DI 88 hal 1119)

-tanol diunakan #$aai ;$laru! Eam;ur un!uk m$ninka!kan k$laru!an dan

k$#!ailan "$ni!oin, ai!u ;ro;il$n likol 60% dan alkool '0% kar$na F$ni!oin

#odium laru! dalam air, akan !$!a;i #$Eara $r!aa; m$na#or#i karondiok#ida

dan akan m$nalami idroli#a ;ar#ial m$njadi "$ni!oin. :al ini di!unjukkan ol$

laru!an $nE$rna an m$njadi k$ru (DI 88 hal 1119)

Natriu& hidrosida di!amakan un!uk m$nEa;ai ;: '2, kar$na "$ni!oin

akan m$n$nda; ;ada ;: diaCa '',5. (DI 88 hal 1119)

iua! '5 am;ul 2 ml

) * K& n 2 ( - & 2 + 3 ( ml

* K& '5 2 ( &2 0,'5( & 2 + 3 ( ml

* 62,55 ml M 63 ml

P$ri!unan un!uk ;$nimanan >

B FNI8OIN * 252,2/

B FNI8OIN Na * 2/6,25

P$n!oin Na * 2/6,25?252,2/ + 5 % * 0,0563 ?ml * 0,0563 ?ml + 3' mL * ',=33

Pro;il$nlikol * 60% + 3' ml * '2,6 mLAlkool * '0% + 3' ml * 3,'mL

NaO: ' N q.#

Aqua S!$ril Pro Inj$E!ion ad 63 mL

AM,U F-NITOIN

For&ula /u'uan (and!oo of har&a"euti"al &anufa"turin+ for&ulations$ 2nd edition


8/22

Poli-inil ;irolidon '00m

Sodium :dro+id$ 'N 'mL

P$n!oin Sodium 50m

Sodium :dro+id$ "or ;: Adju#!m$n! q#

a!$r "or Inj$E!ion q#

Ni!ro$n a# q#(In'e"ta!le Dru+ edisi #: hal #:30$ Tahun 2007)

8ia; ml am;ul m$nandun>

P$n!oin Sodium 50m

Pro;il$n likol 60%

Alkool '0 %


a!$r "or inj$E!ion q#

A For&ula ;adi

(In'e"ta!le Dru+ edisi #: hal #:30$ Tahun 2007)

8ia; am;ul m$nandun>P$n!oin Sodium '00 m

Pro;il$n likol 60%

Alkool '0 %


Aqua #!$ril ;ro inj$E!ion ad 2 ml

,erhitun+an

iua! '0 am;ul 2 ml

) * K& n 2 ( - & 2 + 3 ( ml* K& '0 2 ( &2 0,'5( & 2 + 3 ( ml

* 3', ml M 32 ml

P$ri!unan un!uk ;$nimanan >

B FNI8OIN * 252,2/

B FNI8OIN Na * 2/6,25

P$n!oin Na * 2/6,25?252,2/ + '00 m * '0,/'29 m

* '0,/'29 m?2ml + 32 mL * '/39,606m * ',/6 ram

Pro;il$nlikol * 60% + 32 ml * '2, mL

Alkool * '0% + 32 ml * 3,2 mL

NaO: ' N q.#Aqua S!$ril Pro Inj$E!ion ad 32 mL

AM,U ,/OM-TA=IN

'. Formula a#ar

Formula $rda#arkan In'e"ta!le #:th edition hal #:#0

8ia; ml m$nandun

8


9/22

Prom$!ain :1l 25 m

i#odium $d$!a! 0,' m

Dal#ium klorida 0,06 m

Sodium m$!ai#ul"i! 0,25 m

F$nol 5 m

A#am a#$!a! q#Sodium a#$!a! q#

Air un!uk inj$k#i q#

Formula $rda#arkan and!oo of ,har&a"euti"al Manufa"turin+

For&ulation1 Sterile ,rodu"ts hal 3%8

Prom$!ain :1l 25 m

Sodium $!ai#ul"i! 0,25 m

1airan F$nol 5 m

A#am A#$!a! q#

Sodium A#$!a! q#

Air un!uk inj$k#i q#a# ni!ro$n q#

2. Formula Jadi

8ia; mL am;ul in!ra-$na m$nandun>

Prom$!ain :1l 25 m

Sodium $!ai#ul"i! 0,25 m

Air un!uk inj$k#i ad ' mL

AM,U DIF-NID/AMIN

'. Formula Rujukan

•

SP NF d 3= :al 32/=alam ' mL m$nandun >

9


10/22

i"$nidramin :1l 50m

Aqua Pro Inj$k#i

• Inj$E!al$ ru alaman 535

alam ' mL m$nnandun >

i"$nidramin :1l 50 m

Aqua Pro Inj$k#I2. Formula R$nEana

8ia; ml am;ul I. m$nandun>

i"$nidramin :1l 50 m

Aqua #!$ril ;.i ad. ' ml

P$ri!unan -olum$

) * &&n2(- &2+3((

D$!$ranan n * jumla am;ul

- * -olum$ am;ul k$l$ian -olum$

2+3 ml * un!uk ;$mila#an

$mua! '0 am;ul >

) * K&'02( ',' &2+3(

* '9,2 ml M '9,5 ml

< i"$nidramin :1l * 50 m?ml + 20 ml * '000 m

< Aqua #!$ril ;ro inj$k#i ad '9,5 ml

AM,U AMONIUM 4O/IDA

For&ula ru'uan 1

a A&&oniu& "hloride in'e"tion (2$#:) &S!$ril$ o#a$ Form#, 8urEo al '//(8ia; ' Li!$r m$nandun >

10


11/22

600 mq?L N:6 dan 1l<

! A&&oniu& "hloride in'e"tion &ar!indal$ 2 al =/(

Infus intra

N:61l 2=,/5%

Aqua ;.i ad ' mL

• iua! '2 am;ul d$nan -olum$ ' mL

• D$l$ian -olum$ &Farmako;$ Indon$#ia I) . '066( * 0,'0 ml

)olum$ am;ul > ' ml 0,'0 ml * ','0 ml

)olum$ inj$k#i * 4&n2( - &2+3(7 ml

* 4&'02( ','0 &2+3(7

* '9,2 * 20 mL

N:61l * 2=,/5% + 20 mL * 5,35

D$! >

n * jumla am;ul

2 * Eadanan

- * -olum$ am;ul k$l$ian -olum$

2 + 3 * un!uk ;$mila#an

6IA ID/O4O/TISONFORLA RJDAN

>erdasaran and!oo On In'e"ta!le Dru+ -disi ## hala&an %97

:droEor!i#on$ Na!rium Po#;a! !$r#$dia dalam 2 ml -ial do#i# !unal, !ia; ml laru!anm$nandun >

11


12/22

:droEor!i#on Na!rium ;o#;a! 50 m

1r$a!inin$ m

Sodium Ei!ra!$ '0 m

Sodium i#ul"i!$ 3.2 m

$!l;ara$n '.5 m

Pro;l;ara$n 0.2 mSodium :droid$ !o adju#! ;:

a!$r "or inj$E!ion q# ' ml

DI 20#0 alala&an 3082

:idrokor!i#on Na "o#"a! 50 m?ml

FORLA JAI

Formula an di;ili $rda#arkan li!$ra!ur I 20'0 alaman 302, ai!u >

8ia; ml -ial m$nandun

:idrokor!i#on #odium "o#"a! 50 m?ml

B$nalkonium klorida 0.0'%

Na!rium :idrok#ida q#Aqua ak!$rio#!a!ik ;ro inj$k#i ad 5 ml

A. PR:I8NAN

B$rda#arkan li!$ra!ur FI I) al.'066 !$n!an ;$n$!a;an -olum$ inj$k#i dalam Cada >

) * 5ml 0,3

) * 5,3 ml

iua! 5 -ial 5 ml

)olum$ !o!al * &5 + 5,3 ml( 30 % &5 + 5,3 ml(

* 2=,5 ml /,95 ml

* 36,65 ml G 35 ml

:idrokor!i#on Na ;o#;a! * 50 m?ml + 35 ml

* ',/5

B$nalkonium klorida* 0,0' % + 35 ml

* 3,5 m ;$n$nE$ran

P$n$nE$ran >3,5mg

10mg ×5ml=1,75ml 35tetes

Aqua ;ro inj$k#i ad 35 ml

6IA /I>OFA6INa For&ula Dasar &ar!indal$ $di#i 2, al. '=62(

Rio"la-in Sodium Po#;a!$ =60 m1i!riE aEid monodra!$ =0 m

12


13/22

Sodium Elorid$ 50 m

a!$r "or inj$E!ion ad '00 ml

P$nlm$rEuriE ni!ra!$ 0,00'%

! For&ula ;adi

Rio"la-in 30m?mlB$nalkonium klorida 0.0'%

Niko!inamid 300m?ml

Aqua ak!$rio#!a!ik ;ro inj$k#i ad '0ml

P$ri!unan

Rumu# > 4& n + -( & '0 % < 30% + -(7

n * Jumla -ial an akan diua!

- * )olum$ inj$k#i !ia; )ial &ml(

)olum$ !o!al 5 -ial * 4& n + - ( & 20 % + - (7 ml

* 4&5 + &'0 ml 0.5 ml(( &20% + 5&'0 ml 0.5

* =3 ml

o#i# Rio"la-in * 30 m?ml

8o!al Rio"la-in * 30 m?ml + =3ml

* '90 m

B$nalkonium klorida* 0,0'% + =3 ml

* =.3 ml

P$n$nE$ran $nalkonium klorida

•

B$nalkonium klorida * 20 m• Aqua ak!$rio#!a!ik ;ro inj$k#i * 5 ml

aka, $nalkonium klorida an diamil * =,3 m?20m + 5 ml

* '.5/5 ml

* ' ml '2 !$!$#

Laru!an j$nu niko!inamid

• Niko!inamid * =3 ml + 300 m?ml * '900 m

• Aqua ak!$rio#!a!ik ;ro inj$k#i * q#

6IA S-FOTA4SIM

Formula Rujukan&:andook o" Inj$E!al$ dru# '6! $di!ion al 29= (

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14/22

R$kom$nda#i B$n!uk R$kon#!i!u#i S$"o!ak#im Na!rium

Ru!$ ;$m$rian > In!ra-$na

S$"o!ak#im Sodium 500m

Ad '0ml aqua ;ro

Aqua ak!$rio#!a!ik ;ro inj$k#i >B$nalkonium klorida 0,0'%

Aqua ;ro inj$k#i '0 mL

P$ri!unan

) * -olum$ !ia; -ial k$l$ian -olum$ &FI ) al. '5/0(

) * '0 mL 0,5 mL

) * '0,5 mL

iua! 5 -ial dil$ikan 2 * / -ial

)olum$ !o!al * &/ + '0,5mL( 430% + &/ + '0,5mL(7

* /3,5 mL &30% + /3,5mL(

* /3,5 mL 22,05 mL* 95, 55 mL * 9= mL

P$nimanan

• Qa! ak!i" >

S!r$;!mi#in Sul"a! *

Boo! ;$r -ial >

'0ml 2 ram

'0,5 ml

*10,5

10 x2=2,1g

2'00 m + / * '6/00 m * '6 ,/ ram.• Qa! !amaan >

B$nalkonium klorida * 0,0'% + 9= mL * 9,= m.

P$n$nE$ran $nalkonium klorida >

'0 m $nalkonium klorida di!ama aqua ;.i ad '0 mL.

B$nalkonium klorida * 9,=m + '0 mL * 9,= mL.

'0m

Aqua ;ro inj$k#i ad 9= mL.

6IA -MOSTATI4 For&ula /u'uan 1

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15/22

In'e"ta!le ed #0th hal #3:7

)i!amin D 2 a!au '0 m?mL

Polm$!l$n Fa!! AEid /0 m

$+!ro#$ 3/,5 m

B$nl AlEool 0,9%

Aqua "or Inj$k#i q#.

For&ulariu& Nasional edisi 2 hal #83

)i!amin D 2 m

Ol$um ;ro inj$k#i ad ' mL

For&ula /en"ana 1

8ia; 5 mL -ial inj$k#i in!ramu#kular m$nandun>

)i!amin D 5 m?mL

1loroEr$#ol 0,'%

Ol$um #$#ami ;ro inj$k#i ad 5 mL

)olum$ laru!an an akan diua!

)olum$ !o!al * &n + - ( &30% & n + - ((

* &5 + 5,5( &30% &5 + 5,5((

* 35,/5 mL

)i!amin D > 5 m?mL + 35,/5 mL * 0,'//5 * '/,/5 m

1loroEr$#ol > 0,'% + 35,/5 mL * 0,035/5 * 35,/5 m

Ol$um #$#ami 35,/5 mL * 3= mL

6IA ,A,A6-/IN

15


16/22

Formula ar!indal$ $di#i 3= alaman 2'9', ar!indal$ $di#i 29 al '59, :andook on

Inj$E!al$ dru# '6! $di!ion alaman '290

Pa;a-$rini :droElodirum 0 m

B$nalkonium Dlorida 0.0'%Aqua ;ro Inj$k#i ina 5ml

,erhitun+an

Rumu# * 4&n.-( &30%.-(7ml

D$!$ranan >

n * jumla -ial an akan diua!

- * -ol. Inj$k#i !ia; -ial &ml(

P$ri!unan -olum$ inj$k#i -ial * -olum$ &'0 < 30%(

)olum$ !o!al 5 -ial * 4&n.-( &30%.-(7ml

* 4&5.-( &30%.-(7ml* 4&5.5,3 &30%.5,37ml

* 2,09 ml G 30 ml

8o!al Pa;a-$rin :1l * 30?5+ 0 m * 60 m

* 0,6

8o!al B$nalkonium Dlorida * 0,0'% + 30 ml

* 0,003 * 3 m &P$n$nE$ran(

P$ri!unan ;$n$nE$ran>

'. B$nalkonium Dlorida di!iman '0 m

2. B$nalkonium dilaru!kan dalam 5 ml aqua ;.i.

3. Laru!an $nalkonium klorida diamil>

3m?'0m + 5 ml * ',5 ml

Si#a aqua ;i * 30 ml H&0,6 ',5 ml(

* 2,02 ml

6IA ANTI AN-MIA

# For&ula Dasar

& :andook o" Inj$E!al$ ru# di#i II al 3='ru In"orma!ion A:FS al 2'0=(

8ia; mL m$nandun >

1anoEoalamin '000 B$nalkonium klorida 0,0' %

16


17/22

Aqua ;ro inj$E!io ad ' ml

/an"an+an For&ula

8ia; mL m$nandun >

Sianokoalamin ' m

B$nalkonium klorida 0,0' %

Aqua ;ro inj$k#i ad ' ml

# For&ula ;adi

8ia; 5 mL m$nandun >

Sianokoalamin 5 m

B$nalkonium klorida 0,0' %

Aqua ;ro inj$k#I ad 5 ml

,erhitun+an

Rumu# * 4&n + -( &20 % + -(7 ml


- * -olum$ inj$k#i !ia; -ial &ml()olum$ !o!al 5 -ial * 4&n + -( &20 % + Kn + -(7 ml

* 4&5 + 5,3 ml( &20 % + 5 + 5,3(7 ml

* 3', ml M 32ml

8o!al )i!amin B'2 * 3 ', ml + 5 m

5 ml

* 3', m

Don-$r#i d$nan LAB '0 m?ml

* 3', m + ' ml

'0 m

* 3,' ml M 3,2ml

8o!al B$nalkonium klorida

* 0,0' % + 3', ml * 3, ' + '0

ia$;am 5 m

Pro;il$n likol 60 %

!anol '0 %

B$nil alkool ',5%

Sodium $noa! dan A#am B$noa! 5,0%

17


18/22

Aqua ;.i ad '0 mL

For&ula ;adi

8ia; '0 mL inj$k#i m$nandun>

ia$;am 5 m

Pro;il$n likol 60 %

!anol '0 %B$nil alkool ',5%

Sodium $noa! 5,0 %

Aqua ;.i ad '0 mL

,erhitun+an dan ,eni&!an+an

P$ri!unan

B$rda#arkan FI I) al. '5/0 !$n!an ;$n$!a;an -olum$ inj$k#i dalam Cada(

) * '0 mL 0,5 mL

* '0,5 mL

Rumu# >

) * 4&n + -( &30% + n + -( mlimana > - * -olum$ inj$k#i !ia; -ial &ml(


)olum$ !o!al !ia; 5 -ial * 4&n + -( &30% + n + -( ml

* 4& 5 + '0,5 mL ( &30% + 5 + '0,5(7 mL

* =,25 ml G =9 mL

ia$;am * 5 m?mL + =9 mL * 365 m

Pro;il$n likol * 60 % + =9 mL * 2/,= * 2/.=00 m

!anol * '0 % + =9 mL * =,9 * =.900 m

B$nil alkool * ',5 % + =9 mL * ',035 * '.035 m

Sodium $noa! * 5,0 % + =9 mL * 3,650 * 3.650 m

Aqua ;.i ad =9 mL

T-T-S MATA AT/O,IN SUFATa For&ula Dasar

ar!indal$ 2 al 292 & APF ( >

A!ro;in #ul"a! ' ,

Na1l /00 m,

Laru!an B$nalkonium 0,02 ml,

i#odium $d$!a! 50 m,

Air un!uk inj$k#i ad '00 mlI :al '5==

18


19/22

n!uk midria!ik dan #iklo;l$ia, un!uk d$Ca#a, ' !$!$# laru!an '% an

di!$!$#kan ;ada ma!a.

! /an"an+an For&ula

A!ro;in Sul"a! '%

Na!rium Dlorida 0,/%B$nalkonium Dlorida 0,02 %

ina!rium d$!a!$ 0,05 %

Air un!uk inj$k#i ad '0 ml

,-/ITUN5AN

" ,erhitun+an >ahan

iua! 2 o!ol oa! !$!$# ma!a '0ml

)olum$ !o!al an diua! * &2 + '0( ml 430% + &2 + '0(7 ml

* 20 ml = ml

* 2= ml A!ro;in Sul"a! * ' % + 2= ml * 0,2=

Na!rium Dlorida * 0,/% + 2= ml * 0,'2

B$nalkonium Dlorida * 0,02% + 2= ml * 0,0052

P$n$nE$ran B$nalkonium klorida >

B$nalkonium klorida '0 m

Aqua ;.i 5 ml

B$nalkonium klorida an diamil * &5,2 m?'0m( + 5 ml

* 2,= ml

ina!rium d$!a!$ * 0,05% + 2= ml * 0,0'3

T-T-S MATA OMAT/O,IN >/ I FO/MUA

(#) For&ula dasar

For&ula A"uan Tetes Mata o&atroin >r (Martindale 28 hal 302)

:oma!ro;in :idroromid$ 2%

B$nalkonium klorida 0,0'%

Aqua ;i q#

(2) For&ula ;adi

:oma!ro;in :idroromid$ 2%

19


20/22

B$nalkonium klorida 0,0'%

Na1l q#

Aqua ;i q#

ada !$!$# ma!a '0 ml.

II ,-M>UATAN(#) ,erhitun+an

)olum$ ' o!ol * '0 mL

iua! 2 o!ol * 2 + '0 mL * 20 mL

)olum$ !o!al * &nT-( 4&'0


21/22

B$nalkonium klorida 0,06 m

:droEloriE aEid 5 N q#

Sodium dro+oid$ ' N q#

a!$r ;uri"i$d q#

(A&eri"an osital For&ular Ser


22/22

2. ar!indal$ $d. 2 al. 3/=

Poli-inil alkool ',6 %

Na1l 0,9 % q.#

8iom$r#al 0,00' %

! For&ula ;adi

Poli-inil alkool ',6 %B$nalkonium klorida 0,0' %

Na1l 0,9=' %

Aqua ak!$rio#!a!ik ad '0 ml

Tonisitas

Na1l Poli-inil alkool *17.

L

M =17.

1,9

20000=1,615 .10

4&' + '0 ml( &'0 % + '0 ml + 2(7 * 22 ml

'. Poli-inil alkool * ',6 % + 22 ml * 0,30

2. B$nalkonium klorida * 0,0' % + 22 ml * 0,0022

3. Na1l * 0,9=' % + 22 ml * 0,'9/'

P$n$E$ran B$nalkonium klorida *2,2

10ml x10ml * 2,2 ml

6. Aqua ak!$rio#!a!ik * 22 ml

22

Steril Rangkuman Formula

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