Copyright © 2017 Abcam, All rights reserved. Stem cell lineage and identity Vascular cells Hematopoiesis – CD34 – c-Kit – Sca1 – RUNX1 Heman- gioblast – VEGFR2 – GATA2 – VE-Cadherin – Tie2 Mesoderm – BMP4 – CD31 – T-Brachyury – LEF1 Trophectoderm • CDX2 • EOMES Trophectoderm Inner cell mass – AP – CD9 – GCTM2 – NANOG – OCT4 – SOX2 – SSEA3 – SSEA4 – Tra-1-60 – Tra-1-81 Gastrula Epiblast Late blastocyst Blastocyst Zygote Endoderm – FOXA2 – GATA4 – GATA6 – HNF4a – SOX17 Ectoderm – GFAP – Islet1 – Neurofilament – Olig2 Primordial germ cells – DDX4 – IFITM1 – IFITM2 – SYCP3 Mesenchyme – CD105 – CD73 – CD90 Muscle – ABCG2 – MyoD – Myf5 – Pax7 Skin and hair – CD34 – Integrin β-1 – Keratin 15 Nervous system – Nestin – Noggin – Pax6 – Sox2 Mammary gland – Integrin β-1/ CD29 – CD24 – CD49f Male germ cells – Proacrosin – Tesmin – Piwil2 Female germ cells – PLAP – STAT3 – GDF9 Teratome Heart – Cripto1 – Islet1 – MESP – VEGFR2 Intestine – Musashi 1 – Wnt/ Notch/ BMP pathway Crypt stem cells Oval cells Lung stem cells Hematopoietic stem cells Mesenchymal stromal cells Satellite stem cells Neural stem cells Bulge stem cells Mammary gland stem cells Spermatogonial stem cells Cardiac progenitors Pancreas-derived multipotent precursors Pancreas – CK19 – Insulin – PDX1 Liver – a-fetoprotein – Albumin – Integrin β-1 Lungs – β-Catenin – LEF1 – Sca1 – Hes1 www.abcam.com
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Copyright © 2017 Abcam, All rights reserved.
Stem cell lineage and identity
Vascular cells
Hematopoiesis– CD34 – c-Kit – Sca1 – RUNX1
Heman-gioblast– VEGFR2 – GATA2– VE-Cadherin – Tie2
Mesoderm– BMP4 – CD31– T-Brachyury – LEF1
Trophectoderm• CDX2• EOMES
Trophectoderm
Inner cell mass– AP– CD9– GCTM2– NANOG– OCT4– SOX2– SSEA3– SSEA4– Tra-1-60– Tra-1-81
Gastrula
Epiblast
Late blastocyst
Blastocyst
Zygote
Endoderm– FOXA2 – GATA4 – GATA6 – HNF4a – SOX17
Ectoderm– GFAP – Islet1 – Neurofilament – Olig2
Primordialgerm cells– DDX4 – IFITM1 – IFITM2 – SYCP3
Mesenchyme– CD105 – CD73 – CD90
Muscle– ABCG2 – MyoD – Myf5 – Pax7
Skin and hair– CD34 – Integrin β-1 – Keratin 15
Nervoussystem– Nestin – Noggin– Pax6 – Sox2
Mammary gland– Integrin β-1/ CD29– CD24 – CD49f
Male germ cells– Proacrosin– Tesmin– Piwil2
Female germ cells – PLAP – STAT3 – GDF9
Teratome
Heart– Cripto1 – Islet1 – MESP – VEGFR2
Intestine– Musashi 1– Wnt/ Notch/ BMP pathway
Cryptstem cells
Oval cells Lungstem cells
Hematopoieticstem cells
Mesenchymalstromal cells
Satellitestem cells
Neuralstem cells
Bulgestem cells
Mammary glandstem cells
Spermatogonialstem cells
Cardiacprogenitors
Pancreas-derivedmultipotentprecursors
Pancreas– CK19– Insulin– PDX1
Liver– a-fetoprotein– Albumin– Integrin β-1
Lungs– β-Catenin– LEF1– Sca1– Hes1
www.abcam.com
Copyright © 2017 Abcam, All rights reserved.
Stem cell lineage and identity
Vascular cells
Hematopoiesis– CD34 – c-Kit – Sca1 – RUNX1
Heman-gioblast– VEGFR2 – GATA2– VE-Cadherin – Tie2
Mesoderm– BMP4 – CD31– T-Brachyury – LEF1
Trophectoderm• CDX2• EOMES
Trophectoderm
Inner cell mass– AP– CD9– GCTM2– NANOG– OCT4– SOX2– SSEA3– SSEA4– Tra-1-60– Tra-1-81
Gastrula
Epiblast
Late blastocyst
Blastocyst
Zygote
Endoderm– FOXA2 – GATA4 – GATA6 – HNF4a – SOX17
Ectoderm– GFAP – Islet1 – Neurofilament – Olig2
Primordialgerm cells– DDX4 – IFITM1 – IFITM2 – SYCP3
Mesenchyme– CD105 – CD73 – CD90
Muscle– ABCG2 – MyoD – Myf5 – Pax7
Skin and hair– CD34 – Integrin β-1 – Keratin 15
Nervoussystem– Nestin – Noggin– Pax6 – Sox2
Mammary gland– Integrin β-1/ CD29– CD24 – CD49f
Male germ cells– Proacrosin– Tesmin– Piwil2
Female germ cells – PLAP – STAT3 – GDF9
Teratome
Heart– Cripto1 – Islet1 – MESP – VEGFR2
Intestine– Musashi 1– Wnt/ Notch/ BMP pathway
Cryptstem cells
Oval cells Lungstem cells
Hematopoieticstem cells
Mesenchymalstromal cells
Satellitestem cells
Neuralstem cells
Bulgestem cells
Mammary glandstem cells
Spermatogonialstem cells
Cardiacprogenitors
Pancreas-derivedmultipotentprecursors
Pancreas– CK19– Insulin– PDX1
Liver– a-fetoprotein– Albumin– Integrin β-1
Lungs– β-Catenin– LEF1– Sca1– Hes1
www.abcam.com
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